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Gene: CTDNEP1 |
Gene summary for CTDNEP1 |
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Gene information | Species | Human | Gene symbol | CTDNEP1 | Gene ID | 23399 |
Gene name | CTD nuclear envelope phosphatase 1 | |
Gene Alias | DULLARD | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O95476 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23399 | CTDNEP1 | P5_S10_cSCC | Human | Skin | cSCC | 1.73e-03 | 1.57e-01 | -0.299 |
23399 | CTDNEP1 | P1_cSCC | Human | Skin | cSCC | 7.48e-27 | 9.77e-01 | 0.0292 |
23399 | CTDNEP1 | P2_cSCC | Human | Skin | cSCC | 4.02e-13 | 5.55e-01 | -0.024 |
23399 | CTDNEP1 | P4_cSCC | Human | Skin | cSCC | 2.24e-21 | 7.24e-01 | -0.00290000000000005 |
23399 | CTDNEP1 | P10_cSCC | Human | Skin | cSCC | 7.98e-18 | 8.33e-01 | 0.1017 |
23399 | CTDNEP1 | cSCC_p8 | Human | Skin | cSCC | 6.75e-05 | 1.84e-01 | -0.1971 |
23399 | CTDNEP1 | cSCC_p9 | Human | Skin | cSCC | 5.42e-04 | 1.75e-01 | -0.1991 |
23399 | CTDNEP1 | male-WTA | Human | Thyroid | PTC | 7.75e-45 | 4.35e-01 | 0.1037 |
23399 | CTDNEP1 | PTC01 | Human | Thyroid | PTC | 1.90e-06 | 1.92e-01 | 0.1899 |
23399 | CTDNEP1 | PTC03 | Human | Thyroid | PTC | 1.32e-03 | 2.07e-01 | 0.1784 |
23399 | CTDNEP1 | PTC04 | Human | Thyroid | PTC | 3.42e-19 | 2.56e-01 | 0.1927 |
23399 | CTDNEP1 | PTC05 | Human | Thyroid | PTC | 6.68e-20 | 7.77e-01 | 0.2065 |
23399 | CTDNEP1 | PTC06 | Human | Thyroid | PTC | 4.01e-28 | 7.12e-01 | 0.2057 |
23399 | CTDNEP1 | PTC07 | Human | Thyroid | PTC | 1.38e-39 | 6.11e-01 | 0.2044 |
23399 | CTDNEP1 | ATC09 | Human | Thyroid | ATC | 1.71e-02 | 1.24e-01 | 0.2871 |
23399 | CTDNEP1 | ATC11 | Human | Thyroid | ATC | 1.55e-05 | 5.03e-01 | 0.3386 |
23399 | CTDNEP1 | ATC12 | Human | Thyroid | ATC | 2.82e-16 | 5.10e-01 | 0.34 |
23399 | CTDNEP1 | ATC13 | Human | Thyroid | ATC | 8.26e-48 | 1.15e+00 | 0.34 |
23399 | CTDNEP1 | ATC2 | Human | Thyroid | ATC | 2.57e-13 | 1.26e+00 | 0.34 |
23399 | CTDNEP1 | ATC3 | Human | Thyroid | ATC | 2.13e-04 | 2.90e-01 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003450417 | Esophagus | HGIN | protein localization to nucleus | 84/2587 | 290/18723 | 1.06e-11 | 1.24e-09 | 84 |
GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
GO:000647017 | Esophagus | HGIN | protein dephosphorylation | 61/2587 | 281/18723 | 1.86e-04 | 3.51e-03 | 61 |
GO:00069975 | Esophagus | HGIN | nucleus organization | 34/2587 | 133/18723 | 2.20e-04 | 4.00e-03 | 34 |
GO:00717634 | Esophagus | HGIN | nuclear membrane organization | 12/2587 | 33/18723 | 9.97e-04 | 1.25e-02 | 12 |
GO:003011116 | Esophagus | HGIN | regulation of Wnt signaling pathway | 65/2587 | 328/18723 | 1.53e-03 | 1.77e-02 | 65 |
GO:009026310 | Esophagus | HGIN | positive regulation of canonical Wnt signaling pathway | 26/2587 | 106/18723 | 2.17e-03 | 2.25e-02 | 26 |
GO:001605516 | Esophagus | HGIN | Wnt signaling pathway | 83/2587 | 444/18723 | 2.27e-03 | 2.33e-02 | 83 |
GO:019873816 | Esophagus | HGIN | cell-cell signaling by wnt | 83/2587 | 446/18723 | 2.58e-03 | 2.55e-02 | 83 |
GO:00069983 | Esophagus | HGIN | nuclear envelope organization | 14/2587 | 47/18723 | 3.49e-03 | 3.23e-02 | 14 |
GO:003017710 | Esophagus | HGIN | positive regulation of Wnt signaling pathway | 31/2587 | 140/18723 | 4.77e-03 | 4.09e-02 | 31 |
GO:006082816 | Esophagus | HGIN | regulation of canonical Wnt signaling pathway | 50/2587 | 253/18723 | 5.27e-03 | 4.35e-02 | 50 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:000699811 | Esophagus | ESCC | nuclear envelope organization | 39/8552 | 47/18723 | 1.48e-07 | 2.35e-06 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTDNEP1 | insertion | Frame_Shift_Ins | novel | c.213_214insGGGAG | p.Leu72GlyfsTer12 | p.L72Gfs*12 | O95476 | protein_coding | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
CTDNEP1 | insertion | Frame_Shift_Ins | novel | c.657_658insCCCA | p.Met220ProfsTer11 | p.M220Pfs*11 | O95476 | protein_coding | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CTDNEP1 | SNV | Missense_Mutation | rs748108988 | c.158N>A | p.Arg53Gln | p.R53Q | O95476 | protein_coding | tolerated(0.18) | benign(0.042) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CTDNEP1 | SNV | Missense_Mutation | rs759009701 | c.697G>A | p.Val233Met | p.V233M | O95476 | protein_coding | deleterious(0) | possibly_damaging(0.756) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTDNEP1 | SNV | Missense_Mutation | c.376G>A | p.Glu126Lys | p.E126K | O95476 | protein_coding | tolerated(0.1) | possibly_damaging(0.703) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CTDNEP1 | SNV | Missense_Mutation | c.431N>C | p.Lys144Thr | p.K144T | O95476 | protein_coding | tolerated(0.13) | possibly_damaging(0.568) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CTDNEP1 | SNV | Missense_Mutation | c.7C>T | p.Arg3Trp | p.R3W | O95476 | protein_coding | tolerated_low_confidence(0.12) | benign(0.232) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CTDNEP1 | SNV | Missense_Mutation | c.376N>A | p.Glu126Lys | p.E126K | O95476 | protein_coding | tolerated(0.1) | possibly_damaging(0.703) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CTDNEP1 | SNV | Missense_Mutation | novel | c.125G>A | p.Arg42Gln | p.R42Q | O95476 | protein_coding | tolerated(0.08) | benign(0.162) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CTDNEP1 | SNV | Missense_Mutation | novel | c.609A>C | p.Lys203Asn | p.K203N | O95476 | protein_coding | deleterious(0.03) | probably_damaging(0.944) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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