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Gene: C12orf10 |
Gene summary for C12ORF10 |
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Gene information | Species | Human | Gene symbol | C12orf10 | Gene ID | 60314 |
Gene name | MYG1 exonuclease | |
Gene Alias | C12orf10 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86UA3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60314 | C12orf10 | SYSMH4 | Human | Oral cavity | OSCC | 3.04e-06 | 2.51e-01 | 0.1226 |
60314 | C12orf10 | SYSMH5 | Human | Oral cavity | OSCC | 1.28e-04 | 2.75e-01 | 0.0647 |
60314 | C12orf10 | SYSMH6 | Human | Oral cavity | OSCC | 6.19e-09 | 4.60e-01 | 0.1275 |
60314 | C12orf10 | P4_S8_cSCC | Human | Skin | cSCC | 2.64e-07 | 1.01e-01 | -0.3095 |
60314 | C12orf10 | P5_S10_cSCC | Human | Skin | cSCC | 2.42e-06 | 3.25e-02 | -0.299 |
60314 | C12orf10 | P1_cSCC | Human | Skin | cSCC | 2.63e-08 | 6.60e-01 | 0.0292 |
60314 | C12orf10 | P2_cSCC | Human | Skin | cSCC | 4.09e-09 | 4.62e-01 | -0.024 |
60314 | C12orf10 | P4_cSCC | Human | Skin | cSCC | 1.25e-17 | 4.28e-01 | -0.00290000000000005 |
60314 | C12orf10 | P10_cSCC | Human | Skin | cSCC | 1.18e-04 | 4.11e-01 | 0.1017 |
60314 | C12orf10 | cSCC_p8 | Human | Skin | cSCC | 1.31e-05 | 1.35e-02 | -0.1971 |
60314 | C12orf10 | cSCC_p9 | Human | Skin | cSCC | 7.18e-04 | 3.56e-02 | -0.1991 |
60314 | C12orf10 | male-WTA | Human | Thyroid | PTC | 1.86e-14 | 1.27e-01 | 0.1037 |
60314 | C12orf10 | PTC01 | Human | Thyroid | PTC | 1.24e-19 | 3.86e-01 | 0.1899 |
60314 | C12orf10 | PTC04 | Human | Thyroid | PTC | 2.69e-09 | 1.78e-01 | 0.1927 |
60314 | C12orf10 | PTC05 | Human | Thyroid | PTC | 1.57e-14 | 6.90e-01 | 0.2065 |
60314 | C12orf10 | PTC06 | Human | Thyroid | PTC | 5.95e-26 | 6.55e-01 | 0.2057 |
60314 | C12orf10 | PTC07 | Human | Thyroid | PTC | 1.40e-36 | 7.42e-01 | 0.2044 |
60314 | C12orf10 | ATC09 | Human | Thyroid | ATC | 1.81e-08 | 3.62e-01 | 0.2871 |
60314 | C12orf10 | ATC11 | Human | Thyroid | ATC | 4.74e-02 | 4.29e-01 | 0.3386 |
60314 | C12orf10 | ATC12 | Human | Thyroid | ATC | 4.94e-17 | 4.51e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C12orf10 | deletion | Frame_Shift_Del | novel | c.418delN | p.His141ThrfsTer51 | p.H141Tfs*51 | Q9HB07 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C12orf10 | SNV | Missense_Mutation | rs778692195 | c.295G>A | p.Asp99Asn | p.D99N | Q9HB07 | protein_coding | deleterious(0.03) | benign(0.333) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C12orf10 | SNV | Missense_Mutation | c.704A>G | p.Tyr235Cys | p.Y235C | Q9HB07 | protein_coding | deleterious(0) | benign(0.416) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
C12orf10 | SNV | Missense_Mutation | c.316N>A | p.Asp106Asn | p.D106N | Q9HB07 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C12orf10 | SNV | Missense_Mutation | novel | c.1040G>A | p.Gly347Asp | p.G347D | Q9HB07 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C12orf10 | SNV | Missense_Mutation | c.1033N>A | p.Ala345Thr | p.A345T | Q9HB07 | protein_coding | tolerated(0.09) | benign(0.078) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C12orf10 | SNV | Missense_Mutation | rs202213306 | c.970N>T | p.Arg324Trp | p.R324W | Q9HB07 | protein_coding | deleterious(0.01) | possibly_damaging(0.839) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
C12orf10 | SNV | Missense_Mutation | c.713N>A | p.Ser238Asn | p.S238N | Q9HB07 | protein_coding | deleterious(0.01) | possibly_damaging(0.542) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |
C12orf10 | SNV | Missense_Mutation | rs138116397 | c.1088N>A | p.Arg363His | p.R363H | Q9HB07 | protein_coding | deleterious(0.02) | possibly_damaging(0.594) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C12orf10 | SNV | Missense_Mutation | rs142439022 | c.395C>T | p.Ala132Val | p.A132V | Q9HB07 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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