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Gene: WDR83OS |
Gene summary for WDR83OS |
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Gene information | Species | Human | Gene symbol | WDR83OS | Gene ID | 51398 |
Gene name | WD repeat domain 83 opposite strand | |
Gene Alias | ASTERIX | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q9Y284 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51398 | WDR83OS | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.05e-26 | 8.15e-01 | 0.2585 |
51398 | WDR83OS | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.28e-38 | 6.68e-01 | 0.3005 |
51398 | WDR83OS | AEH-subject1 | Human | Endometrium | AEH | 3.00e-11 | -3.20e-01 | -0.3059 |
51398 | WDR83OS | AEH-subject2 | Human | Endometrium | AEH | 1.24e-10 | -3.80e-01 | -0.2525 |
51398 | WDR83OS | AEH-subject3 | Human | Endometrium | AEH | 1.49e-16 | -4.24e-01 | -0.2576 |
51398 | WDR83OS | AEH-subject4 | Human | Endometrium | AEH | 1.50e-16 | -4.83e-01 | -0.2657 |
51398 | WDR83OS | AEH-subject5 | Human | Endometrium | AEH | 2.27e-17 | -4.43e-01 | -0.2953 |
51398 | WDR83OS | EEC-subject1 | Human | Endometrium | EEC | 1.23e-31 | -5.43e-01 | -0.2682 |
51398 | WDR83OS | EEC-subject2 | Human | Endometrium | EEC | 2.37e-18 | -5.04e-01 | -0.2607 |
51398 | WDR83OS | EEC-subject3 | Human | Endometrium | EEC | 6.82e-55 | -6.22e-01 | -0.2525 |
51398 | WDR83OS | EEC-subject4 | Human | Endometrium | EEC | 1.66e-10 | -2.77e-01 | -0.2571 |
51398 | WDR83OS | EEC-subject5 | Human | Endometrium | EEC | 6.44e-16 | -4.38e-01 | -0.249 |
51398 | WDR83OS | GSM5276934 | Human | Endometrium | EEC | 4.01e-02 | -2.46e-01 | -0.0913 |
51398 | WDR83OS | GSM5276937 | Human | Endometrium | EEC | 3.83e-04 | -3.07e-01 | -0.0897 |
51398 | WDR83OS | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.47e-60 | -9.64e-01 | -0.1869 |
51398 | WDR83OS | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 8.60e-55 | -9.64e-01 | -0.1875 |
51398 | WDR83OS | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.13e-62 | -9.64e-01 | -0.1883 |
51398 | WDR83OS | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.16e-83 | -9.64e-01 | -0.1934 |
51398 | WDR83OS | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.16e-83 | -9.64e-01 | -0.1917 |
51398 | WDR83OS | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.64e-78 | -9.64e-01 | -0.1916 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:000645713 | Breast | IDC | protein folding | 47/1434 | 212/18723 | 2.31e-11 | 3.86e-09 | 47 |
GO:000645723 | Breast | DCIS | protein folding | 47/1390 | 212/18723 | 7.84e-12 | 1.53e-09 | 47 |
GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
GO:00064579 | Cervix | CC | protein folding | 44/2311 | 212/18723 | 3.43e-04 | 3.59e-03 | 44 |
GO:000645714 | Cervix | HSIL_HPV | protein folding | 20/737 | 212/18723 | 2.81e-04 | 4.69e-03 | 20 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:0051205 | Colorectum | AD | protein insertion into membrane | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0007029 | Colorectum | AD | endoplasmic reticulum organization | 31/3918 | 87/18723 | 1.08e-03 | 1.00e-02 | 31 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00064571 | Colorectum | SER | protein folding | 54/2897 | 212/18723 | 1.04e-04 | 2.18e-03 | 54 |
GO:00512051 | Colorectum | SER | protein insertion into membrane | 19/2897 | 57/18723 | 6.32e-04 | 8.58e-03 | 19 |
GO:00070291 | Colorectum | SER | endoplasmic reticulum organization | 23/2897 | 87/18723 | 5.77e-03 | 4.23e-02 | 23 |
GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
GO:00064572 | Colorectum | MSS | protein folding | 71/3467 | 212/18723 | 1.25e-07 | 5.91e-06 | 71 |
GO:00512052 | Colorectum | MSS | protein insertion into membrane | 21/3467 | 57/18723 | 8.53e-04 | 8.75e-03 | 21 |
GO:00064573 | Colorectum | MSI-H | protein folding | 33/1319 | 212/18723 | 1.40e-05 | 6.29e-04 | 33 |
GO:00901503 | Colorectum | MSI-H | establishment of protein localization to membrane | 32/1319 | 260/18723 | 1.47e-03 | 2.23e-02 | 32 |
GO:000645710 | Endometrium | AEH | protein folding | 61/2100 | 212/18723 | 1.86e-12 | 3.48e-10 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR83OS | SNV | Missense_Mutation | c.290N>C | p.Gln97Pro | p.Q97P | Q9Y284 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-BH-A0BP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR83OS | SNV | Missense_Mutation | c.20N>G | p.Ser7Trp | p.S7W | Q9Y284 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR83OS | SNV | Missense_Mutation | novel | c.91G>A | p.Asp31Asn | p.D31N | Q9Y284 | protein_coding | tolerated(0.06) | possibly_damaging(0.467) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WDR83OS | SNV | Missense_Mutation | novel | c.212N>T | p.Ser71Phe | p.S71F | Q9Y284 | protein_coding | deleterious(0.03) | probably_damaging(0.917) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR83OS | SNV | Missense_Mutation | novel | c.146T>C | p.Leu49Pro | p.L49P | Q9Y284 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
WDR83OS | SNV | Missense_Mutation | novel | c.166N>G | p.Cys56Gly | p.C56G | Q9Y284 | protein_coding | deleterious(0.03) | possibly_damaging(0.486) | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR83OS | SNV | Missense_Mutation | rs375244334 | c.308N>T | p.Thr103Met | p.T103M | Q9Y284 | protein_coding | tolerated(0.09) | possibly_damaging(0.696) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR83OS | SNV | Missense_Mutation | c.34C>T | p.Pro12Ser | p.P12S | Q9Y284 | protein_coding | tolerated(0.11) | benign(0.011) | TCGA-B5-A0JS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR83OS | SNV | Missense_Mutation | c.240N>T | p.Met80Ile | p.M80I | Q9Y284 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR83OS | SNV | Missense_Mutation | c.119T>A | p.Leu40Gln | p.L40Q | Q9Y284 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-NJ-A55O-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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