Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DOPEY2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DOPEY2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DOPEY2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DOPEY2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/DOPEY2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOPEY2 | SNV | Missense_Mutation | novel | c.6487C>A | p.Pro2163Thr | p.P2163T | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.5416C>G | p.Leu1806Val | p.L1806V | Q9Y3R5 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.4835N>G | p.Asn1612Ser | p.N1612S | Q9Y3R5 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | | c.5017N>G | p.Leu1673Val | p.L1673V | Q9Y3R5 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | | c.262N>C | p.Glu88Gln | p.E88Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | | c.6664N>A | p.Glu2222Lys | p.E2222K | Q9Y3R5 | protein_coding | tolerated(0.57) | benign(0.033) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.404C>A | p.Pro135Gln | p.P135Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
DOPEY2 | insertion | Nonsense_Mutation | novel | c.6452_6453insCATTTGATAATACTTACTAGTTTTTTAT | p.Ala2152IlefsTer2 | p.A2152Ifs*2 | Q9Y3R5 | protein_coding | | | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
DOPEY2 | insertion | Nonsense_Mutation | novel | c.4966_4967insCGCAAATGCATATGCAAATGCATGTATATAATTAAC | p.Gly1656delinsAlaGlnMetHisMetGlnMetHisValTyrAsnTerArg | p.G1656delinsAQMHMQMHVYN*R | Q9Y3R5 | protein_coding | | | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
DOPEY2 | insertion | In_Frame_Ins | novel | c.2865_2866insACTCTGGTTTGGGTGACAGAGCAAGACTCCGTCTCAAAAAATAAA | p.Arg955_Ser956insThrLeuValTrpValThrGluGlnAspSerValSerLysAsnLys | p.R955_S956insTLVWVTEQDSVSKNK | Q9Y3R5 | protein_coding | | | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |