Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZCCHC7

Gene summary for ZCCHC7

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZCCHC7

Gene ID

84186

Gene namezinc finger CCHC-type containing 7
Gene AliasAIR1
Cytomap9p13.2
Gene Typeprotein-coding
GO ID

GO:0005575

UniProtAcc

Q05DN1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84186ZCCHC7P5T-EHumanEsophagusESCC1.47e-142.35e-010.1327
84186ZCCHC7P8T-EHumanEsophagusESCC9.00e-122.44e-010.0889
84186ZCCHC7P9T-EHumanEsophagusESCC1.03e-214.74e-010.1131
84186ZCCHC7P10T-EHumanEsophagusESCC8.93e-264.20e-010.116
84186ZCCHC7P11T-EHumanEsophagusESCC1.32e-145.61e-010.1426
84186ZCCHC7P12T-EHumanEsophagusESCC1.86e-224.76e-010.1122
84186ZCCHC7P15T-EHumanEsophagusESCC8.84e-204.06e-010.1149
84186ZCCHC7P16T-EHumanEsophagusESCC9.07e-184.27e-010.1153
84186ZCCHC7P17T-EHumanEsophagusESCC1.00e-164.88e-010.1278
84186ZCCHC7P19T-EHumanEsophagusESCC3.30e-063.88e-010.1662
84186ZCCHC7P20T-EHumanEsophagusESCC8.60e-224.21e-010.1124
84186ZCCHC7P21T-EHumanEsophagusESCC3.45e-233.85e-010.1617
84186ZCCHC7P22T-EHumanEsophagusESCC7.23e-172.89e-010.1236
84186ZCCHC7P23T-EHumanEsophagusESCC3.25e-286.10e-010.108
84186ZCCHC7P24T-EHumanEsophagusESCC1.25e-204.71e-010.1287
84186ZCCHC7P26T-EHumanEsophagusESCC1.35e-274.97e-010.1276
84186ZCCHC7P27T-EHumanEsophagusESCC2.36e-183.19e-010.1055
84186ZCCHC7P28T-EHumanEsophagusESCC4.20e-851.36e+000.1149
84186ZCCHC7P30T-EHumanEsophagusESCC6.00e-133.21e-010.137
84186ZCCHC7P31T-EHumanEsophagusESCC4.70e-162.13e-010.1251
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa030187EndometriumEECRNA degradation20/123779/84658.36e-033.88e-022.89e-0220
hsa0301812EndometriumEECRNA degradation20/123779/84658.36e-033.88e-022.89e-0220
hsa0301810EsophagusHGINRNA degradation27/138379/84657.73e-059.00e-047.15e-0427
hsa0301815EsophagusHGINRNA degradation27/138379/84657.73e-059.00e-047.15e-0427
hsa0301824EsophagusESCCRNA degradation62/420579/84651.18e-079.39e-074.81e-0762
hsa0301834EsophagusESCCRNA degradation62/420579/84651.18e-079.39e-074.81e-0762
hsa03018LiverCirrhoticRNA degradation44/253079/84651.43e-061.65e-051.02e-0544
hsa030181LiverCirrhoticRNA degradation44/253079/84651.43e-061.65e-051.02e-0544
hsa030182LiverHCCRNA degradation58/402079/84652.29e-062.19e-051.22e-0558
hsa030183LiverHCCRNA degradation58/402079/84652.29e-062.19e-051.22e-0558
hsa030189Oral cavityOSCCRNA degradation59/370479/84652.05e-081.91e-079.70e-0859
hsa0301814Oral cavityOSCCRNA degradation59/370479/84652.05e-081.91e-079.70e-0859
hsa0301841Oral cavityEOLPRNA degradation22/121879/84651.33e-034.80e-032.83e-0322
hsa0301851Oral cavityEOLPRNA degradation22/121879/84651.33e-034.80e-032.83e-0322
hsa0301861Oral cavityNEOLPRNA degradation18/111279/84651.25e-024.06e-022.56e-0218
hsa0301871Oral cavityNEOLPRNA degradation18/111279/84651.25e-024.06e-022.56e-0218
hsa030188ProstateBPHRNA degradation29/171879/84655.17e-042.67e-031.65e-0329
hsa0301813ProstateBPHRNA degradation29/171879/84655.17e-042.67e-031.65e-0329
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZCCHC7SNVMissense_Mutationnovelc.1082N>Tp.His361Leup.H361LQ8N3Z6protein_codingdeleterious(0.03)benign(0.115)TCGA-A7-A3RF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozolePD
ZCCHC7SNVMissense_Mutationrs542717674c.787N>Tp.Arg263Cysp.R263CQ8N3Z6protein_codingdeleterious(0.04)probably_damaging(0.926)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZCCHC7SNVMissense_Mutationrs749439929c.37N>Ap.Glu13Lysp.E13KQ8N3Z6protein_codingdeleterious(0.04)probably_damaging(0.994)TCGA-AN-A0FS-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZCCHC7SNVMissense_Mutationc.1175N>Gp.Lys392Argp.K392RQ8N3Z6protein_codingtolerated(0.47)benign(0)TCGA-E2-A15D-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
ZCCHC7SNVMissense_Mutationnovelc.952G>Ap.Ala318Thrp.A318TQ8N3Z6protein_codingtolerated(0.06)possibly_damaging(0.481)TCGA-C5-A8XK-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
ZCCHC7SNVMissense_Mutationnovelc.608N>Gp.Glu203Glyp.E203GQ8N3Z6protein_codingdeleterious(0.02)benign(0.009)TCGA-A6-6649-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapyfluorouracilSD
ZCCHC7SNVMissense_Mutationrs761303878c.674N>Ap.Arg225Glnp.R225QQ8N3Z6protein_codingtolerated(0.34)possibly_damaging(0.743)TCGA-AA-3710-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
ZCCHC7SNVMissense_Mutationnovelc.19G>Ap.Glu7Lysp.E7KQ8N3Z6protein_codingdeleterious(0.01)possibly_damaging(0.877)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
ZCCHC7SNVMissense_Mutationc.130G>Tp.Asp44Tyrp.D44YQ8N3Z6protein_codingdeleterious(0.01)possibly_damaging(0.817)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
ZCCHC7SNVMissense_Mutationrs542717674c.787N>Tp.Arg263Cysp.R263CQ8N3Z6protein_codingdeleterious(0.04)probably_damaging(0.926)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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