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Gene: ZNF704 |
Gene summary for ZNF704 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF704 | Gene ID | 619279 |
| Gene name | zinc finger protein 704 | |
| Gene Alias | Gig1 | |
| Cytomap | 8q21.13 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZNC4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 619279 | ZNF704 | 048752_1579-all-cells | Human | Prostate | BPH | 2.77e-35 | 6.65e-01 | 0.1008 |
| 619279 | ZNF704 | 052095_1628-all-cells | Human | Prostate | BPH | 8.68e-29 | 6.39e-01 | 0.1032 |
| 619279 | ZNF704 | 052097_1595-all-cells | Human | Prostate | BPH | 1.61e-17 | 5.14e-01 | 0.0972 |
| 619279 | ZNF704 | 052099_1652-all-cells | Human | Prostate | BPH | 2.24e-31 | 7.68e-01 | 0.1038 |
| 619279 | ZNF704 | Dong_P1 | Human | Prostate | Tumor | 1.92e-12 | 6.29e-02 | 0.035 |
| 619279 | ZNF704 | Dong_P3 | Human | Prostate | Tumor | 1.40e-20 | 4.03e-01 | 0.0278 |
| 619279 | ZNF704 | Dong_P4 | Human | Prostate | Tumor | 4.42e-06 | 2.56e-01 | 0.0292 |
| 619279 | ZNF704 | Dong_P5 | Human | Prostate | Tumor | 2.02e-10 | 7.90e-03 | 0.053 |
| 619279 | ZNF704 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 1.10e-04 | 6.50e-01 | 0.1557 |
| 619279 | ZNF704 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 3.47e-16 | 7.61e-01 | 0.1633 |
| 619279 | ZNF704 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 2.61e-20 | 8.15e-01 | 0.1608 |
| 619279 | ZNF704 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 5.84e-12 | 7.21e-01 | 0.1604 |
| 619279 | ZNF704 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.89e-09 | 5.94e-01 | 0.1621 |
| 619279 | ZNF704 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 5.58e-12 | 8.98e-01 | 0.1619 |
| 619279 | ZNF704 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.26e-03 | 6.40e-01 | 0.159 |
| 619279 | ZNF704 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 2.29e-09 | 6.11e-01 | 0.1602 |
| 619279 | ZNF704 | GSM5353232_PA_PR5249_T1_S3_L001 | Human | Prostate | Tumor | 1.15e-03 | 6.10e-01 | 0.1439 |
| 619279 | ZNF704 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 1.42e-02 | 4.50e-01 | 0.1608 |
| 619279 | ZNF704 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 2.82e-07 | 7.96e-01 | 0.1622 |
| 619279 | ZNF704 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 2.48e-06 | 3.94e-01 | 0.1575 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF704 | MAST | Pancreas | Healthy | FER,AGAP1,SLC24A3, etc. | 7.79e-02 |  |
| ZNF704 | MAST | Prostate | Healthy | IL18R1,SLC24A3,NUTM2A-AS1, etc. | 3.76e-01 |  |
| ZNF704 | MAST | Skin | ADJ | GATA2,LTC4S,TPSAB1, etc. | 3.29e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF704 | SNV | Missense_Mutation | rs752885224 | c.1157G>A | p.Arg386Gln | p.R386Q | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| ZNF704 | SNV | Missense_Mutation | novel | c.119N>T | p.Ala40Val | p.A40V | Q6ZNC4 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF704 | insertion | Nonsense_Mutation | novel | c.733_734insAAATAAAATGTAAGCATTGGAAAGCTTTGGCA | p.Ser245Ter | p.S245* | Q6ZNC4 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
| ZNF704 | SNV | Missense_Mutation | c.1063N>A | p.Gly355Arg | p.G355R | Q6ZNC4 | protein_coding | tolerated(0.28) | probably_damaging(0.911) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF704 | SNV | Missense_Mutation | c.824N>A | p.Arg275Gln | p.R275Q | Q6ZNC4 | protein_coding | tolerated(0.34) | benign(0.014) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ZNF704 | SNV | Missense_Mutation | c.1040N>T | p.Pro347Leu | p.P347L | Q6ZNC4 | protein_coding | tolerated(0.14) | probably_damaging(0.998) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| ZNF704 | SNV | Missense_Mutation | novel | c.46N>C | p.Lys16Gln | p.K16Q | Q6ZNC4 | protein_coding | tolerated_low_confidence(0.52) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| ZNF704 | SNV | Missense_Mutation | rs139476385 | c.1052C>T | p.Pro351Leu | p.P351L | Q6ZNC4 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-CM-6161-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF704 | SNV | Missense_Mutation | rs752885224 | c.1157G>A | p.Arg386Gln | p.R386Q | Q6ZNC4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ZNF704 | SNV | Missense_Mutation | c.980N>A | p.Ser327Asn | p.S327N | Q6ZNC4 | protein_coding | tolerated(0.58) | benign(0.003) | TCGA-G4-6294-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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