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Gene: AIG1 |
Gene summary for AIG1 |
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Gene information | Species | Human | Gene symbol | AIG1 | Gene ID | 51390 |
Gene name | androgen induced 1 | |
Gene Alias | AIG-1 | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | Q9NVV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51390 | AIG1 | C38 | Human | Oral cavity | OSCC | 4.76e-05 | 1.06e+00 | 0.172 |
51390 | AIG1 | C43 | Human | Oral cavity | OSCC | 1.26e-19 | 4.43e-01 | 0.1704 |
51390 | AIG1 | C46 | Human | Oral cavity | OSCC | 7.91e-10 | 3.90e-01 | 0.1673 |
51390 | AIG1 | C57 | Human | Oral cavity | OSCC | 1.78e-06 | 4.05e-01 | 0.1679 |
51390 | AIG1 | C06 | Human | Oral cavity | OSCC | 3.56e-03 | 9.31e-01 | 0.2699 |
51390 | AIG1 | C08 | Human | Oral cavity | OSCC | 5.47e-43 | 9.73e-01 | 0.1919 |
51390 | AIG1 | C09 | Human | Oral cavity | OSCC | 2.83e-25 | 8.69e-01 | 0.1431 |
51390 | AIG1 | LN46 | Human | Oral cavity | OSCC | 2.86e-04 | 4.12e-01 | 0.1666 |
51390 | AIG1 | SYSMH1 | Human | Oral cavity | OSCC | 3.59e-14 | 4.35e-01 | 0.1127 |
51390 | AIG1 | SYSMH2 | Human | Oral cavity | OSCC | 3.41e-11 | 6.10e-01 | 0.2326 |
51390 | AIG1 | SYSMH3 | Human | Oral cavity | OSCC | 8.10e-27 | 9.00e-01 | 0.2442 |
51390 | AIG1 | SYSMH4 | Human | Oral cavity | OSCC | 9.95e-03 | 2.02e-02 | 0.1226 |
51390 | AIG1 | SYSMH5 | Human | Oral cavity | OSCC | 1.91e-08 | 4.40e-01 | 0.0647 |
51390 | AIG1 | SYSMH6 | Human | Oral cavity | OSCC | 8.46e-12 | 5.51e-01 | 0.1275 |
51390 | AIG1 | HTA12-25-1 | Human | Pancreas | PDAC | 6.67e-04 | 6.15e-01 | 0.313 |
51390 | AIG1 | HTA12-26-1 | Human | Pancreas | PDAC | 6.10e-09 | 6.82e-01 | 0.3728 |
51390 | AIG1 | HTA12-29-1 | Human | Pancreas | PDAC | 4.51e-27 | 7.47e-01 | 0.3722 |
51390 | AIG1 | P1_cSCC | Human | Skin | cSCC | 6.75e-10 | 4.43e-01 | 0.0292 |
51390 | AIG1 | P2_cSCC | Human | Skin | cSCC | 7.99e-05 | 3.23e-01 | -0.024 |
51390 | AIG1 | P4_cSCC | Human | Skin | cSCC | 6.03e-12 | 3.63e-01 | -0.00290000000000005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00090628 | Esophagus | ESCC | fatty acid catabolic process | 66/8552 | 100/18723 | 3.21e-05 | 2.66e-04 | 66 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:00723297 | Esophagus | ESCC | monocarboxylic acid catabolic process | 74/8552 | 122/18723 | 6.03e-04 | 3.27e-03 | 74 |
GO:00442427 | Esophagus | ESCC | cellular lipid catabolic process | 121/8552 | 214/18723 | 8.63e-04 | 4.43e-03 | 121 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00160427 | Esophagus | ESCC | lipid catabolic process | 168/8552 | 320/18723 | 7.97e-03 | 2.84e-02 | 168 |
GO:00463953 | Liver | NAFLD | carboxylic acid catabolic process | 73/1882 | 236/18723 | 4.16e-19 | 1.22e-15 | 73 |
GO:00160544 | Liver | NAFLD | organic acid catabolic process | 73/1882 | 240/18723 | 1.20e-18 | 2.34e-15 | 73 |
GO:00442825 | Liver | NAFLD | small molecule catabolic process | 91/1882 | 376/18723 | 8.96e-16 | 1.31e-12 | 91 |
GO:00066316 | Liver | NAFLD | fatty acid metabolic process | 92/1882 | 390/18723 | 3.38e-15 | 3.29e-12 | 92 |
GO:00723295 | Liver | NAFLD | monocarboxylic acid catabolic process | 39/1882 | 122/18723 | 2.40e-11 | 8.77e-09 | 39 |
GO:00090626 | Liver | NAFLD | fatty acid catabolic process | 34/1882 | 100/18723 | 6.81e-11 | 1.99e-08 | 34 |
GO:00442425 | Liver | NAFLD | cellular lipid catabolic process | 52/1882 | 214/18723 | 1.15e-09 | 2.17e-07 | 52 |
GO:00160426 | Liver | NAFLD | lipid catabolic process | 63/1882 | 320/18723 | 1.35e-07 | 1.02e-05 | 63 |
GO:00016763 | Liver | NAFLD | long-chain fatty acid metabolic process | 23/1882 | 112/18723 | 6.73e-04 | 8.66e-03 | 23 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:004428211 | Liver | Cirrhotic | small molecule catabolic process | 151/4634 | 376/18723 | 2.20e-11 | 1.34e-09 | 151 |
GO:001605411 | Liver | Cirrhotic | organic acid catabolic process | 104/4634 | 240/18723 | 1.91e-10 | 9.53e-09 | 104 |
GO:004639511 | Liver | Cirrhotic | carboxylic acid catabolic process | 102/4634 | 236/18723 | 3.41e-10 | 1.63e-08 | 102 |
GO:007232911 | Liver | Cirrhotic | monocarboxylic acid catabolic process | 56/4634 | 122/18723 | 2.87e-07 | 7.01e-06 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AIG1 | SNV | Missense_Mutation | novel | c.115N>A | p.Trp39Arg | p.W39R | Q9NVV5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR |
AIG1 | SNV | Missense_Mutation | novel | c.125T>G | p.Leu42Arg | p.L42R | Q9NVV5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
AIG1 | SNV | Missense_Mutation | c.178N>G | p.Thr60Ala | p.T60A | Q9NVV5 | protein_coding | tolerated(0.58) | benign(0.053) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
AIG1 | SNV | Missense_Mutation | rs549007002 | c.203N>A | p.Arg68Gln | p.R68Q | Q9NVV5 | protein_coding | tolerated(0.24) | benign(0.039) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AIG1 | SNV | Missense_Mutation | novel | c.342N>T | p.Glu114Asp | p.E114D | Q9NVV5 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AIG1 | SNV | Missense_Mutation | c.554A>G | p.Tyr185Cys | p.Y185C | Q9NVV5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AIG1 | SNV | Missense_Mutation | novel | c.74N>G | p.Lys25Arg | p.K25R | Q9NVV5 | protein_coding | tolerated(0.26) | benign(0.011) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
AIG1 | SNV | Missense_Mutation | novel | c.502N>T | p.Gly168Cys | p.G168C | Q9NVV5 | protein_coding | tolerated(0.17) | benign(0.037) | TCGA-BG-A0VW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AIG1 | SNV | Missense_Mutation | rs201448093 | c.430N>A | p.Glu144Lys | p.E144K | Q9NVV5 | protein_coding | deleterious(0.03) | probably_damaging(0.926) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AIG1 | SNV | Missense_Mutation | novel | c.70N>C | p.Tyr24His | p.Y24H | Q9NVV5 | protein_coding | tolerated(0.14) | possibly_damaging(0.864) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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