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Gene: CD151 |
Gene summary for CD151 |
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Gene information | Species | Human | Gene symbol | CD151 | Gene ID | 977 |
Gene name | CD151 molecule (Raph blood group) | |
Gene Alias | GP27 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024RCB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
977 | CD151 | P19T-E | Human | Esophagus | ESCC | 1.08e-22 | 2.94e+00 | 0.1662 |
977 | CD151 | P20T-E | Human | Esophagus | ESCC | 1.79e-43 | 1.28e+00 | 0.1124 |
977 | CD151 | P21T-E | Human | Esophagus | ESCC | 9.89e-85 | 2.14e+00 | 0.1617 |
977 | CD151 | P22T-E | Human | Esophagus | ESCC | 4.35e-65 | 1.58e+00 | 0.1236 |
977 | CD151 | P23T-E | Human | Esophagus | ESCC | 1.72e-39 | 1.56e+00 | 0.108 |
977 | CD151 | P24T-E | Human | Esophagus | ESCC | 6.72e-62 | 1.90e+00 | 0.1287 |
977 | CD151 | P26T-E | Human | Esophagus | ESCC | 1.36e-59 | 1.22e+00 | 0.1276 |
977 | CD151 | P27T-E | Human | Esophagus | ESCC | 3.64e-29 | 9.07e-01 | 0.1055 |
977 | CD151 | P28T-E | Human | Esophagus | ESCC | 7.24e-42 | 1.19e+00 | 0.1149 |
977 | CD151 | P30T-E | Human | Esophagus | ESCC | 3.74e-15 | 1.38e+00 | 0.137 |
977 | CD151 | P31T-E | Human | Esophagus | ESCC | 5.59e-61 | 1.36e+00 | 0.1251 |
977 | CD151 | P32T-E | Human | Esophagus | ESCC | 4.52e-115 | 3.49e+00 | 0.1666 |
977 | CD151 | P36T-E | Human | Esophagus | ESCC | 1.88e-24 | 1.39e+00 | 0.1187 |
977 | CD151 | P37T-E | Human | Esophagus | ESCC | 6.34e-71 | 2.35e+00 | 0.1371 |
977 | CD151 | P38T-E | Human | Esophagus | ESCC | 7.25e-09 | 8.35e-01 | 0.127 |
977 | CD151 | P39T-E | Human | Esophagus | ESCC | 1.59e-16 | 3.91e-01 | 0.0894 |
977 | CD151 | P40T-E | Human | Esophagus | ESCC | 1.55e-23 | 1.10e+00 | 0.109 |
977 | CD151 | P42T-E | Human | Esophagus | ESCC | 5.65e-33 | 1.44e+00 | 0.1175 |
977 | CD151 | P44T-E | Human | Esophagus | ESCC | 5.87e-41 | 1.82e+00 | 0.1096 |
977 | CD151 | P47T-E | Human | Esophagus | ESCC | 1.67e-43 | 1.24e+00 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00420609 | Breast | Precancer | wound healing | 48/1080 | 422/18723 | 5.48e-06 | 1.63e-04 | 48 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:00420987 | Breast | Precancer | T cell proliferation | 23/1080 | 199/18723 | 1.17e-03 | 1.27e-02 | 23 |
GO:00458076 | Breast | Precancer | positive regulation of endocytosis | 14/1080 | 100/18723 | 1.77e-03 | 1.74e-02 | 14 |
GO:004211012 | Breast | IDC | T cell activation | 64/1434 | 487/18723 | 1.49e-05 | 3.77e-04 | 64 |
GO:004206014 | Breast | IDC | wound healing | 55/1434 | 422/18723 | 7.27e-05 | 1.45e-03 | 55 |
GO:004580713 | Breast | IDC | positive regulation of endocytosis | 18/1434 | 100/18723 | 5.40e-04 | 6.96e-03 | 18 |
GO:004209812 | Breast | IDC | T cell proliferation | 28/1434 | 199/18723 | 1.29e-03 | 1.35e-02 | 28 |
GO:00301007 | Breast | IDC | regulation of endocytosis | 27/1434 | 211/18723 | 5.92e-03 | 4.26e-02 | 27 |
GO:004211021 | Breast | DCIS | T cell activation | 65/1390 | 487/18723 | 2.78e-06 | 9.42e-05 | 65 |
GO:004206024 | Breast | DCIS | wound healing | 54/1390 | 422/18723 | 6.09e-05 | 1.22e-03 | 54 |
GO:004209821 | Breast | DCIS | T cell proliferation | 29/1390 | 199/18723 | 3.64e-04 | 5.15e-03 | 29 |
GO:004580722 | Breast | DCIS | positive regulation of endocytosis | 17/1390 | 100/18723 | 1.05e-03 | 1.15e-02 | 17 |
GO:00706616 | Breast | DCIS | leukocyte proliferation | 37/1390 | 318/18723 | 4.39e-03 | 3.41e-02 | 37 |
GO:00466515 | Breast | DCIS | lymphocyte proliferation | 34/1390 | 288/18723 | 4.91e-03 | 3.70e-02 | 34 |
GO:00329434 | Breast | DCIS | mononuclear cell proliferation | 34/1390 | 291/18723 | 5.75e-03 | 4.14e-02 | 34 |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00443193 | Cervix | CC | wound healing, spreading of cells | 17/2311 | 34/18723 | 9.86e-08 | 5.25e-06 | 17 |
GO:00905053 | Cervix | CC | epiboly involved in wound healing | 17/2311 | 34/18723 | 9.86e-08 | 5.25e-06 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD151 | SNV | Missense_Mutation | c.645C>A | p.Phe215Leu | p.F215L | P48509 | protein_coding | deleterious(0.05) | possibly_damaging(0.837) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CD151 | deletion | Frame_Shift_Del | novel | c.369delN | p.Glu124ArgfsTer3 | p.E124Rfs*3 | P48509 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CD151 | SNV | Missense_Mutation | c.188N>G | p.Ile63Ser | p.I63S | P48509 | protein_coding | deleterious(0.04) | possibly_damaging(0.643) | TCGA-FU-A3TX-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD151 | SNV | Missense_Mutation | rs534240443 | c.619G>A | p.Gly207Ser | p.G207S | P48509 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CD151 | SNV | Missense_Mutation | c.641N>T | p.Thr214Ile | p.T214I | P48509 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CD151 | deletion | Frame_Shift_Del | c.533delN | p.Arg178LeufsTer43 | p.R178Lfs*43 | P48509 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
CD151 | SNV | Missense_Mutation | novel | c.209N>C | p.Val70Ala | p.V70A | P48509 | protein_coding | deleterious(0) | possibly_damaging(0.489) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CD151 | SNV | Missense_Mutation | rs758951148 | c.272N>A | p.Arg91His | p.R91H | P48509 | protein_coding | tolerated(0.56) | possibly_damaging(0.806) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD151 | SNV | Missense_Mutation | novel | c.364N>T | p.Leu122Phe | p.L122F | P48509 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD151 | SNV | Missense_Mutation | rs766766478 | c.337N>A | p.Ala113Thr | p.A113T | P48509 | protein_coding | deleterious(0) | benign(0.017) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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