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Gene: ATP5A1 |
Gene summary for ATP5A1 |
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Gene information | Species | Human | Gene symbol | ATP5A1 | Gene ID | 498 |
Gene name | ATP synthase F1 subunit alpha | |
Gene Alias | ATP5A | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | P25705 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
498 | ATP5A1 | P27T-E | Human | Esophagus | ESCC | 1.04e-35 | 1.37e+00 | 0.1055 |
498 | ATP5A1 | P28T-E | Human | Esophagus | ESCC | 2.07e-29 | 1.41e+00 | 0.1149 |
498 | ATP5A1 | P30T-E | Human | Esophagus | ESCC | 1.94e-41 | 2.11e+00 | 0.137 |
498 | ATP5A1 | P31T-E | Human | Esophagus | ESCC | 4.79e-35 | 1.22e+00 | 0.1251 |
498 | ATP5A1 | P32T-E | Human | Esophagus | ESCC | 7.68e-40 | 1.45e+00 | 0.1666 |
498 | ATP5A1 | P36T-E | Human | Esophagus | ESCC | 4.29e-17 | 1.10e+00 | 0.1187 |
498 | ATP5A1 | P37T-E | Human | Esophagus | ESCC | 2.29e-33 | 1.27e+00 | 0.1371 |
498 | ATP5A1 | P39T-E | Human | Esophagus | ESCC | 1.15e-11 | 7.31e-01 | 0.0894 |
498 | ATP5A1 | P40T-E | Human | Esophagus | ESCC | 8.32e-08 | 6.74e-01 | 0.109 |
498 | ATP5A1 | P42T-E | Human | Esophagus | ESCC | 3.25e-13 | 8.48e-01 | 0.1175 |
498 | ATP5A1 | P44T-E | Human | Esophagus | ESCC | 2.63e-12 | 7.27e-01 | 0.1096 |
498 | ATP5A1 | P47T-E | Human | Esophagus | ESCC | 6.42e-03 | 2.17e-01 | 0.1067 |
498 | ATP5A1 | P48T-E | Human | Esophagus | ESCC | 1.51e-20 | 9.83e-01 | 0.0959 |
498 | ATP5A1 | P49T-E | Human | Esophagus | ESCC | 8.59e-21 | 2.85e+00 | 0.1768 |
498 | ATP5A1 | P52T-E | Human | Esophagus | ESCC | 1.12e-18 | 1.12e+00 | 0.1555 |
498 | ATP5A1 | P54T-E | Human | Esophagus | ESCC | 6.93e-33 | 1.64e+00 | 0.0975 |
498 | ATP5A1 | P56T-E | Human | Esophagus | ESCC | 6.60e-09 | 1.82e+00 | 0.1613 |
498 | ATP5A1 | P57T-E | Human | Esophagus | ESCC | 9.81e-23 | 8.86e-01 | 0.0926 |
498 | ATP5A1 | P62T-E | Human | Esophagus | ESCC | 4.33e-73 | 2.03e+00 | 0.1302 |
498 | ATP5A1 | P65T-E | Human | Esophagus | ESCC | 1.20e-12 | 8.32e-01 | 0.0978 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5A1 | SNV | Missense_Mutation | novel | c.1639N>G | p.Phe547Val | p.F547V | P25705 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5A1 | SNV | Missense_Mutation | c.712G>C | p.Glu238Gln | p.E238Q | P25705 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.719) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ATP5A1 | SNV | Missense_Mutation | novel | c.886N>G | p.Met296Val | p.M296V | P25705 | protein_coding | deleterious_low_confidence(0.03) | benign(0.091) | TCGA-E9-A54Y-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATP5A1 | SNV | Missense_Mutation | novel | c.1540N>T | p.His514Tyr | p.H514Y | P25705 | protein_coding | tolerated_low_confidence(0.29) | benign(0.031) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ATP5A1 | SNV | Missense_Mutation | c.148N>C | p.Glu50Gln | p.E50Q | P25705 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.715) | TCGA-AA-3712-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ATP5A1 | SNV | Missense_Mutation | c.359N>A | p.Gly120Glu | p.G120E | P25705 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.986) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP5A1 | SNV | Missense_Mutation | c.233N>A | p.Gly78Asp | p.G78D | P25705 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ATP5A1 | SNV | Missense_Mutation | rs773771619 | c.965N>A | p.Arg322His | p.R322H | P25705 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.992) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATP5A1 | SNV | Missense_Mutation | rs201477144 | c.1213N>T | p.Arg405Cys | p.R405C | P25705 | protein_coding | deleterious_low_confidence(0.01) | benign(0.274) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ATP5A1 | SNV | Missense_Mutation | c.218G>A | p.Arg73His | p.R73H | P25705 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.859) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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