Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DDX50_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DDX50_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DDX50_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DDX50_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DDX50_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX50 | SNV | Missense_Mutation | | c.202G>A | p.Glu68Lys | p.E68K | Q9BQ39 | protein_coding | tolerated_low_confidence(0.31) | benign(0.162) | TCGA-A2-A0SW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | PD |
DDX50 | SNV | Missense_Mutation | | c.247G>T | p.Asp83Tyr | p.D83Y | Q9BQ39 | protein_coding | deleterious_low_confidence(0) | benign(0.359) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
DDX50 | SNV | Missense_Mutation | rs770794389 | c.2078N>T | p.Ser693Leu | p.S693L | Q9BQ39 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX50 | SNV | Missense_Mutation | rs767242175 | c.1133N>C | p.Ile378Thr | p.I378T | Q9BQ39 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-E2-A14S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
DDX50 | insertion | Frame_Shift_Ins | novel | c.1071_1072insGAAAGTGAGAATTTAA | p.Ala358GlufsTer37 | p.A358Efs*37 | Q9BQ39 | protein_coding | | | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
DDX50 | deletion | Frame_Shift_Del | novel | c.32delT | p.Met11ArgfsTer56 | p.M11Rfs*56 | Q9BQ39 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
DDX50 | SNV | Missense_Mutation | novel | c.466G>A | p.Gly156Arg | p.G156R | Q9BQ39 | protein_coding | deleterious(0.03) | possibly_damaging(0.623) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DDX50 | SNV | Missense_Mutation | | c.61G>C | p.Glu21Gln | p.E21Q | Q9BQ39 | protein_coding | deleterious_low_confidence(0.04) | benign(0.026) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
DDX50 | SNV | Missense_Mutation | novel | c.1259N>T | p.Gly420Val | p.G420V | Q9BQ39 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3496-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX50 | SNV | Missense_Mutation | | c.188N>C | p.Lys63Thr | p.K63T | Q9BQ39 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.932) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |