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Gene: CFAP36 |
Gene summary for CFAP36 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CFAP36 | Gene ID | 112942 |
Gene name | cilia and flagella associated protein 36 | |
Gene Alias | BARTL1 | |
Cytomap | 2p16.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96G28 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112942 | CFAP36 | PTC05 | Human | Thyroid | PTC | 4.03e-17 | 1.01e+00 | 0.2065 |
112942 | CFAP36 | PTC06 | Human | Thyroid | PTC | 2.06e-26 | 8.43e-01 | 0.2057 |
112942 | CFAP36 | PTC07 | Human | Thyroid | PTC | 3.03e-45 | 8.66e-01 | 0.2044 |
112942 | CFAP36 | ATC09 | Human | Thyroid | ATC | 3.50e-04 | -2.64e-02 | 0.2871 |
112942 | CFAP36 | ATC11 | Human | Thyroid | ATC | 2.16e-08 | 1.92e-01 | 0.3386 |
112942 | CFAP36 | ATC13 | Human | Thyroid | ATC | 3.64e-28 | 7.90e-01 | 0.34 |
112942 | CFAP36 | ATC1 | Human | Thyroid | ATC | 4.87e-05 | 5.14e-02 | 0.2878 |
112942 | CFAP36 | ATC2 | Human | Thyroid | ATC | 1.59e-05 | 5.83e-01 | 0.34 |
112942 | CFAP36 | ATC3 | Human | Thyroid | ATC | 6.14e-11 | 1.02e-01 | 0.338 |
112942 | CFAP36 | ATC4 | Human | Thyroid | ATC | 6.00e-06 | 2.67e-01 | 0.34 |
112942 | CFAP36 | ATC5 | Human | Thyroid | ATC | 1.95e-21 | 8.71e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP36 | SNV | Missense_Mutation | rs377625368 | c.745A>G | p.Ile249Val | p.I249V | Q96G28 | protein_coding | tolerated(1) | benign(0) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
CFAP36 | SNV | Missense_Mutation | c.617N>T | p.Ser206Leu | p.S206L | Q96G28 | protein_coding | tolerated(0.41) | benign(0.022) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CFAP36 | SNV | Missense_Mutation | novel | c.658N>A | p.Ala220Thr | p.A220T | Q96G28 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CFAP36 | SNV | Missense_Mutation | c.674A>T | p.Asn225Ile | p.N225I | Q96G28 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CFAP36 | SNV | Missense_Mutation | rs763494988 | c.452N>A | p.Arg151Gln | p.R151Q | Q96G28 | protein_coding | tolerated(0.05) | possibly_damaging(0.446) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | novel | c.671A>C | p.Asn224Thr | p.N224T | Q96G28 | protein_coding | tolerated(0.46) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CFAP36 | SNV | Missense_Mutation | rs763494988 | c.452N>A | p.Arg151Gln | p.R151Q | Q96G28 | protein_coding | tolerated(0.05) | possibly_damaging(0.446) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | novel | c.734N>T | p.Ala245Val | p.A245V | Q96G28 | protein_coding | tolerated(0.13) | benign(0.049) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | novel | c.500N>A | p.Gly167Asp | p.G167D | Q96G28 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CFAP36 | SNV | Missense_Mutation | c.862G>T | p.Val288Leu | p.V288L | Q96G28 | protein_coding | tolerated(0.25) | benign(0.014) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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