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Gene: CMPK1 |
Gene summary for CMPK1 |
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Gene information | Species | Human | Gene symbol | CMPK1 | Gene ID | 51727 |
Gene name | cytidine/uridine monophosphate kinase 1 | |
Gene Alias | CK | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P30085 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51727 | CMPK1 | HCC1 | Human | Liver | HCC | 2.60e-05 | 2.66e+00 | 0.5336 |
51727 | CMPK1 | HCC2 | Human | Liver | HCC | 2.33e-11 | 4.18e+00 | 0.5341 |
51727 | CMPK1 | HCC5 | Human | Liver | HCC | 1.07e-05 | 6.87e-01 | 0.4932 |
51727 | CMPK1 | Pt13.b | Human | Liver | HCC | 9.22e-20 | 1.63e-02 | 0.0251 |
51727 | CMPK1 | Pt13.c | Human | Liver | HCC | 1.06e-02 | -3.65e-01 | 0.0076 |
51727 | CMPK1 | Pt14.a | Human | Liver | HCC | 1.52e-03 | 6.66e-02 | 0.0169 |
51727 | CMPK1 | Pt14.b | Human | Liver | HCC | 2.86e-05 | -1.00e-01 | 0.018 |
51727 | CMPK1 | S014 | Human | Liver | HCC | 4.77e-04 | 5.41e-01 | 0.2254 |
51727 | CMPK1 | S015 | Human | Liver | HCC | 2.74e-10 | 9.97e-01 | 0.2375 |
51727 | CMPK1 | S016 | Human | Liver | HCC | 5.30e-10 | 7.84e-01 | 0.2243 |
51727 | CMPK1 | S027 | Human | Liver | HCC | 6.82e-16 | 2.11e+00 | 0.2446 |
51727 | CMPK1 | S028 | Human | Liver | HCC | 5.76e-25 | 1.99e+00 | 0.2503 |
51727 | CMPK1 | S029 | Human | Liver | HCC | 5.45e-30 | 2.31e+00 | 0.2581 |
51727 | CMPK1 | C04 | Human | Oral cavity | OSCC | 4.01e-29 | 1.79e+00 | 0.2633 |
51727 | CMPK1 | C21 | Human | Oral cavity | OSCC | 7.99e-59 | 1.84e+00 | 0.2678 |
51727 | CMPK1 | C30 | Human | Oral cavity | OSCC | 2.16e-31 | 1.74e+00 | 0.3055 |
51727 | CMPK1 | C38 | Human | Oral cavity | OSCC | 8.91e-03 | 8.13e-01 | 0.172 |
51727 | CMPK1 | C43 | Human | Oral cavity | OSCC | 6.11e-62 | 1.24e+00 | 0.1704 |
51727 | CMPK1 | C46 | Human | Oral cavity | OSCC | 5.48e-37 | 1.06e+00 | 0.1673 |
51727 | CMPK1 | C51 | Human | Oral cavity | OSCC | 1.37e-18 | 1.26e+00 | 0.2674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091427 | Breast | Precancer | nucleoside triphosphate biosynthetic process | 23/1080 | 85/18723 | 2.82e-10 | 2.69e-08 | 23 |
GO:00091418 | Breast | Precancer | nucleoside triphosphate metabolic process | 26/1080 | 112/18723 | 7.72e-10 | 6.66e-08 | 26 |
GO:00196938 | Breast | Precancer | ribose phosphate metabolic process | 49/1080 | 396/18723 | 3.81e-07 | 1.78e-05 | 49 |
GO:00463907 | Breast | Precancer | ribose phosphate biosynthetic process | 30/1080 | 190/18723 | 4.75e-07 | 2.11e-05 | 30 |
GO:00092607 | Breast | Precancer | ribonucleotide biosynthetic process | 29/1080 | 182/18723 | 6.05e-07 | 2.55e-05 | 29 |
GO:00091179 | Breast | Precancer | nucleotide metabolic process | 56/1080 | 489/18723 | 7.40e-07 | 3.00e-05 | 56 |
GO:00092598 | Breast | Precancer | ribonucleotide metabolic process | 47/1080 | 385/18723 | 9.69e-07 | 3.84e-05 | 47 |
GO:00469398 | Breast | Precancer | nucleotide phosphorylation | 20/1080 | 101/18723 | 1.07e-06 | 4.18e-05 | 20 |
GO:00067539 | Breast | Precancer | nucleoside phosphate metabolic process | 56/1080 | 497/18723 | 1.24e-06 | 4.70e-05 | 56 |
GO:00091858 | Breast | Precancer | ribonucleoside diphosphate metabolic process | 20/1080 | 106/18723 | 2.37e-06 | 8.17e-05 | 20 |
GO:00061658 | Breast | Precancer | nucleoside diphosphate phosphorylation | 19/1080 | 99/18723 | 3.23e-06 | 1.05e-04 | 19 |
GO:00091328 | Breast | Precancer | nucleoside diphosphate metabolic process | 21/1080 | 124/18723 | 7.98e-06 | 2.17e-04 | 21 |
GO:00091655 | Breast | Precancer | nucleotide biosynthetic process | 32/1080 | 254/18723 | 2.72e-05 | 6.21e-04 | 32 |
GO:19012935 | Breast | Precancer | nucleoside phosphate biosynthetic process | 32/1080 | 256/18723 | 3.18e-05 | 6.97e-04 | 32 |
GO:000914214 | Breast | IDC | nucleoside triphosphate biosynthetic process | 26/1434 | 85/18723 | 4.72e-10 | 5.06e-08 | 26 |
GO:000914114 | Breast | IDC | nucleoside triphosphate metabolic process | 29/1434 | 112/18723 | 3.68e-09 | 3.03e-07 | 29 |
GO:004639013 | Breast | IDC | ribose phosphate biosynthetic process | 36/1434 | 190/18723 | 3.40e-07 | 1.73e-05 | 36 |
GO:000926013 | Breast | IDC | ribonucleotide biosynthetic process | 35/1434 | 182/18723 | 3.40e-07 | 1.73e-05 | 35 |
GO:001969314 | Breast | IDC | ribose phosphate metabolic process | 58/1434 | 396/18723 | 1.31e-06 | 5.73e-05 | 58 |
GO:000675313 | Breast | IDC | nucleoside phosphate metabolic process | 68/1434 | 497/18723 | 2.01e-06 | 8.23e-05 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00240 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa00983 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa002401 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa009831 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa002404 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0024011 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0024021 | Oral cavity | LP | Pyrimidine metabolism | 28/2418 | 58/8465 | 1.12e-03 | 5.02e-03 | 3.24e-03 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CMPK1 | SNV | Missense_Mutation | novel | c.440N>T | p.Ser147Phe | p.S147F | P30085 | protein_coding | deleterious(0.02) | benign(0.429) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
CMPK1 | SNV | Missense_Mutation | rs374502290 | c.445N>A | p.Val149Ile | p.V149I | P30085 | protein_coding | tolerated(0.05) | benign(0.018) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMPK1 | SNV | Missense_Mutation | c.363C>A | p.Phe121Leu | p.F121L | P30085 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CMPK1 | SNV | Missense_Mutation | novel | c.504N>T | p.Lys168Asn | p.K168N | P30085 | protein_coding | tolerated(0.05) | benign(0.354) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CMPK1 | SNV | Missense_Mutation | novel | c.225N>T | p.Lys75Asn | p.K75N | P30085 | protein_coding | tolerated(0.57) | benign(0.018) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CMPK1 | SNV | Missense_Mutation | novel | c.504N>T | p.Lys168Asn | p.K168N | P30085 | protein_coding | tolerated(0.05) | benign(0.354) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CMPK1 | SNV | Missense_Mutation | rs374502290 | c.445G>A | p.Val149Ile | p.V149I | P30085 | protein_coding | tolerated(0.05) | benign(0.018) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CMPK1 | SNV | Missense_Mutation | novel | c.337N>A | p.Ala113Thr | p.A113T | P30085 | protein_coding | tolerated(0.31) | benign(0.017) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMPK1 | SNV | Missense_Mutation | rs374502290 | c.445G>A | p.Val149Ile | p.V149I | P30085 | protein_coding | tolerated(0.05) | benign(0.018) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CMPK1 | SNV | Missense_Mutation | c.363N>A | p.Phe121Leu | p.F121L | P30085 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51727 | CMPK1 | KINASE, ENZYME | lamivudine | LAMIVUDINE | ||
51727 | CMPK1 | KINASE, ENZYME | cisplatin | CISPLATIN | 21642870 | |
51727 | CMPK1 | KINASE, ENZYME | gemcitabine | GEMCITABINE | 21642870,22838949,22838950,24361227 |
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