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Gene: ATP11B |
Gene summary for ATP11B |
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Gene information | Species | Human | Gene symbol | ATP11B | Gene ID | 23200 |
Gene name | ATPase phospholipid transporting 11B (putative) | |
Gene Alias | ATPIF | |
Cytomap | 3q26.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4DKX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23200 | ATP11B | P80T-E | Human | Esophagus | ESCC | 1.10e-16 | 5.71e-01 | 0.155 |
23200 | ATP11B | P82T-E | Human | Esophagus | ESCC | 1.57e-10 | 4.59e-01 | 0.1072 |
23200 | ATP11B | P83T-E | Human | Esophagus | ESCC | 4.62e-23 | 6.41e-01 | 0.1738 |
23200 | ATP11B | P84T-E | Human | Esophagus | ESCC | 6.79e-10 | 3.21e-01 | 0.0933 |
23200 | ATP11B | P89T-E | Human | Esophagus | ESCC | 8.70e-07 | 5.85e-01 | 0.1752 |
23200 | ATP11B | P91T-E | Human | Esophagus | ESCC | 2.79e-08 | 7.32e-01 | 0.1828 |
23200 | ATP11B | P104T-E | Human | Esophagus | ESCC | 7.89e-03 | 4.44e-01 | 0.0931 |
23200 | ATP11B | P107T-E | Human | Esophagus | ESCC | 3.85e-19 | 4.87e-01 | 0.171 |
23200 | ATP11B | P126T-E | Human | Esophagus | ESCC | 9.18e-04 | 9.04e-01 | 0.1125 |
23200 | ATP11B | P127T-E | Human | Esophagus | ESCC | 2.47e-26 | 2.29e-01 | 0.0826 |
23200 | ATP11B | P128T-E | Human | Esophagus | ESCC | 2.40e-08 | 4.52e-01 | 0.1241 |
23200 | ATP11B | P130T-E | Human | Esophagus | ESCC | 8.18e-27 | 6.05e-01 | 0.1676 |
23200 | ATP11B | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.08e-07 | 7.67e-01 | 0.3371 |
23200 | ATP11B | RNA-P17T-P17T-4 | Human | Lung | IAC | 2.87e-06 | 5.13e-01 | 0.343 |
23200 | ATP11B | RNA-P17T-P17T-6 | Human | Lung | IAC | 3.08e-07 | 6.37e-01 | 0.3385 |
23200 | ATP11B | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.49e-05 | 6.12e-01 | 0.3329 |
23200 | ATP11B | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.39e-09 | 4.92e-01 | -0.2116 |
23200 | ATP11B | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.11e-02 | 5.15e-01 | -0.1941 |
23200 | ATP11B | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.69e-03 | 5.43e-01 | -0.2107 |
23200 | ATP11B | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.26e-10 | 7.42e-01 | -0.2119 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:0015914 | Colorectum | FAP | phospholipid transport | 23/2622 | 96/18723 | 6.09e-03 | 3.82e-02 | 23 |
GO:00068692 | Colorectum | CRC | lipid transport | 63/2078 | 398/18723 | 2.36e-03 | 2.26e-02 | 63 |
GO:00108763 | Colorectum | CRC | lipid localization | 68/2078 | 448/18723 | 4.60e-03 | 3.58e-02 | 68 |
GO:00159142 | Lung | IAC | phospholipid transport | 20/2061 | 96/18723 | 3.58e-03 | 3.00e-02 | 20 |
GO:00157482 | Lung | IAC | organophosphate ester transport | 26/2061 | 140/18723 | 5.22e-03 | 3.97e-02 | 26 |
GO:001591411 | Lung | AIS | phospholipid transport | 18/1849 | 96/18723 | 5.64e-03 | 4.76e-02 | 18 |
GO:00157483 | Oral cavity | EOLP | organophosphate ester transport | 28/2218 | 140/18723 | 3.66e-03 | 2.05e-02 | 28 |
GO:001574811 | Oral cavity | NEOLP | organophosphate ester transport | 25/2005 | 140/18723 | 7.16e-03 | 3.63e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP11B | SNV | Missense_Mutation | novel | c.3148N>A | p.Leu1050Ile | p.L1050I | Q9Y2G3 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP11B | SNV | Missense_Mutation | c.538N>A | p.Glu180Lys | p.E180K | Q9Y2G3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A1AO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ATP11B | SNV | Missense_Mutation | rs200531169 | c.2801A>T | p.His934Leu | p.H934L | Q9Y2G3 | protein_coding | tolerated(0.11) | benign(0.009) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP11B | SNV | Missense_Mutation | c.232N>G | p.Gln78Glu | p.Q78E | Q9Y2G3 | protein_coding | deleterious(0.04) | probably_damaging(0.926) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP11B | SNV | Missense_Mutation | c.847N>C | p.Glu283Gln | p.E283Q | Q9Y2G3 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ATP11B | insertion | Frame_Shift_Ins | novel | c.1833_1834insGAGACTGACATTG | p.Lys612GlufsTer12 | p.K612Efs*12 | Q9Y2G3 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ATP11B | SNV | Missense_Mutation | novel | c.1792N>A | p.Glu598Lys | p.E598K | Q9Y2G3 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
ATP11B | SNV | Missense_Mutation | rs760169325 | c.2702N>C | p.Leu901Ser | p.L901S | Q9Y2G3 | protein_coding | tolerated(0.22) | benign(0.071) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
ATP11B | SNV | Missense_Mutation | c.1343N>A | p.Gly448Glu | p.G448E | Q9Y2G3 | protein_coding | deleterious(0.05) | possibly_damaging(0.812) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
ATP11B | SNV | Missense_Mutation | novel | c.917N>A | p.Ile306Asn | p.I306N | Q9Y2G3 | protein_coding | deleterious(0.01) | possibly_damaging(0.908) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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