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Gene: BUB3 |
Gene summary for BUB3 |
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Gene information | Species | Human | Gene symbol | BUB3 | Gene ID | 9184 |
Gene name | BUB3 mitotic checkpoint protein | |
Gene Alias | BUB3L | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A140VJF3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9184 | BUB3 | LP15 | Human | Oral cavity | LP | 7.48e-06 | 1.21e+00 | 0.2174 |
9184 | BUB3 | LP16 | Human | Oral cavity | LP | 1.08e-02 | 1.22e+00 | 0.1055 |
9184 | BUB3 | LP17 | Human | Oral cavity | LP | 3.73e-02 | 9.07e-01 | 0.2349 |
9184 | BUB3 | SYSMH1 | Human | Oral cavity | OSCC | 8.29e-12 | 5.17e-01 | 0.1127 |
9184 | BUB3 | SYSMH2 | Human | Oral cavity | OSCC | 1.09e-27 | 1.22e+00 | 0.2326 |
9184 | BUB3 | SYSMH3 | Human | Oral cavity | OSCC | 2.85e-47 | 1.57e+00 | 0.2442 |
9184 | BUB3 | SYSMH4 | Human | Oral cavity | OSCC | 8.15e-03 | 1.60e-01 | 0.1226 |
9184 | BUB3 | SYSMH5 | Human | Oral cavity | OSCC | 3.18e-08 | 4.37e-01 | 0.0647 |
9184 | BUB3 | SYSMH6 | Human | Oral cavity | OSCC | 7.85e-08 | 5.67e-01 | 0.1275 |
9184 | BUB3 | P4_S8_cSCC | Human | Skin | cSCC | 6.64e-03 | -9.14e-02 | -0.3095 |
9184 | BUB3 | P5_S10_cSCC | Human | Skin | cSCC | 7.58e-04 | -1.06e-01 | -0.299 |
9184 | BUB3 | P1_cSCC | Human | Skin | cSCC | 1.98e-29 | 1.20e+00 | 0.0292 |
9184 | BUB3 | P2_cSCC | Human | Skin | cSCC | 1.99e-15 | 8.14e-01 | -0.024 |
9184 | BUB3 | P4_cSCC | Human | Skin | cSCC | 2.20e-37 | 1.22e+00 | -0.00290000000000005 |
9184 | BUB3 | P10_cSCC | Human | Skin | cSCC | 3.72e-46 | 1.73e+00 | 0.1017 |
9184 | BUB3 | cSCC_p8 | Human | Skin | cSCC | 1.83e-03 | -6.20e-02 | -0.1971 |
9184 | BUB3 | cSCC_p9 | Human | Skin | cSCC | 1.25e-02 | -9.80e-02 | -0.1991 |
9184 | BUB3 | male-WTA | Human | Thyroid | PTC | 6.10e-39 | 2.75e-01 | 0.1037 |
9184 | BUB3 | PTC01 | Human | Thyroid | PTC | 2.62e-17 | 1.91e-01 | 0.1899 |
9184 | BUB3 | PTC04 | Human | Thyroid | PTC | 7.34e-20 | 1.97e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00106392 | Colorectum | MSS | negative regulation of organelle organization | 102/3467 | 348/18723 | 5.36e-07 | 2.05e-05 | 102 |
GO:00330441 | Colorectum | MSS | regulation of chromosome organization | 55/3467 | 187/18723 | 1.86e-04 | 2.63e-03 | 55 |
GO:00073461 | Colorectum | MSS | regulation of mitotic cell cycle | 108/3467 | 457/18723 | 3.30e-03 | 2.50e-02 | 108 |
GO:01400141 | Colorectum | MSS | mitotic nuclear division | 70/3467 | 287/18723 | 7.48e-03 | 4.72e-02 | 70 |
GO:00330449 | Esophagus | HGIN | regulation of chromosome organization | 51/2587 | 187/18723 | 8.91e-07 | 3.61e-05 | 51 |
GO:001063920 | Esophagus | HGIN | negative regulation of organelle organization | 79/2587 | 348/18723 | 4.12e-06 | 1.37e-04 | 79 |
GO:000734610 | Esophagus | HGIN | regulation of mitotic cell cycle | 98/2587 | 457/18723 | 4.39e-06 | 1.42e-04 | 98 |
GO:00447729 | Esophagus | HGIN | mitotic cell cycle phase transition | 89/2587 | 424/18723 | 2.80e-05 | 7.21e-04 | 89 |
GO:19019906 | Esophagus | HGIN | regulation of mitotic cell cycle phase transition | 65/2587 | 299/18723 | 1.12e-04 | 2.36e-03 | 65 |
GO:01400146 | Esophagus | HGIN | mitotic nuclear division | 61/2587 | 287/18723 | 3.38e-04 | 5.55e-03 | 61 |
GO:00070593 | Esophagus | HGIN | chromosome segregation | 71/2587 | 346/18723 | 3.47e-04 | 5.62e-03 | 71 |
GO:00345024 | Esophagus | HGIN | protein localization to chromosome | 24/2587 | 92/18723 | 1.29e-03 | 1.54e-02 | 24 |
GO:00459305 | Esophagus | HGIN | negative regulation of mitotic cell cycle | 49/2587 | 235/18723 | 1.88e-03 | 2.01e-02 | 49 |
GO:19019915 | Esophagus | HGIN | negative regulation of mitotic cell cycle phase transition | 39/2587 | 179/18723 | 2.31e-03 | 2.36e-02 | 39 |
GO:00000703 | Esophagus | HGIN | mitotic sister chromatid segregation | 36/2587 | 168/18723 | 4.42e-03 | 3.87e-02 | 36 |
GO:19019876 | Esophagus | HGIN | regulation of cell cycle phase transition | 72/2587 | 390/18723 | 5.78e-03 | 4.70e-02 | 72 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051662 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa051663 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa0516639 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa041109 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa05166114 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa0411016 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0516614 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa041104 | Liver | Cirrhotic | Cell cycle | 61/2530 | 157/8465 | 9.53e-03 | 3.21e-02 | 1.98e-02 | 61 |
hsa0516615 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa0411011 | Liver | Cirrhotic | Cell cycle | 61/2530 | 157/8465 | 9.53e-03 | 3.21e-02 | 1.98e-02 | 61 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BUB3 | SNV | Missense_Mutation | novel | c.358G>C | p.Val120Leu | p.V120L | O43684 | protein_coding | tolerated(0.56) | benign(0.052) | TCGA-A2-A3XX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
BUB3 | SNV | Missense_Mutation | c.637G>A | p.Glu213Lys | p.E213K | O43684 | protein_coding | deleterious(0.02) | possibly_damaging(0.835) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BUB3 | SNV | Missense_Mutation | c.548G>A | p.Arg183His | p.R183H | O43684 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
BUB3 | SNV | Missense_Mutation | c.169G>C | p.Gly57Arg | p.G57R | O43684 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
BUB3 | SNV | Missense_Mutation | novel | c.715G>A | p.Ala239Thr | p.A239T | O43684 | protein_coding | tolerated(0.05) | possibly_damaging(0.606) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BUB3 | SNV | Missense_Mutation | c.506N>G | p.Tyr169Cys | p.Y169C | O43684 | protein_coding | tolerated(0.18) | possibly_damaging(0.598) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BUB3 | SNV | Missense_Mutation | c.550N>C | p.Cys184Arg | p.C184R | O43684 | protein_coding | tolerated(0.06) | possibly_damaging(0.736) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BUB3 | SNV | Missense_Mutation | c.548N>A | p.Arg183His | p.R183H | O43684 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BUB3 | insertion | In_Frame_Ins | novel | c.196_197insGGC | p.Asp66delinsGlyHis | p.D66delinsGH | O43684 | protein_coding | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BUB3 | insertion | Frame_Shift_Ins | novel | c.690_691insGGTAA | p.Ile231GlyfsTer30 | p.I231Gfs*30 | O43684 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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