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Gene: ACTR1B |
Gene summary for ACTR1B |
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Gene information | Species | Human | Gene symbol | ACTR1B | Gene ID | 10120 |
Gene name | actin related protein 1B | |
Gene Alias | ARP1B | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P42025 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10120 | ACTR1B | PTC06 | Human | Thyroid | PTC | 2.36e-20 | 3.94e-01 | 0.2057 |
10120 | ACTR1B | PTC07 | Human | Thyroid | PTC | 7.04e-18 | 3.99e-01 | 0.2044 |
10120 | ACTR1B | ATC09 | Human | Thyroid | ATC | 1.77e-04 | 1.91e-01 | 0.2871 |
10120 | ACTR1B | ATC12 | Human | Thyroid | ATC | 1.74e-12 | 1.67e-01 | 0.34 |
10120 | ACTR1B | ATC13 | Human | Thyroid | ATC | 1.49e-14 | 1.83e-01 | 0.34 |
10120 | ACTR1B | ATC1 | Human | Thyroid | ATC | 1.82e-06 | 2.78e-01 | 0.2878 |
10120 | ACTR1B | ATC2 | Human | Thyroid | ATC | 1.71e-05 | 3.61e-01 | 0.34 |
10120 | ACTR1B | ATC3 | Human | Thyroid | ATC | 2.19e-02 | 2.97e-01 | 0.338 |
10120 | ACTR1B | ATC4 | Human | Thyroid | ATC | 2.54e-14 | 2.22e-01 | 0.34 |
10120 | ACTR1B | ATC5 | Human | Thyroid | ATC | 9.97e-12 | 1.97e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501614 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502214 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0513222 | Liver | Cirrhotic | Salmonella infection | 121/2530 | 249/8465 | 2.47e-10 | 5.13e-09 | 3.16e-09 | 121 |
hsa0501615 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502215 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0513232 | Liver | Cirrhotic | Salmonella infection | 121/2530 | 249/8465 | 2.47e-10 | 5.13e-09 | 3.16e-09 | 121 |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTR1B | SNV | Missense_Mutation | novel | c.651N>G | p.Ile217Met | p.I217M | P42025 | protein_coding | tolerated(0.1) | benign(0.383) | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ACTR1B | SNV | Missense_Mutation | c.947N>A | p.Ser316Asn | p.S316N | P42025 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ACTR1B | insertion | Frame_Shift_Ins | novel | c.253_254insCC | p.Asp85AlafsTer75 | p.D85Afs*75 | P42025 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ACTR1B | insertion | Nonsense_Mutation | novel | c.251_252insGGGATGGGGCCCTCAGGAGGGGTAGGAGGCTGAGCTGCCTGTG | p.Asn84LysfsTer9 | p.N84Kfs*9 | P42025 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ACTR1B | deletion | Frame_Shift_Del | novel | c.716delT | p.Val239GlyfsTer80 | p.V239Gfs*80 | P42025 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ACTR1B | SNV | Missense_Mutation | rs559419020 | c.1106N>A | p.Arg369His | p.R369H | P42025 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACTR1B | SNV | Missense_Mutation | c.662C>T | p.Ala221Val | p.A221V | P42025 | protein_coding | tolerated(0.16) | benign(0.009) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ACTR1B | SNV | Missense_Mutation | novel | c.815N>C | p.Ser272Thr | p.S272T | P42025 | protein_coding | tolerated(0.35) | benign(0) | TCGA-AA-3673-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACTR1B | SNV | Missense_Mutation | c.199N>T | p.Gly67Trp | p.G67W | P42025 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ACTR1B | SNV | Missense_Mutation | rs372634354 | c.263N>A | p.Arg88His | p.R88H | P42025 | protein_coding | tolerated(0.09) | benign(0.027) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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