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Gene: BAG3 |
Gene summary for BAG3 |
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Gene information | Species | Human | Gene symbol | BAG3 | Gene ID | 9531 |
Gene name | BAG cochaperone 3 | |
Gene Alias | BAG-3 | |
Cytomap | 10q26.11 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | O95817 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9531 | BAG3 | NEOLP-2 | Human | Oral cavity | NEOLP | 4.62e-06 | 3.16e-01 | -0.0196 |
9531 | BAG3 | NEOLP-3 | Human | Oral cavity | NEOLP | 3.02e-03 | 2.62e-01 | -0.0191 |
9531 | BAG3 | SYSMH1 | Human | Oral cavity | OSCC | 4.55e-14 | 6.82e-01 | 0.1127 |
9531 | BAG3 | SYSMH2 | Human | Oral cavity | OSCC | 1.77e-16 | 1.06e+00 | 0.2326 |
9531 | BAG3 | SYSMH3 | Human | Oral cavity | OSCC | 2.59e-26 | 7.59e-01 | 0.2442 |
9531 | BAG3 | SYSMH4 | Human | Oral cavity | OSCC | 4.37e-05 | 2.27e-01 | 0.1226 |
9531 | BAG3 | SYSMH5 | Human | Oral cavity | OSCC | 2.28e-03 | 2.46e-01 | 0.0647 |
9531 | BAG3 | SYSMH6 | Human | Oral cavity | OSCC | 4.98e-10 | 6.38e-01 | 0.1275 |
9531 | BAG3 | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 6.28e-05 | 1.26e+00 | -0.1771 |
9531 | BAG3 | GSM5252127_BPH283PrSF_Via | Human | Prostate | BPH | 3.52e-12 | 1.59e+00 | -0.1453 |
9531 | BAG3 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 2.48e-06 | 1.41e+00 | -0.1688 |
9531 | BAG3 | GSM5252129_BPH327PrSF_Via | Human | Prostate | BPH | 6.47e-05 | 1.30e+00 | -0.1697 |
9531 | BAG3 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 2.67e-05 | -3.81e-01 | -0.1972 |
9531 | BAG3 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 4.43e-04 | 1.37e+00 | -0.23 |
9531 | BAG3 | 047563_1562-all-cells | Human | Prostate | BPH | 5.92e-09 | -3.33e-01 | 0.0791 |
9531 | BAG3 | 048752_1579-all-cells | Human | Prostate | BPH | 7.94e-07 | -9.20e-02 | 0.1008 |
9531 | BAG3 | 052095_1628-all-cells | Human | Prostate | BPH | 8.32e-12 | -5.02e-01 | 0.1032 |
9531 | BAG3 | 052097_1595-all-cells | Human | Prostate | BPH | 1.08e-04 | -3.87e-01 | 0.0972 |
9531 | BAG3 | Dong_P1 | Human | Prostate | Tumor | 2.79e-39 | -4.40e-01 | 0.035 |
9531 | BAG3 | Dong_P3 | Human | Prostate | Tumor | 1.35e-18 | -4.16e-01 | 0.0278 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:004361810 | Cervix | CC | regulation of transcription from RNA polymerase II promoter in response to stress | 21/2311 | 47/18723 | 3.85e-08 | 2.53e-06 | 21 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:004362010 | Cervix | CC | regulation of DNA-templated transcription in response to stress | 22/2311 | 53/18723 | 9.29e-08 | 5.19e-06 | 22 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:190495110 | Cervix | CC | positive regulation of establishment of protein localization | 73/2311 | 319/18723 | 9.69e-08 | 5.25e-06 | 73 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:009719110 | Cervix | CC | extrinsic apoptotic signaling pathway | 52/2311 | 219/18723 | 2.06e-06 | 6.34e-05 | 52 |
GO:000660510 | Cervix | CC | protein targeting | 68/2311 | 314/18723 | 2.17e-06 | 6.55e-05 | 68 |
GO:00468229 | Cervix | CC | regulation of nucleocytoplasmic transport | 31/2311 | 106/18723 | 2.68e-06 | 7.87e-05 | 31 |
GO:00903167 | Cervix | CC | positive regulation of intracellular protein transport | 41/2311 | 160/18723 | 3.24e-06 | 8.80e-05 | 41 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:000698610 | Cervix | CC | response to unfolded protein | 36/2311 | 137/18723 | 6.83e-06 | 1.63e-04 | 36 |
GO:00712148 | Cervix | CC | cellular response to abiotic stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAG3 | SNV | Missense_Mutation | rs747274078 | c.289N>T | p.Pro97Ser | p.P97S | O95817 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0XO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BAG3 | insertion | Frame_Shift_Ins | novel | c.1428_1429insATCCGCAAAGAGGTGGATTCTAAAC | p.Arg477IlefsTer27 | p.R477Ifs*27 | O95817 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
BAG3 | insertion | In_Frame_Ins | novel | c.456_457insGCTGGGATTACAGGCACC | p.Gly152_Gln153insAlaGlyIleThrGlyThr | p.G152_Q153insAGITGT | O95817 | protein_coding | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BAG3 | SNV | Missense_Mutation | novel | c.637G>A | p.Glu213Lys | p.E213K | O95817 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG3 | SNV | Missense_Mutation | novel | c.1091T>C | p.Val364Ala | p.V364A | O95817 | protein_coding | tolerated(0.15) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG3 | SNV | Missense_Mutation | rs876657746 | c.362N>A | p.Arg121Gln | p.R121Q | O95817 | protein_coding | deleterious(0.05) | probably_damaging(0.944) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BAG3 | SNV | Missense_Mutation | rs144585878 | c.880N>T | p.Arg294Cys | p.R294C | O95817 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
BAG3 | SNV | Missense_Mutation | novel | c.1290N>T | p.Glu430Asp | p.E430D | O95817 | protein_coding | tolerated(0.06) | benign(0.114) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BAG3 | SNV | Missense_Mutation | c.7N>A | p.Ala3Thr | p.A3T | O95817 | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BAG3 | SNV | Missense_Mutation | c.11C>T | p.Ala4Val | p.A4V | O95817 | protein_coding | deleterious(0.01) | benign(0.242) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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