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Gene: C6orf89 |
Gene summary for C6ORF89 |
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Gene information | Species | Human | Gene symbol | C6orf89 | Gene ID | 221477 |
Gene name | chromosome 6 open reading frame 89 | |
Gene Alias | BRAP | |
Cytomap | 6p21.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024RCY0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221477 | C6orf89 | Dong_P3 | Human | Prostate | Tumor | 4.86e-03 | 6.42e-02 | 0.0278 |
221477 | C6orf89 | Dong_P4 | Human | Prostate | Tumor | 1.39e-06 | 1.92e-01 | 0.0292 |
221477 | C6orf89 | Dong_P5 | Human | Prostate | Tumor | 1.02e-31 | 2.26e-01 | 0.053 |
221477 | C6orf89 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 2.82e-02 | 6.29e-01 | 0.1557 |
221477 | C6orf89 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 5.60e-08 | 5.51e-01 | 0.1633 |
221477 | C6orf89 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 6.23e-03 | 4.19e-01 | 0.1604 |
221477 | C6orf89 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.09e-02 | 3.94e-01 | 0.1621 |
221477 | C6orf89 | P1_cSCC | Human | Skin | cSCC | 2.63e-10 | 3.95e-01 | 0.0292 |
221477 | C6orf89 | P2_cSCC | Human | Skin | cSCC | 2.86e-03 | 1.50e-01 | -0.024 |
221477 | C6orf89 | P4_cSCC | Human | Skin | cSCC | 2.68e-04 | 1.91e-01 | -0.00290000000000005 |
221477 | C6orf89 | male-WTA | Human | Thyroid | PTC | 1.27e-40 | 4.70e-01 | 0.1037 |
221477 | C6orf89 | nodule-WTA | Human | Thyroid | goiters | 1.76e-02 | 3.45e-01 | 0.0534 |
221477 | C6orf89 | PTC01 | Human | Thyroid | PTC | 9.98e-13 | 2.82e-01 | 0.1899 |
221477 | C6orf89 | PTC04 | Human | Thyroid | PTC | 1.36e-10 | 3.33e-01 | 0.1927 |
221477 | C6orf89 | PTC05 | Human | Thyroid | PTC | 6.89e-17 | 6.55e-01 | 0.2065 |
221477 | C6orf89 | PTC06 | Human | Thyroid | PTC | 8.19e-42 | 9.78e-01 | 0.2057 |
221477 | C6orf89 | PTC07 | Human | Thyroid | PTC | 3.34e-38 | 6.85e-01 | 0.2044 |
221477 | C6orf89 | ATC09 | Human | Thyroid | ATC | 3.84e-06 | 1.99e-01 | 0.2871 |
221477 | C6orf89 | ATC11 | Human | Thyroid | ATC | 6.42e-10 | 4.74e-01 | 0.3386 |
221477 | C6orf89 | ATC12 | Human | Thyroid | ATC | 1.03e-23 | 3.98e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:00310583 | Esophagus | ESCC | positive regulation of histone modification | 65/8552 | 92/18723 | 1.04e-06 | 1.31e-05 | 65 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:00903122 | Esophagus | ESCC | positive regulation of protein deacetylation | 20/8552 | 25/18723 | 4.81e-04 | 2.69e-03 | 20 |
GO:00310652 | Esophagus | ESCC | positive regulation of histone deacetylation | 15/8552 | 19/18723 | 3.29e-03 | 1.35e-02 | 15 |
GO:00310631 | Esophagus | ESCC | regulation of histone deacetylation | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:00903114 | Esophagus | ESCC | regulation of protein deacetylation | 30/8552 | 48/18723 | 1.40e-02 | 4.57e-02 | 30 |
GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
GO:001657011 | Liver | Cirrhotic | histone modification | 154/4634 | 463/18723 | 1.92e-05 | 2.57e-04 | 154 |
GO:003105611 | Liver | Cirrhotic | regulation of histone modification | 59/4634 | 152/18723 | 8.28e-05 | 9.02e-04 | 59 |
GO:00457874 | Liver | Cirrhotic | positive regulation of cell cycle | 97/4634 | 313/18723 | 6.88e-03 | 3.38e-02 | 97 |
GO:0035601 | Liver | Cirrhotic | protein deacylation | 39/4634 | 112/18723 | 1.08e-02 | 4.75e-02 | 39 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf89 | SNV | Missense_Mutation | rs143348146 | c.748N>T | p.Arg250Cys | p.R250C | Q6UWU4 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
C6orf89 | SNV | Missense_Mutation | c.655N>A | p.Gly219Arg | p.G219R | Q6UWU4 | protein_coding | tolerated(0.08) | benign(0.441) | TCGA-AO-A124-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
C6orf89 | SNV | Missense_Mutation | c.772N>G | p.His258Asp | p.H258D | Q6UWU4 | protein_coding | tolerated(0.21) | benign(0.023) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
C6orf89 | SNV | Missense_Mutation | rs779924954 | c.218N>A | p.Ala73Glu | p.A73E | Q6UWU4 | protein_coding | deleterious(0) | benign(0.086) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | c.353N>G | p.Ile118Ser | p.I118S | Q6UWU4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
C6orf89 | SNV | Missense_Mutation | rs79686273 | c.979N>A | p.Asp327Asn | p.D327N | Q6UWU4 | protein_coding | tolerated(0.85) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | rs751486634 | c.923N>A | p.Arg308Gln | p.R308Q | Q6UWU4 | protein_coding | tolerated(0.33) | possibly_damaging(0.525) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | rs571648523 | c.313N>T | p.Arg105Cys | p.R105C | Q6UWU4 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | novel | c.664N>C | p.Ala222Pro | p.A222P | Q6UWU4 | protein_coding | tolerated(0.06) | benign(0.417) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C6orf89 | SNV | Missense_Mutation | novel | c.794N>T | p.Ala265Val | p.A265V | Q6UWU4 | protein_coding | tolerated(0.69) | benign(0.015) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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