![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C6orf62 |
Gene summary for C6ORF62 |
![]() |
Gene information | Species | Human | Gene symbol | C6orf62 | Gene ID | 81688 |
Gene name | chromosome 6 open reading frame 62 | |
Gene Alias | Nbla00237 | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R026 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81688 | C6orf62 | LN22 | Human | Oral cavity | OSCC | 2.48e-08 | 1.15e+00 | 0.1733 |
81688 | C6orf62 | LN46 | Human | Oral cavity | OSCC | 6.96e-07 | 5.47e-01 | 0.1666 |
81688 | C6orf62 | LP15 | Human | Oral cavity | LP | 4.98e-05 | 1.25e+00 | 0.2174 |
81688 | C6orf62 | LP17 | Human | Oral cavity | LP | 2.24e-05 | 1.05e+00 | 0.2349 |
81688 | C6orf62 | SYSMH1 | Human | Oral cavity | OSCC | 3.54e-04 | 2.50e-02 | 0.1127 |
81688 | C6orf62 | SYSMH2 | Human | Oral cavity | OSCC | 2.93e-17 | 8.19e-01 | 0.2326 |
81688 | C6orf62 | SYSMH3 | Human | Oral cavity | OSCC | 4.51e-26 | 8.69e-01 | 0.2442 |
81688 | C6orf62 | SYSMH6 | Human | Oral cavity | OSCC | 5.71e-14 | 6.96e-01 | 0.1275 |
81688 | C6orf62 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 3.73e-02 | 4.20e-01 | -0.2247 |
81688 | C6orf62 | 047563_1562-all-cells | Human | Prostate | BPH | 3.28e-05 | 4.82e-02 | 0.0791 |
81688 | C6orf62 | 048752_1579-all-cells | Human | Prostate | BPH | 1.34e-02 | 1.95e-01 | 0.1008 |
81688 | C6orf62 | Dong_P1 | Human | Prostate | Tumor | 2.30e-36 | 3.04e-01 | 0.035 |
81688 | C6orf62 | Dong_P3 | Human | Prostate | Tumor | 2.19e-37 | 5.63e-01 | 0.0278 |
81688 | C6orf62 | Dong_P4 | Human | Prostate | Tumor | 2.26e-10 | 5.05e-01 | 0.0292 |
81688 | C6orf62 | Dong_P5 | Human | Prostate | Tumor | 1.71e-34 | 1.05e-01 | 0.053 |
81688 | C6orf62 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 2.08e-03 | 4.29e-01 | 0.1633 |
81688 | C6orf62 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.71e-03 | 3.90e-01 | 0.1608 |
81688 | C6orf62 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 4.64e-02 | 3.54e-01 | 0.1602 |
81688 | C6orf62 | P5_S10_cSCC | Human | Skin | cSCC | 2.55e-04 | 1.81e-01 | -0.299 |
81688 | C6orf62 | P1_cSCC | Human | Skin | cSCC | 3.08e-40 | 1.15e+00 | 0.0292 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf62 | SNV | Missense_Mutation | c.151N>A | p.Glu51Lys | p.E51K | Q9GZU0 | protein_coding | deleterious(0.04) | probably_damaging(0.981) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
C6orf62 | SNV | Missense_Mutation | c.568C>G | p.Pro190Ala | p.P190A | Q9GZU0 | protein_coding | tolerated(0.13) | possibly_damaging(0.508) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
C6orf62 | SNV | Missense_Mutation | c.151N>A | p.Glu51Lys | p.E51K | Q9GZU0 | protein_coding | deleterious(0.04) | probably_damaging(0.981) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
C6orf62 | SNV | Missense_Mutation | novel | c.503N>T | p.Gly168Val | p.G168V | Q9GZU0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf62 | SNV | Missense_Mutation | novel | c.205N>G | p.Lys69Glu | p.K69E | Q9GZU0 | protein_coding | tolerated(0.31) | benign(0.133) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf62 | SNV | Missense_Mutation | novel | c.287N>A | p.Arg96Gln | p.R96Q | Q9GZU0 | protein_coding | tolerated(0.15) | probably_damaging(0.947) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
C6orf62 | SNV | Missense_Mutation | rs746089400 | c.671G>A | p.Arg224His | p.R224H | Q9GZU0 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C6orf62 | insertion | Frame_Shift_Ins | novel | c.69_70insA | p.Glu24ArgfsTer5 | p.E24Rfs*5 | Q9GZU0 | protein_coding | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | ||
C6orf62 | SNV | Missense_Mutation | c.353N>A | p.Arg118Gln | p.R118Q | Q9GZU0 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
C6orf62 | SNV | Missense_Mutation | novel | c.498G>T | p.Lys166Asn | p.K166N | Q9GZU0 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |