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Gene: AURKAIP1 |
Gene summary for AURKAIP1 |
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Gene information | Species | Human | Gene symbol | AURKAIP1 | Gene ID | 54998 |
Gene name | aurora kinase A interacting protein 1 | |
Gene Alias | AIP | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A024R0F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54998 | AURKAIP1 | LZE21T | Human | Esophagus | ESCC | 1.71e-07 | 9.80e-01 | 0.0655 |
54998 | AURKAIP1 | LZE6T | Human | Esophagus | ESCC | 4.06e-14 | 8.54e-01 | 0.0845 |
54998 | AURKAIP1 | P1T-E | Human | Esophagus | ESCC | 7.53e-20 | 1.27e+00 | 0.0875 |
54998 | AURKAIP1 | P2T-E | Human | Esophagus | ESCC | 1.42e-64 | 1.48e+00 | 0.1177 |
54998 | AURKAIP1 | P4T-E | Human | Esophagus | ESCC | 4.98e-84 | 2.72e+00 | 0.1323 |
54998 | AURKAIP1 | P5T-E | Human | Esophagus | ESCC | 1.33e-93 | 1.92e+00 | 0.1327 |
54998 | AURKAIP1 | P8T-E | Human | Esophagus | ESCC | 1.17e-78 | 1.85e+00 | 0.0889 |
54998 | AURKAIP1 | P9T-E | Human | Esophagus | ESCC | 4.83e-47 | 1.23e+00 | 0.1131 |
54998 | AURKAIP1 | P10T-E | Human | Esophagus | ESCC | 5.19e-72 | 1.49e+00 | 0.116 |
54998 | AURKAIP1 | P11T-E | Human | Esophagus | ESCC | 3.35e-24 | 1.46e+00 | 0.1426 |
54998 | AURKAIP1 | P12T-E | Human | Esophagus | ESCC | 1.10e-56 | 1.13e+00 | 0.1122 |
54998 | AURKAIP1 | P15T-E | Human | Esophagus | ESCC | 2.19e-60 | 1.36e+00 | 0.1149 |
54998 | AURKAIP1 | P16T-E | Human | Esophagus | ESCC | 4.59e-36 | 7.58e-01 | 0.1153 |
54998 | AURKAIP1 | P17T-E | Human | Esophagus | ESCC | 3.11e-40 | 1.83e+00 | 0.1278 |
54998 | AURKAIP1 | P19T-E | Human | Esophagus | ESCC | 1.34e-24 | 2.04e+00 | 0.1662 |
54998 | AURKAIP1 | P20T-E | Human | Esophagus | ESCC | 3.50e-55 | 1.31e+00 | 0.1124 |
54998 | AURKAIP1 | P21T-E | Human | Esophagus | ESCC | 3.08e-107 | 2.65e+00 | 0.1617 |
54998 | AURKAIP1 | P22T-E | Human | Esophagus | ESCC | 3.42e-71 | 1.37e+00 | 0.1236 |
54998 | AURKAIP1 | P23T-E | Human | Esophagus | ESCC | 2.35e-79 | 2.14e+00 | 0.108 |
54998 | AURKAIP1 | P24T-E | Human | Esophagus | ESCC | 1.05e-79 | 1.63e+00 | 0.1287 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:004586214 | Breast | IDC | positive regulation of proteolysis | 66/1434 | 372/18723 | 9.76e-11 | 1.29e-08 | 66 |
GO:00073465 | Breast | IDC | regulation of mitotic cell cycle | 51/1434 | 457/18723 | 4.30e-03 | 3.35e-02 | 51 |
GO:004586224 | Breast | DCIS | positive regulation of proteolysis | 65/1390 | 372/18723 | 7.13e-11 | 9.17e-09 | 65 |
GO:000734612 | Breast | DCIS | regulation of mitotic cell cycle | 52/1390 | 457/18723 | 1.38e-03 | 1.43e-02 | 52 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:00106399 | Cervix | CC | negative regulation of organelle organization | 68/2311 | 348/18723 | 7.40e-05 | 1.03e-03 | 68 |
GO:00457862 | Cervix | CC | negative regulation of cell cycle | 67/2311 | 385/18723 | 2.21e-03 | 1.59e-02 | 67 |
GO:00459302 | Cervix | CC | negative regulation of mitotic cell cycle | 44/2311 | 235/18723 | 3.02e-03 | 1.99e-02 | 44 |
GO:01400143 | Cervix | CC | mitotic nuclear division | 50/2311 | 287/18723 | 7.27e-03 | 3.91e-02 | 50 |
GO:00109482 | Cervix | CC | negative regulation of cell cycle process | 51/2311 | 294/18723 | 7.35e-03 | 3.94e-02 | 51 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:004586225 | Cervix | N_HPV | positive regulation of proteolysis | 29/534 | 372/18723 | 1.08e-06 | 5.80e-05 | 29 |
GO:001063914 | Cervix | N_HPV | negative regulation of organelle organization | 21/534 | 348/18723 | 1.08e-03 | 1.25e-02 | 21 |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:00458621 | Colorectum | SER | positive regulation of proteolysis | 106/2897 | 372/18723 | 8.40e-11 | 1.20e-08 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AURKAIP1 | SNV | Missense_Mutation | rs751926763 | c.451C>T | p.Arg151Trp | p.R151W | Q9NWT8 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-A7-A3IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
AURKAIP1 | SNV | Missense_Mutation | novel | c.10N>C | p.Gly4Arg | p.G4R | Q9NWT8 | protein_coding | tolerated(0.34) | benign(0.018) | TCGA-C8-A3M8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
AURKAIP1 | SNV | Missense_Mutation | novel | c.376N>G | p.Gln126Glu | p.Q126E | Q9NWT8 | protein_coding | tolerated(0.24) | possibly_damaging(0.446) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
AURKAIP1 | SNV | Missense_Mutation | novel | c.502A>C | p.Lys168Gln | p.K168Q | Q9NWT8 | protein_coding | deleterious(0.04) | benign(0.444) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AURKAIP1 | SNV | Missense_Mutation | rs753960121 | c.559N>A | p.Glu187Lys | p.E187K | Q9NWT8 | protein_coding | tolerated(0.35) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AURKAIP1 | SNV | Missense_Mutation | c.482N>T | p.Arg161Leu | p.R161L | Q9NWT8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AURKAIP1 | deletion | Frame_Shift_Del | novel | c.145_152delGCCTCTCT | p.Ala49ProfsTer66 | p.A49Pfs*66 | Q9NWT8 | protein_coding | TCGA-85-8287-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
AURKAIP1 | SNV | Missense_Mutation | novel | c.77N>G | p.Ser26Cys | p.S26C | Q9NWT8 | protein_coding | deleterious(0.05) | possibly_damaging(0.533) | TCGA-T2-A6WZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cetuximab | PD |
AURKAIP1 | SNV | Missense_Mutation | c.209C>G | p.Ser70Cys | p.S70C | Q9NWT8 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-J9-A52E-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | zoladex | SD | |
AURKAIP1 | SNV | Missense_Mutation | novel | c.208T>G | p.Ser70Ala | p.S70A | Q9NWT8 | protein_coding | tolerated(0.22) | benign(0.001) | TCGA-XJ-A83F-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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