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Gene: C14orf2 |
Gene summary for C14ORF2 |
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Gene information | Species | Human | Gene symbol | C14orf2 | Gene ID | 9556 |
Gene name | ATP synthase membrane subunit j | |
Gene Alias | 6.8PL | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R6N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9556 | C14orf2 | P17T-E | Human | Esophagus | ESCC | 8.91e-29 | 1.67e+00 | 0.1278 |
9556 | C14orf2 | P19T-E | Human | Esophagus | ESCC | 1.36e-11 | 1.74e+00 | 0.1662 |
9556 | C14orf2 | P20T-E | Human | Esophagus | ESCC | 1.87e-38 | 1.17e+00 | 0.1124 |
9556 | C14orf2 | P21T-E | Human | Esophagus | ESCC | 1.18e-55 | 1.43e+00 | 0.1617 |
9556 | C14orf2 | P22T-E | Human | Esophagus | ESCC | 8.34e-72 | 1.58e+00 | 0.1236 |
9556 | C14orf2 | P23T-E | Human | Esophagus | ESCC | 3.12e-51 | 1.86e+00 | 0.108 |
9556 | C14orf2 | P24T-E | Human | Esophagus | ESCC | 7.40e-24 | 8.07e-01 | 0.1287 |
9556 | C14orf2 | P26T-E | Human | Esophagus | ESCC | 3.83e-63 | 1.71e+00 | 0.1276 |
9556 | C14orf2 | P27T-E | Human | Esophagus | ESCC | 2.07e-54 | 1.58e+00 | 0.1055 |
9556 | C14orf2 | P28T-E | Human | Esophagus | ESCC | 5.47e-74 | 2.18e+00 | 0.1149 |
9556 | C14orf2 | P30T-E | Human | Esophagus | ESCC | 3.42e-38 | 1.83e+00 | 0.137 |
9556 | C14orf2 | P31T-E | Human | Esophagus | ESCC | 1.04e-48 | 1.33e+00 | 0.1251 |
9556 | C14orf2 | P32T-E | Human | Esophagus | ESCC | 2.53e-66 | 1.81e+00 | 0.1666 |
9556 | C14orf2 | P36T-E | Human | Esophagus | ESCC | 9.47e-24 | 1.23e+00 | 0.1187 |
9556 | C14orf2 | P37T-E | Human | Esophagus | ESCC | 3.57e-54 | 1.79e+00 | 0.1371 |
9556 | C14orf2 | P38T-E | Human | Esophagus | ESCC | 2.57e-10 | 8.21e-01 | 0.127 |
9556 | C14orf2 | P39T-E | Human | Esophagus | ESCC | 2.74e-24 | 7.09e-01 | 0.0894 |
9556 | C14orf2 | P40T-E | Human | Esophagus | ESCC | 1.21e-15 | 9.18e-01 | 0.109 |
9556 | C14orf2 | P42T-E | Human | Esophagus | ESCC | 2.72e-22 | 1.13e+00 | 0.1175 |
9556 | C14orf2 | P44T-E | Human | Esophagus | ESCC | 1.60e-12 | 4.98e-01 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C14orf2 | SNV | Missense_Mutation | rs749080256 | c.154N>A | p.Val52Ile | p.V52I | P56378 | protein_coding | tolerated(0.38) | benign(0.107) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
C14orf2 | SNV | Missense_Mutation | c.182N>T | p.Arg61Ile | p.R61I | P56378 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C14orf2 | SNV | Missense_Mutation | c.42N>G | p.Phe14Leu | p.F14L | P56378 | protein_coding | tolerated_low_confidence(0.73) | benign(0) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
C14orf2 | SNV | Missense_Mutation | novel | c.136G>T | p.Gly46Trp | p.G46W | P56378 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C14orf2 | SNV | Missense_Mutation | novel | c.101N>C | p.Tyr34Ser | p.Y34S | P56378 | protein_coding | tolerated(0.08) | possibly_damaging(0.747) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C14orf2 | SNV | Missense_Mutation | novel | c.83N>G | p.Ile28Ser | p.I28S | P56378 | protein_coding | tolerated(0.25) | benign(0.373) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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