![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CD82 |
Gene summary for CD82 |
![]() |
Gene information | Species | Human | Gene symbol | CD82 | Gene ID | 3732 |
Gene name | CD82 molecule | |
Gene Alias | 4F9 | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P27701 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3732 | CD82 | C30 | Human | Oral cavity | OSCC | 2.84e-42 | 2.11e+00 | 0.3055 |
3732 | CD82 | C38 | Human | Oral cavity | OSCC | 2.86e-23 | 2.29e+00 | 0.172 |
3732 | CD82 | C43 | Human | Oral cavity | OSCC | 2.02e-65 | 1.40e+00 | 0.1704 |
3732 | CD82 | C46 | Human | Oral cavity | OSCC | 3.55e-77 | 1.68e+00 | 0.1673 |
3732 | CD82 | C51 | Human | Oral cavity | OSCC | 2.70e-19 | 1.31e+00 | 0.2674 |
3732 | CD82 | C57 | Human | Oral cavity | OSCC | 9.24e-20 | 8.90e-01 | 0.1679 |
3732 | CD82 | C06 | Human | Oral cavity | OSCC | 3.35e-13 | 1.79e+00 | 0.2699 |
3732 | CD82 | C07 | Human | Oral cavity | OSCC | 1.15e-18 | 2.18e+00 | 0.2491 |
3732 | CD82 | C08 | Human | Oral cavity | OSCC | 4.49e-14 | 6.35e-01 | 0.1919 |
3732 | CD82 | C86 | Human | Oral cavity | OSCC | 2.28e-02 | 7.95e-01 | 0.161 |
3732 | CD82 | C09 | Human | Oral cavity | OSCC | 1.03e-12 | 5.80e-01 | 0.1431 |
3732 | CD82 | LN22 | Human | Oral cavity | OSCC | 2.09e-04 | 8.25e-01 | 0.1733 |
3732 | CD82 | LN38 | Human | Oral cavity | OSCC | 3.40e-08 | 1.82e+00 | 0.168 |
3732 | CD82 | LN46 | Human | Oral cavity | OSCC | 1.31e-34 | 1.41e+00 | 0.1666 |
3732 | CD82 | LP15 | Human | Oral cavity | LP | 4.78e-13 | 2.80e+00 | 0.2174 |
3732 | CD82 | LP16 | Human | Oral cavity | LP | 2.83e-07 | 1.86e+00 | 0.1055 |
3732 | CD82 | LP17 | Human | Oral cavity | LP | 6.71e-09 | 1.04e+00 | 0.2349 |
3732 | CD82 | EOLP-1 | Human | Oral cavity | EOLP | 2.62e-02 | 2.49e-01 | -0.0202 |
3732 | CD82 | EOLP-2 | Human | Oral cavity | EOLP | 1.15e-03 | 3.69e-01 | -0.0203 |
3732 | CD82 | SYSMH1 | Human | Oral cavity | OSCC | 2.12e-27 | 7.92e-01 | 0.1127 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411524 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa0411534 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa041156 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa0411511 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa041159 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411514 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411523 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
hsa0411533 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD82 | SNV | Missense_Mutation | c.240N>C | p.Glu80Asp | p.E80D | P27701 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-A6-6140-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | SD | |
CD82 | SNV | Missense_Mutation | novel | c.692N>C | p.Ile231Thr | p.I231T | P27701 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CD82 | SNV | Missense_Mutation | rs766230830 | c.775N>A | p.Glu259Lys | p.E259K | P27701 | protein_coding | deleterious(0.04) | possibly_damaging(0.799) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
CD82 | SNV | Missense_Mutation | c.664N>A | p.Ala222Thr | p.A222T | P27701 | protein_coding | tolerated(0.42) | benign(0.02) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CD82 | SNV | Missense_Mutation | rs761257124 | c.37N>A | p.Leu13Ile | p.L13I | P27701 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CD82 | SNV | Missense_Mutation | novel | c.163N>A | p.Gly55Arg | p.G55R | P27701 | protein_coding | deleterious(0.03) | probably_damaging(0.978) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD82 | SNV | Missense_Mutation | c.304N>A | p.Ala102Thr | p.A102T | P27701 | protein_coding | tolerated(0.12) | possibly_damaging(0.554) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CD82 | SNV | Missense_Mutation | novel | c.547N>A | p.Asp183Asn | p.D183N | P27701 | protein_coding | tolerated(0.94) | possibly_damaging(0.494) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD82 | SNV | Missense_Mutation | c.502C>T | p.Pro168Ser | p.P168S | P27701 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD82 | SNV | Missense_Mutation | novel | c.682N>A | p.Leu228Met | p.L228M | P27701 | protein_coding | deleterious(0.02) | possibly_damaging(0.844) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3732 | CD82 | DRUGGABLE GENOME, CELL SURFACE | NERVE GROWTH FACTOR | 10353759 |
Page: 1 |