![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ATF3 |
Gene summary for ATF3 |
![]() |
Gene information | Species | Human | Gene symbol | ATF3 | Gene ID | 467 |
Gene name | activating transcription factor 3 | |
Gene Alias | ATF3 | |
Cytomap | 1q32.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P18847 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
467 | ATF3 | P79T-E | Human | Esophagus | ESCC | 3.80e-38 | 2.88e+00 | 0.1154 |
467 | ATF3 | P80T-E | Human | Esophagus | ESCC | 5.97e-77 | 5.18e+00 | 0.155 |
467 | ATF3 | P82T-E | Human | Esophagus | ESCC | 1.58e-19 | 2.93e+00 | 0.1072 |
467 | ATF3 | P83T-E | Human | Esophagus | ESCC | 4.03e-21 | 1.90e+00 | 0.1738 |
467 | ATF3 | P84T-E | Human | Esophagus | ESCC | 1.43e-16 | 3.31e+00 | 0.0933 |
467 | ATF3 | P89T-E | Human | Esophagus | ESCC | 1.62e-16 | 4.25e+00 | 0.1752 |
467 | ATF3 | P91T-E | Human | Esophagus | ESCC | 3.00e-07 | 2.94e+00 | 0.1828 |
467 | ATF3 | P94T-E | Human | Esophagus | ESCC | 1.07e-11 | 2.25e+00 | 0.0879 |
467 | ATF3 | P104T-E | Human | Esophagus | ESCC | 3.57e-05 | 2.12e+00 | 0.0931 |
467 | ATF3 | P107T-E | Human | Esophagus | ESCC | 3.04e-39 | 3.68e+00 | 0.171 |
467 | ATF3 | P126T-E | Human | Esophagus | ESCC | 2.39e-13 | 2.58e+00 | 0.1125 |
467 | ATF3 | P127T-E | Human | Esophagus | ESCC | 2.89e-59 | 2.52e+00 | 0.0826 |
467 | ATF3 | P128T-E | Human | Esophagus | ESCC | 3.06e-41 | 4.16e+00 | 0.1241 |
467 | ATF3 | P130T-E | Human | Esophagus | ESCC | 4.57e-44 | 3.69e+00 | 0.1676 |
467 | ATF3 | S42 | Human | Liver | HCC | 1.65e-02 | -8.02e-01 | -0.0103 |
467 | ATF3 | S43 | Human | Liver | Cirrhotic | 2.22e-32 | -8.96e-01 | -0.0187 |
467 | ATF3 | HCC1_Meng | Human | Liver | HCC | 2.05e-31 | -7.63e-01 | 0.0246 |
467 | ATF3 | HCC2_Meng | Human | Liver | HCC | 3.47e-07 | -1.01e-01 | 0.0107 |
467 | ATF3 | cirrhotic1 | Human | Liver | Cirrhotic | 2.68e-08 | 5.73e-02 | 0.0202 |
467 | ATF3 | cirrhotic2 | Human | Liver | Cirrhotic | 4.02e-09 | -3.18e-01 | 0.0201 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:00069869 | Breast | Precancer | response to unfolded protein | 28/1080 | 137/18723 | 3.81e-09 | 3.00e-07 | 28 |
GO:00359669 | Breast | Precancer | response to topologically incorrect protein | 29/1080 | 159/18723 | 3.00e-08 | 1.89e-06 | 29 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00346209 | Breast | Precancer | cellular response to unfolded protein | 21/1080 | 96/18723 | 9.80e-08 | 5.46e-06 | 21 |
GO:20012356 | Breast | Precancer | positive regulation of apoptotic signaling pathway | 24/1080 | 126/18723 | 1.98e-07 | 1.01e-05 | 24 |
GO:00359679 | Breast | Precancer | cellular response to topologically incorrect protein | 22/1080 | 116/18723 | 6.84e-07 | 2.80e-05 | 22 |
GO:20012369 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway | 24/1080 | 151/18723 | 5.78e-06 | 1.70e-04 | 24 |
GO:00436209 | Breast | Precancer | regulation of DNA-templated transcription in response to stress | 13/1080 | 53/18723 | 7.06e-06 | 1.95e-04 | 13 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:00436189 | Breast | Precancer | regulation of transcription from RNA polymerase II promoter in response to stress | 12/1080 | 47/18723 | 1.02e-05 | 2.67e-04 | 12 |
GO:00309687 | Breast | Precancer | endoplasmic reticulum unfolded protein response | 15/1080 | 74/18723 | 1.74e-05 | 4.17e-04 | 15 |
GO:00712435 | Breast | Precancer | cellular response to arsenic-containing substance | 7/1080 | 20/18723 | 8.31e-05 | 1.61e-03 | 7 |
GO:00316679 | Breast | Precancer | response to nutrient levels | 47/1080 | 474/18723 | 2.09e-04 | 3.27e-03 | 47 |
GO:00714969 | Breast | Precancer | cellular response to external stimulus | 33/1080 | 320/18723 | 9.01e-04 | 1.03e-02 | 33 |
GO:00060066 | Breast | Precancer | glucose metabolic process | 23/1080 | 196/18723 | 9.54e-04 | 1.07e-02 | 23 |
GO:00316688 | Breast | Precancer | cellular response to extracellular stimulus | 27/1080 | 246/18723 | 1.02e-03 | 1.13e-02 | 27 |
GO:0035914 | Breast | Precancer | skeletal muscle cell differentiation | 11/1080 | 67/18723 | 1.47e-03 | 1.52e-02 | 11 |
GO:00092677 | Breast | Precancer | cellular response to starvation | 19/1080 | 156/18723 | 1.65e-03 | 1.67e-02 | 19 |
GO:19020418 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 9/1080 | 49/18723 | 1.74e-03 | 1.74e-02 | 9 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ATF3 | DUCT1 | Pancreas | PanIN | FOSB,PPP1R15A,SERTAD1, etc. | 2.91e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATF3 | SNV | Missense_Mutation | c.379G>A | p.Glu127Lys | p.E127K | P18847 | protein_coding | deleterious(0.05) | benign(0.247) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
ATF3 | SNV | Missense_Mutation | c.498N>C | p.Glu166Asp | p.E166D | P18847 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-AR-A1AN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
ATF3 | SNV | Missense_Mutation | c.62N>G | p.Pro21Arg | p.P21R | P18847 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATF3 | SNV | Missense_Mutation | novel | c.278G>A | p.Arg93Gln | p.R93Q | P18847 | protein_coding | tolerated(0.08) | possibly_damaging(0.634) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATF3 | SNV | Missense_Mutation | novel | c.455C>T | p.Thr152Met | p.T152M | P18847 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATF3 | SNV | Missense_Mutation | c.377C>T | p.Ala126Val | p.A126V | P18847 | protein_coding | tolerated(0.13) | benign(0.175) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATF3 | SNV | Missense_Mutation | novel | c.278G>A | p.Arg93Gln | p.R93Q | P18847 | protein_coding | tolerated(0.08) | possibly_damaging(0.634) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ATF3 | SNV | Missense_Mutation | novel | c.284G>T | p.Arg95Ile | p.R95I | P18847 | protein_coding | deleterious(0) | possibly_damaging(0.848) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ATF3 | SNV | Missense_Mutation | novel | c.540N>T | p.Gln180His | p.Q180H | P18847 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.867) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATF3 | SNV | Missense_Mutation | c.505C>A | p.Leu169Ile | p.L169I | P18847 | protein_coding | tolerated(0.32) | probably_damaging(0.987) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
467 | ATF3 | TRANSCRIPTION FACTOR | PROGESTERONE | PROGESTERONE | 15674352 |
Page: 1 |