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Gene: WWTR1 |
Gene summary for WWTR1 |
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Gene information | Species | Human | Gene symbol | WWTR1 | Gene ID | 25937 |
Gene name | WW domain containing transcription regulator 1 | |
Gene Alias | TAZ | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9GZV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25937 | WWTR1 | P80T-E | Human | Esophagus | ESCC | 1.59e-06 | 5.86e-01 | 0.155 |
25937 | WWTR1 | P83T-E | Human | Esophagus | ESCC | 2.50e-30 | 1.54e+00 | 0.1738 |
25937 | WWTR1 | P84T-E | Human | Esophagus | ESCC | 3.42e-08 | 1.03e+00 | 0.0933 |
25937 | WWTR1 | P89T-E | Human | Esophagus | ESCC | 1.24e-03 | 9.18e-01 | 0.1752 |
25937 | WWTR1 | P107T-E | Human | Esophagus | ESCC | 8.53e-22 | 7.48e-01 | 0.171 |
25937 | WWTR1 | P127T-E | Human | Esophagus | ESCC | 2.74e-07 | 4.57e-01 | 0.0826 |
25937 | WWTR1 | P128T-E | Human | Esophagus | ESCC | 9.14e-04 | 3.05e-01 | 0.1241 |
25937 | WWTR1 | P130T-E | Human | Esophagus | ESCC | 1.63e-08 | 3.16e-01 | 0.1676 |
25937 | WWTR1 | S43 | Human | Liver | Cirrhotic | 2.33e-14 | -3.28e-01 | -0.0187 |
25937 | WWTR1 | HCC1_Meng | Human | Liver | HCC | 1.06e-23 | -5.59e-01 | 0.0246 |
25937 | WWTR1 | HCC2_Meng | Human | Liver | HCC | 2.52e-29 | 3.92e-01 | 0.0107 |
25937 | WWTR1 | cirrhotic1 | Human | Liver | Cirrhotic | 1.09e-08 | 7.83e-02 | 0.0202 |
25937 | WWTR1 | cirrhotic2 | Human | Liver | Cirrhotic | 1.14e-09 | 1.04e-01 | 0.0201 |
25937 | WWTR1 | cirrhotic3 | Human | Liver | Cirrhotic | 5.83e-07 | -8.96e-02 | 0.0215 |
25937 | WWTR1 | HCC1 | Human | Liver | HCC | 7.87e-04 | 3.14e+00 | 0.5336 |
25937 | WWTR1 | HCC5 | Human | Liver | HCC | 1.14e-05 | 6.00e-01 | 0.4932 |
25937 | WWTR1 | Pt13.a | Human | Liver | HCC | 1.21e-11 | -5.26e-01 | 0.021 |
25937 | WWTR1 | Pt13.b | Human | Liver | HCC | 7.83e-05 | -4.34e-01 | 0.0251 |
25937 | WWTR1 | Pt13.c | Human | Liver | HCC | 2.37e-09 | -5.77e-01 | 0.0076 |
25937 | WWTR1 | Pt14.d | Human | Liver | HCC | 1.40e-04 | -4.27e-01 | 0.0143 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
GO:000646910 | Cervix | CC | negative regulation of protein kinase activity | 47/2311 | 212/18723 | 4.13e-05 | 6.36e-04 | 47 |
GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:00308563 | Cervix | CC | regulation of epithelial cell differentiation | 36/2311 | 154/18723 | 1.02e-04 | 1.31e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0439014 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0439023 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa0439033 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa043907 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa0439012 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa0439022 | Lung | AIS | Hippo signaling pathway | 34/961 | 157/8465 | 1.36e-04 | 1.63e-03 | 1.05e-03 | 34 |
hsa0439032 | Lung | AIS | Hippo signaling pathway | 34/961 | 157/8465 | 1.36e-04 | 1.63e-03 | 1.05e-03 | 34 |
hsa0439041 | Lung | MIAC | Hippo signaling pathway | 21/507 | 157/8465 | 4.20e-04 | 7.19e-03 | 5.20e-03 | 21 |
hsa0439051 | Lung | MIAC | Hippo signaling pathway | 21/507 | 157/8465 | 4.20e-04 | 7.19e-03 | 5.20e-03 | 21 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WWTR1 | SNV | Missense_Mutation | c.32C>T | p.Pro11Leu | p.P11L | Q9GZV5 | protein_coding | deleterious(0) | benign(0.007) | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
WWTR1 | SNV | Missense_Mutation | rs756242761 | c.235N>T | p.Ala79Ser | p.A79S | Q9GZV5 | protein_coding | tolerated(0.47) | benign(0.038) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WWTR1 | deletion | Frame_Shift_Del | novel | c.666delN | p.Asn223MetfsTer3 | p.N223Mfs*3 | Q9GZV5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
WWTR1 | SNV | Missense_Mutation | novel | c.1125N>T | p.Glu375Asp | p.E375D | Q9GZV5 | protein_coding | deleterious(0.02) | benign(0.124) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WWTR1 | SNV | Missense_Mutation | c.872N>C | p.Ile291Thr | p.I291T | Q9GZV5 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WWTR1 | SNV | Missense_Mutation | c.14N>T | p.Ser5Leu | p.S5L | Q9GZV5 | protein_coding | deleterious_low_confidence(0.01) | benign(0.028) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WWTR1 | deletion | Frame_Shift_Del | c.603delC | p.Ser202ValfsTer3 | p.S202Vfs*3 | Q9GZV5 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
WWTR1 | SNV | Missense_Mutation | novel | c.910N>A | p.Pro304Thr | p.P304T | Q9GZV5 | protein_coding | tolerated(1) | benign(0.006) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
WWTR1 | SNV | Missense_Mutation | rs766572084 | c.671C>T | p.Ala224Val | p.A224V | Q9GZV5 | protein_coding | tolerated(0.08) | benign(0.23) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
WWTR1 | SNV | Missense_Mutation | novel | c.364G>A | p.Asp122Asn | p.D122N | Q9GZV5 | protein_coding | deleterious(0) | benign(0.169) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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