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Gene: ENY2 |
Gene summary for ENY2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ENY2 | Gene ID | 56943 |
Gene name | ENY2 transcription and export complex 2 subunit | |
Gene Alias | DC6 | |
Cytomap | 8q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | Q9NPA8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56943 | ENY2 | P31T-E | Human | Esophagus | ESCC | 8.27e-117 | 2.46e+00 | 0.1251 |
56943 | ENY2 | P32T-E | Human | Esophagus | ESCC | 7.65e-86 | 1.89e+00 | 0.1666 |
56943 | ENY2 | P36T-E | Human | Esophagus | ESCC | 1.82e-46 | 1.64e+00 | 0.1187 |
56943 | ENY2 | P37T-E | Human | Esophagus | ESCC | 1.27e-63 | 1.50e+00 | 0.1371 |
56943 | ENY2 | P38T-E | Human | Esophagus | ESCC | 3.07e-40 | 2.30e+00 | 0.127 |
56943 | ENY2 | P39T-E | Human | Esophagus | ESCC | 1.10e-49 | 1.07e+00 | 0.0894 |
56943 | ENY2 | P40T-E | Human | Esophagus | ESCC | 1.42e-28 | 1.14e+00 | 0.109 |
56943 | ENY2 | P42T-E | Human | Esophagus | ESCC | 6.54e-50 | 1.49e+00 | 0.1175 |
56943 | ENY2 | P44T-E | Human | Esophagus | ESCC | 3.93e-32 | 1.16e+00 | 0.1096 |
56943 | ENY2 | P47T-E | Human | Esophagus | ESCC | 2.80e-44 | 1.19e+00 | 0.1067 |
56943 | ENY2 | P48T-E | Human | Esophagus | ESCC | 6.16e-50 | 1.21e+00 | 0.0959 |
56943 | ENY2 | P49T-E | Human | Esophagus | ESCC | 8.80e-23 | 3.12e+00 | 0.1768 |
56943 | ENY2 | P52T-E | Human | Esophagus | ESCC | 4.93e-97 | 2.11e+00 | 0.1555 |
56943 | ENY2 | P54T-E | Human | Esophagus | ESCC | 2.04e-78 | 1.89e+00 | 0.0975 |
56943 | ENY2 | P56T-E | Human | Esophagus | ESCC | 1.49e-14 | 2.05e+00 | 0.1613 |
56943 | ENY2 | P57T-E | Human | Esophagus | ESCC | 3.37e-49 | 1.16e+00 | 0.0926 |
56943 | ENY2 | P61T-E | Human | Esophagus | ESCC | 2.95e-34 | 9.38e-01 | 0.099 |
56943 | ENY2 | P62T-E | Human | Esophagus | ESCC | 3.74e-106 | 2.13e+00 | 0.1302 |
56943 | ENY2 | P65T-E | Human | Esophagus | ESCC | 2.37e-49 | 1.08e+00 | 0.0978 |
56943 | ENY2 | P74T-E | Human | Esophagus | ESCC | 2.12e-62 | 2.21e+00 | 0.1479 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003428414 | Breast | IDC | response to monosaccharide | 36/1434 | 225/18723 | 1.94e-05 | 4.83e-04 | 36 |
GO:000974314 | Breast | IDC | response to carbohydrate | 38/1434 | 253/18723 | 4.87e-05 | 1.07e-03 | 38 |
GO:000974613 | Breast | IDC | response to hexose | 33/1434 | 219/18723 | 1.39e-04 | 2.49e-03 | 33 |
GO:000974913 | Breast | IDC | response to glucose | 31/1434 | 212/18723 | 3.75e-04 | 5.35e-03 | 31 |
GO:005070812 | Breast | IDC | regulation of protein secretion | 36/1434 | 268/18723 | 6.93e-04 | 8.50e-03 | 36 |
GO:004259313 | Breast | IDC | glucose homeostasis | 34/1434 | 258/18723 | 1.34e-03 | 1.39e-02 | 34 |
GO:003350013 | Breast | IDC | carbohydrate homeostasis | 34/1434 | 259/18723 | 1.43e-03 | 1.46e-02 | 34 |
GO:000640313 | Breast | IDC | RNA localization | 27/1434 | 201/18723 | 3.04e-03 | 2.60e-02 | 27 |
GO:000167813 | Breast | IDC | cellular glucose homeostasis | 24/1434 | 172/18723 | 3.07e-03 | 2.60e-02 | 24 |
GO:007133313 | Breast | IDC | cellular response to glucose stimulus | 21/1434 | 151/18723 | 5.59e-03 | 4.07e-02 | 21 |
GO:007169212 | Breast | IDC | protein localization to extracellular region | 42/1434 | 368/18723 | 6.13e-03 | 4.38e-02 | 42 |
GO:009008711 | Breast | IDC | regulation of peptide transport | 26/1434 | 202/18723 | 6.33e-03 | 4.47e-02 | 26 |
GO:007133113 | Breast | IDC | cellular response to hexose stimulus | 21/1434 | 153/18723 | 6.50e-03 | 4.57e-02 | 21 |
GO:001583312 | Breast | IDC | peptide transport | 32/1434 | 264/18723 | 6.61e-03 | 4.62e-02 | 32 |
GO:007132213 | Breast | IDC | cellular response to carbohydrate stimulus | 22/1434 | 163/18723 | 6.62e-03 | 4.62e-02 | 22 |
GO:000930613 | Breast | IDC | protein secretion | 41/1434 | 359/18723 | 6.64e-03 | 4.63e-02 | 41 |
GO:003559213 | Breast | IDC | establishment of protein localization to extracellular region | 41/1434 | 360/18723 | 6.96e-03 | 4.81e-02 | 41 |
GO:007132613 | Breast | IDC | cellular response to monosaccharide stimulus | 21/1434 | 154/18723 | 7.00e-03 | 4.83e-02 | 21 |
GO:003428424 | Breast | DCIS | response to monosaccharide | 36/1390 | 225/18723 | 9.86e-06 | 2.60e-04 | 36 |
GO:000974324 | Breast | DCIS | response to carbohydrate | 38/1390 | 253/18723 | 2.48e-05 | 5.72e-04 | 38 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENY2 | SNV | Missense_Mutation | c.68N>T | p.Thr23Ile | p.T23I | Q9NPA8 | protein_coding | deleterious(0.02) | possibly_damaging(0.462) | TCGA-A6-6138-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENY2 | SNV | Missense_Mutation | c.61A>G | p.Ile21Val | p.I21V | Q9NPA8 | protein_coding | tolerated(0.53) | benign(0.005) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENY2 | SNV | Missense_Mutation | novel | c.41C>T | p.Ala14Val | p.A14V | Q9NPA8 | protein_coding | tolerated(0.06) | benign(0.379) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENY2 | SNV | Missense_Mutation | rs754316009 | c.44N>T | p.Ala15Val | p.A15V | Q9NPA8 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENY2 | SNV | Missense_Mutation | novel | c.179N>G | p.Glu60Gly | p.E60G | Q9NPA8 | protein_coding | tolerated(0.08) | benign(0.098) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ENY2 | SNV | Missense_Mutation | novel | c.298N>G | p.Ser100Gly | p.S100G | Q9NPA8 | protein_coding | tolerated(0.15) | benign(0) | TCGA-FI-A3PV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ENY2 | SNV | Missense_Mutation | c.282N>A | p.Phe94Leu | p.F94L | Q9NPA8 | protein_coding | tolerated(0.07) | possibly_damaging(0.752) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
ENY2 | SNV | Missense_Mutation | rs754316009 | c.44N>T | p.Ala15Val | p.A15V | Q9NPA8 | protein_coding | tolerated(0.58) | benign(0) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
ENY2 | SNV | Missense_Mutation | c.256G>C | p.Glu86Gln | p.E86Q | Q9NPA8 | protein_coding | deleterious(0) | benign(0.435) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ENY2 | SNV | Missense_Mutation | novel | c.18N>A | p.Met6Ile | p.M6I | Q9NPA8 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-CV-6441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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