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Gene: WDR74 |
Gene summary for WDR74 |
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Gene information | Species | Human | Gene symbol | WDR74 | Gene ID | 54663 |
Gene name | WD repeat domain 74 | |
Gene Alias | Nsa1 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q6RFH5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54663 | WDR74 | C04 | Human | Oral cavity | OSCC | 2.27e-19 | 1.37e+00 | 0.2633 |
54663 | WDR74 | C21 | Human | Oral cavity | OSCC | 4.27e-33 | 1.40e+00 | 0.2678 |
54663 | WDR74 | C30 | Human | Oral cavity | OSCC | 2.33e-33 | 1.95e+00 | 0.3055 |
54663 | WDR74 | C43 | Human | Oral cavity | OSCC | 1.14e-36 | 8.16e-01 | 0.1704 |
54663 | WDR74 | C46 | Human | Oral cavity | OSCC | 1.48e-19 | 6.77e-01 | 0.1673 |
54663 | WDR74 | C51 | Human | Oral cavity | OSCC | 4.65e-06 | 6.49e-01 | 0.2674 |
54663 | WDR74 | C57 | Human | Oral cavity | OSCC | 3.40e-05 | 5.33e-01 | 0.1679 |
54663 | WDR74 | C06 | Human | Oral cavity | OSCC | 4.70e-04 | 9.67e-01 | 0.2699 |
54663 | WDR74 | C08 | Human | Oral cavity | OSCC | 3.54e-39 | 9.34e-01 | 0.1919 |
54663 | WDR74 | C09 | Human | Oral cavity | OSCC | 1.43e-10 | 5.59e-01 | 0.1431 |
54663 | WDR74 | LN22 | Human | Oral cavity | OSCC | 2.68e-08 | 1.28e+00 | 0.1733 |
54663 | WDR74 | LN38 | Human | Oral cavity | OSCC | 2.34e-04 | 1.02e+00 | 0.168 |
54663 | WDR74 | LN46 | Human | Oral cavity | OSCC | 1.73e-09 | 6.80e-01 | 0.1666 |
54663 | WDR74 | LP15 | Human | Oral cavity | LP | 3.77e-05 | 9.73e-01 | 0.2174 |
54663 | WDR74 | LP17 | Human | Oral cavity | LP | 2.44e-03 | 1.10e+00 | 0.2349 |
54663 | WDR74 | SYSMH1 | Human | Oral cavity | OSCC | 4.15e-09 | 2.13e-01 | 0.1127 |
54663 | WDR74 | SYSMH2 | Human | Oral cavity | OSCC | 6.45e-27 | 8.58e-01 | 0.2326 |
54663 | WDR74 | SYSMH3 | Human | Oral cavity | OSCC | 2.88e-42 | 1.02e+00 | 0.2442 |
54663 | WDR74 | SYSMH4 | Human | Oral cavity | OSCC | 1.95e-07 | 1.79e-01 | 0.1226 |
54663 | WDR74 | SYSMH5 | Human | Oral cavity | OSCC | 1.16e-14 | 4.82e-01 | 0.0647 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:004227326 | Esophagus | HGIN | ribosomal large subunit biogenesis | 34/2587 | 72/18723 | 8.82e-12 | 1.06e-09 | 34 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:000170118 | Esophagus | HGIN | in utero embryonic development | 77/2587 | 367/18723 | 9.56e-05 | 2.05e-03 | 77 |
GO:00018244 | Esophagus | HGIN | blastocyst development | 28/2587 | 106/18723 | 4.30e-04 | 6.47e-03 | 28 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
GO:00018253 | Esophagus | ESCC | blastocyst formation | 29/8552 | 38/18723 | 1.18e-04 | 8.13e-04 | 29 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR74 | SNV | Missense_Mutation | c.664G>C | p.Glu222Gln | p.E222Q | Q6RFH5 | protein_coding | tolerated(0.08) | possibly_damaging(0.649) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WDR74 | insertion | Nonsense_Mutation | novel | c.372_373insAGAGAAGAGGCATACATCTAAGATGAGAAAGTTTCTGGGAGTGGAT | p.Leu125ArgfsTer7 | p.L125Rfs*7 | Q6RFH5 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
WDR74 | SNV | Missense_Mutation | rs766243027 | c.140N>T | p.Ala47Val | p.A47V | Q6RFH5 | protein_coding | tolerated(0.13) | benign(0.006) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR74 | insertion | Frame_Shift_Ins | novel | c.741_742insT | p.His248SerfsTer8 | p.H248Sfs*8 | Q6RFH5 | protein_coding | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
WDR74 | SNV | Missense_Mutation | c.351G>T | p.Lys117Asn | p.K117N | Q6RFH5 | protein_coding | tolerated(0.3) | probably_damaging(0.987) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
WDR74 | SNV | Missense_Mutation | c.712N>A | p.Gly238Arg | p.G238R | Q6RFH5 | protein_coding | tolerated(0.35) | benign(0.031) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
WDR74 | SNV | Missense_Mutation | c.878T>G | p.Leu293Trp | p.L293W | Q6RFH5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WDR74 | SNV | Missense_Mutation | c.991G>C | p.Glu331Gln | p.E331Q | Q6RFH5 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-DC-4745-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
WDR74 | SNV | Missense_Mutation | c.915N>T | p.Glu305Asp | p.E305D | Q6RFH5 | protein_coding | tolerated(0.36) | possibly_damaging(0.451) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR74 | SNV | Missense_Mutation | rs200001030 | c.650N>A | p.Arg217His | p.R217H | Q6RFH5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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