![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CYBRD1 |
Gene summary for CYBRD1 |
![]() |
Gene information | Species | Human | Gene symbol | CYBRD1 | Gene ID | 79901 |
Gene name | cytochrome b reductase 1 | |
Gene Alias | CYB561A2 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q53TN4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79901 | CYBRD1 | PTC04 | Human | Thyroid | PTC | 1.78e-23 | -4.56e-01 | 0.1927 |
79901 | CYBRD1 | PTC06 | Human | Thyroid | PTC | 1.66e-14 | -5.92e-02 | 0.2057 |
79901 | CYBRD1 | PTC07 | Human | Thyroid | PTC | 1.72e-27 | -2.02e-01 | 0.2044 |
79901 | CYBRD1 | ATC08 | Human | Thyroid | ATC | 8.87e-11 | -1.09e+00 | 0.0541 |
79901 | CYBRD1 | ATC09 | Human | Thyroid | ATC | 1.72e-19 | -7.00e-01 | 0.2871 |
79901 | CYBRD1 | ATC11 | Human | Thyroid | ATC | 4.13e-07 | -6.19e-01 | 0.3386 |
79901 | CYBRD1 | ATC13 | Human | Thyroid | ATC | 3.76e-05 | -7.23e-02 | 0.34 |
79901 | CYBRD1 | ATC1 | Human | Thyroid | ATC | 2.08e-16 | -6.81e-01 | 0.2878 |
79901 | CYBRD1 | ATC2 | Human | Thyroid | ATC | 2.33e-05 | -1.15e-01 | 0.34 |
79901 | CYBRD1 | ATC3 | Human | Thyroid | ATC | 6.70e-12 | -5.51e-01 | 0.338 |
79901 | CYBRD1 | ATC5 | Human | Thyroid | ATC | 1.24e-03 | 1.56e-02 | 0.34 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:005507613 | Breast | IDC | transition metal ion homeostasis | 23/1434 | 138/18723 | 3.20e-04 | 4.79e-03 | 23 |
GO:004691612 | Breast | IDC | cellular transition metal ion homeostasis | 20/1434 | 115/18723 | 4.35e-04 | 5.90e-03 | 20 |
GO:0010039 | Breast | IDC | response to iron ion | 8/1434 | 32/18723 | 2.32e-03 | 2.10e-02 | 8 |
GO:000682611 | Breast | IDC | iron ion transport | 11/1434 | 58/18723 | 4.10e-03 | 3.25e-02 | 11 |
GO:005507212 | Breast | IDC | iron ion homeostasis | 14/1434 | 85/18723 | 4.98e-03 | 3.77e-02 | 14 |
GO:001003824 | Breast | DCIS | response to metal ion | 65/1390 | 373/18723 | 8.03e-11 | 9.88e-09 | 65 |
GO:005507622 | Breast | DCIS | transition metal ion homeostasis | 23/1390 | 138/18723 | 2.04e-04 | 3.27e-03 | 23 |
GO:004691621 | Breast | DCIS | cellular transition metal ion homeostasis | 20/1390 | 115/18723 | 2.91e-04 | 4.27e-03 | 20 |
GO:00100391 | Breast | DCIS | response to iron ion | 8/1390 | 32/18723 | 1.90e-03 | 1.81e-02 | 8 |
GO:000682621 | Breast | DCIS | iron ion transport | 11/1390 | 58/18723 | 3.23e-03 | 2.73e-02 | 11 |
GO:005507221 | Breast | DCIS | iron ion homeostasis | 14/1390 | 85/18723 | 3.78e-03 | 3.03e-02 | 14 |
GO:005507617 | Esophagus | ESCC | transition metal ion homeostasis | 87/8552 | 138/18723 | 2.85e-05 | 2.37e-04 | 87 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:00469169 | Esophagus | ESCC | cellular transition metal ion homeostasis | 70/8552 | 115/18723 | 7.28e-04 | 3.79e-03 | 70 |
GO:00550729 | Esophagus | ESCC | iron ion homeostasis | 52/8552 | 85/18723 | 2.86e-03 | 1.21e-02 | 52 |
GO:005507610 | Oral cavity | OSCC | transition metal ion homeostasis | 81/7305 | 138/18723 | 2.13e-06 | 2.72e-05 | 81 |
GO:001003820 | Oral cavity | OSCC | response to metal ion | 188/7305 | 373/18723 | 4.34e-06 | 5.00e-05 | 188 |
GO:00469168 | Oral cavity | OSCC | cellular transition metal ion homeostasis | 64/7305 | 115/18723 | 2.13e-04 | 1.40e-03 | 64 |
GO:00550728 | Oral cavity | OSCC | iron ion homeostasis | 46/7305 | 85/18723 | 3.31e-03 | 1.42e-02 | 46 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYBRD1 | SNV | Missense_Mutation | c.787N>C | p.Glu263Gln | p.E263Q | Q53TN4 | protein_coding | deleterious(0.03) | benign(0.307) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CYBRD1 | SNV | Missense_Mutation | c.827C>T | p.Ala276Val | p.A276V | Q53TN4 | protein_coding | tolerated_low_confidence(0.15) | benign(0.01) | TCGA-AO-A1KR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
CYBRD1 | SNV | Missense_Mutation | novel | c.676C>T | p.Arg226Cys | p.R226C | Q53TN4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CYBRD1 | SNV | Missense_Mutation | c.21N>T | p.Trp7Cys | p.W7C | Q53TN4 | protein_coding | tolerated(0.18) | benign(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYBRD1 | SNV | Missense_Mutation | c.530G>A | p.Gly177Glu | p.G177E | Q53TN4 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYBRD1 | SNV | Missense_Mutation | novel | c.256N>A | p.His86Asn | p.H86N | Q53TN4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CYBRD1 | SNV | Missense_Mutation | novel | c.225N>T | p.Trp75Cys | p.W75C | Q53TN4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CYBRD1 | SNV | Missense_Mutation | c.474N>G | p.Ile158Met | p.I158M | Q53TN4 | protein_coding | tolerated(0.05) | benign(0.079) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CYBRD1 | SNV | Missense_Mutation | c.549N>G | p.Ile183Met | p.I183M | Q53TN4 | protein_coding | deleterious(0.03) | possibly_damaging(0.718) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
CYBRD1 | SNV | Missense_Mutation | novel | c.562G>T | p.Asp188Tyr | p.D188Y | Q53TN4 | protein_coding | deleterious(0.02) | benign(0) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |