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Gene: WIPF2 |
Gene summary for WIPF2 |
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Gene information | Species | Human | Gene symbol | WIPF2 | Gene ID | 147179 |
Gene name | WAS/WASL interacting protein family member 2 | |
Gene Alias | WICH | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q8TF74 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147179 | WIPF2 | P40T-E | Human | Esophagus | ESCC | 3.12e-15 | 2.66e-01 | 0.109 |
147179 | WIPF2 | P42T-E | Human | Esophagus | ESCC | 9.10e-11 | 2.33e-01 | 0.1175 |
147179 | WIPF2 | P44T-E | Human | Esophagus | ESCC | 5.59e-10 | 1.76e-01 | 0.1096 |
147179 | WIPF2 | P47T-E | Human | Esophagus | ESCC | 3.26e-16 | 3.07e-01 | 0.1067 |
147179 | WIPF2 | P48T-E | Human | Esophagus | ESCC | 8.18e-16 | 2.74e-01 | 0.0959 |
147179 | WIPF2 | P49T-E | Human | Esophagus | ESCC | 1.61e-09 | 8.63e-01 | 0.1768 |
147179 | WIPF2 | P52T-E | Human | Esophagus | ESCC | 1.32e-19 | 2.76e-01 | 0.1555 |
147179 | WIPF2 | P54T-E | Human | Esophagus | ESCC | 3.32e-15 | 3.14e-01 | 0.0975 |
147179 | WIPF2 | P56T-E | Human | Esophagus | ESCC | 8.34e-04 | 7.70e-01 | 0.1613 |
147179 | WIPF2 | P57T-E | Human | Esophagus | ESCC | 6.50e-12 | 1.19e-01 | 0.0926 |
147179 | WIPF2 | P61T-E | Human | Esophagus | ESCC | 1.06e-12 | 3.36e-01 | 0.099 |
147179 | WIPF2 | P62T-E | Human | Esophagus | ESCC | 1.55e-39 | 7.14e-01 | 0.1302 |
147179 | WIPF2 | P65T-E | Human | Esophagus | ESCC | 1.23e-18 | 3.04e-01 | 0.0978 |
147179 | WIPF2 | P74T-E | Human | Esophagus | ESCC | 1.69e-45 | 1.29e+00 | 0.1479 |
147179 | WIPF2 | P75T-E | Human | Esophagus | ESCC | 5.64e-19 | 3.73e-01 | 0.1125 |
147179 | WIPF2 | P76T-E | Human | Esophagus | ESCC | 1.71e-15 | 1.83e-01 | 0.1207 |
147179 | WIPF2 | P79T-E | Human | Esophagus | ESCC | 2.09e-18 | 3.23e-01 | 0.1154 |
147179 | WIPF2 | P80T-E | Human | Esophagus | ESCC | 9.40e-37 | 9.38e-01 | 0.155 |
147179 | WIPF2 | P82T-E | Human | Esophagus | ESCC | 6.00e-16 | 5.97e-01 | 0.1072 |
147179 | WIPF2 | P83T-E | Human | Esophagus | ESCC | 1.21e-26 | 5.53e-01 | 0.1738 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030048 | Colorectum | AD | actin filament-based movement | 44/3918 | 127/18723 | 2.31e-04 | 2.99e-03 | 44 |
GO:00300481 | Colorectum | SER | actin filament-based movement | 38/2897 | 127/18723 | 2.80e-05 | 7.56e-04 | 38 |
GO:00300482 | Colorectum | MSS | actin filament-based movement | 44/3467 | 127/18723 | 1.11e-05 | 2.64e-04 | 44 |
GO:00300483 | Colorectum | FAP | actin filament-based movement | 44/2622 | 127/18723 | 3.48e-09 | 5.93e-07 | 44 |
GO:00300484 | Colorectum | CRC | actin filament-based movement | 42/2078 | 127/18723 | 2.96e-11 | 1.97e-08 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513024 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513034 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513043 | Breast | DCIS | Pathogenic Escherichia coli infection | 42/846 | 197/8465 | 1.40e-06 | 2.15e-05 | 1.59e-05 | 42 |
hsa0414416 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0513053 | Breast | DCIS | Pathogenic Escherichia coli infection | 42/846 | 197/8465 | 1.40e-06 | 2.15e-05 | 1.59e-05 | 42 |
hsa0414417 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa051302 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa051352 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa051303 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa051353 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa051304 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WIPF2 | SNV | Missense_Mutation | c.49C>T | p.Pro17Ser | p.P17S | Q8TF74 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.994) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WIPF2 | insertion | In_Frame_Ins | novel | c.142_143insTCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATT | p.Thr48delinsIleSerAlaHisCysAsnLeuHisLeuLeuGlySerSerAspSer | p.T48delinsISAHCNLHLLGSSDS | Q8TF74 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
WIPF2 | deletion | Frame_Shift_Del | novel | c.1269delC | p.Ser423ArgfsTer44 | p.S423Rfs*44 | Q8TF74 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
WIPF2 | SNV | Missense_Mutation | c.845N>A | p.Ser282Tyr | p.S282Y | Q8TF74 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
WIPF2 | SNV | Missense_Mutation | novel | c.519N>A | p.Ser173Arg | p.S173R | Q8TF74 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WIPF2 | SNV | Missense_Mutation | c.238N>T | p.Ala80Ser | p.A80S | Q8TF74 | protein_coding | tolerated(0.41) | benign(0.029) | TCGA-AZ-4616-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | |
WIPF2 | SNV | Missense_Mutation | c.998G>A | p.Arg333Gln | p.R333Q | Q8TF74 | protein_coding | deleterious(0.03) | probably_damaging(0.953) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
WIPF2 | SNV | Missense_Mutation | c.1220A>G | p.Asp407Gly | p.D407G | Q8TF74 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-5341-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
WIPF2 | deletion | Frame_Shift_Del | c.613_616delNNNN | p.Glu206AsnfsTer31 | p.E206Nfs*31 | Q8TF74 | protein_coding | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WIPF2 | deletion | Frame_Shift_Del | c.25delN | p.Pro10HisfsTer20 | p.P10Hfs*20 | Q8TF74 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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