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Gene: WDR41 |
Gene summary for WDR41 |
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Gene information | Species | Human | Gene symbol | WDR41 | Gene ID | 55255 |
Gene name | WD repeat domain 41 | |
Gene Alias | MSTP048 | |
Cytomap | 5q13.3-q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | A0A0S2Z5E0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55255 | WDR41 | C21 | Human | Oral cavity | OSCC | 2.71e-36 | 9.98e-01 | 0.2678 |
55255 | WDR41 | C30 | Human | Oral cavity | OSCC | 1.17e-32 | 1.31e+00 | 0.3055 |
55255 | WDR41 | C38 | Human | Oral cavity | OSCC | 9.66e-07 | 8.24e-01 | 0.172 |
55255 | WDR41 | C43 | Human | Oral cavity | OSCC | 5.98e-25 | 5.64e-01 | 0.1704 |
55255 | WDR41 | C46 | Human | Oral cavity | OSCC | 2.83e-07 | 3.02e-01 | 0.1673 |
55255 | WDR41 | C51 | Human | Oral cavity | OSCC | 3.92e-02 | 2.49e-01 | 0.2674 |
55255 | WDR41 | C06 | Human | Oral cavity | OSCC | 1.26e-03 | 5.97e-01 | 0.2699 |
55255 | WDR41 | C07 | Human | Oral cavity | OSCC | 2.12e-03 | 7.04e-01 | 0.2491 |
55255 | WDR41 | C08 | Human | Oral cavity | OSCC | 6.20e-26 | 5.60e-01 | 0.1919 |
55255 | WDR41 | C09 | Human | Oral cavity | OSCC | 5.26e-05 | 2.07e-01 | 0.1431 |
55255 | WDR41 | LN46 | Human | Oral cavity | OSCC | 2.21e-05 | 3.68e-01 | 0.1666 |
55255 | WDR41 | EOLP-1 | Human | Oral cavity | EOLP | 5.74e-06 | 2.08e-01 | -0.0202 |
55255 | WDR41 | NEOLP-2 | Human | Oral cavity | NEOLP | 7.57e-03 | 1.38e-01 | -0.0196 |
55255 | WDR41 | SYSMH1 | Human | Oral cavity | OSCC | 1.61e-03 | 1.28e-01 | 0.1127 |
55255 | WDR41 | SYSMH2 | Human | Oral cavity | OSCC | 5.49e-08 | 2.63e-01 | 0.2326 |
55255 | WDR41 | SYSMH3 | Human | Oral cavity | OSCC | 1.19e-06 | 2.57e-01 | 0.2442 |
55255 | WDR41 | HTA12-23-1 | Human | Pancreas | PDAC | 2.35e-03 | 5.59e-01 | 0.3405 |
55255 | WDR41 | HTA12-25-1 | Human | Pancreas | PDAC | 1.93e-05 | 5.93e-01 | 0.313 |
55255 | WDR41 | HTA12-26-1 | Human | Pancreas | PDAC | 2.42e-03 | 3.93e-01 | 0.3728 |
55255 | WDR41 | HTA12-29-1 | Human | Pancreas | PDAC | 1.70e-06 | 2.70e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00105063 | Colorectum | FAP | regulation of autophagy | 80/2622 | 317/18723 | 6.43e-08 | 4.54e-06 | 80 |
GO:00105064 | Colorectum | CRC | regulation of autophagy | 62/2078 | 317/18723 | 6.04e-06 | 2.35e-04 | 62 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:001050610 | Oral cavity | OSCC | regulation of autophagy | 198/7305 | 317/18723 | 1.63e-17 | 1.51e-15 | 198 |
GO:001050622 | Oral cavity | EOLP | regulation of autophagy | 74/2218 | 317/18723 | 5.84e-09 | 3.07e-07 | 74 |
GO:001050631 | Oral cavity | NEOLP | regulation of autophagy | 60/2005 | 317/18723 | 8.06e-06 | 1.57e-04 | 60 |
GO:001050619 | Skin | cSCC | regulation of autophagy | 127/4864 | 317/18723 | 2.36e-08 | 6.71e-07 | 127 |
GO:0010506110 | Thyroid | PTC | regulation of autophagy | 172/5968 | 317/18723 | 8.76e-17 | 7.57e-15 | 172 |
GO:001050632 | Thyroid | ATC | regulation of autophagy | 180/6293 | 317/18723 | 1.34e-17 | 1.46e-15 | 180 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa050224 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa050144 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa050225 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa050145 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa050228 | Colorectum | FAP | Pathways of neurodegeneration - multiple diseases | 117/1404 | 476/8465 | 2.81e-06 | 4.47e-05 | 2.72e-05 | 117 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa050229 | Colorectum | FAP | Pathways of neurodegeneration - multiple diseases | 117/1404 | 476/8465 | 2.81e-06 | 4.47e-05 | 2.72e-05 | 117 |
hsa050149 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR41 | SNV | Missense_Mutation | rs370753681 | c.121N>C | p.Ala41Pro | p.A41P | Q9HAD4 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
WDR41 | SNV | Missense_Mutation | novel | c.1004G>T | p.Arg335Met | p.R335M | Q9HAD4 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR41 | SNV | Missense_Mutation | c.893N>A | p.Ala298Asp | p.A298D | Q9HAD4 | protein_coding | deleterious(0) | benign(0.303) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
WDR41 | SNV | Missense_Mutation | c.877N>A | p.Glu293Lys | p.E293K | Q9HAD4 | protein_coding | tolerated(0.33) | benign(0.214) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
WDR41 | SNV | Missense_Mutation | rs144473455 | c.140N>A | p.Arg47Gln | p.R47Q | Q9HAD4 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WDR41 | SNV | Missense_Mutation | rs765902291 | c.692T>C | p.Val231Ala | p.V231A | Q9HAD4 | protein_coding | deleterious(0) | benign(0.166) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR41 | SNV | Missense_Mutation | novel | c.1090N>G | p.Thr364Ala | p.T364A | Q9HAD4 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
WDR41 | SNV | Missense_Mutation | novel | c.258N>T | p.Lys86Asn | p.K86N | Q9HAD4 | protein_coding | tolerated(0.06) | probably_damaging(0.978) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WDR41 | SNV | Missense_Mutation | novel | c.31N>A | p.Glu11Lys | p.E11K | Q9HAD4 | protein_coding | tolerated(0.15) | benign(0.133) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WDR41 | insertion | Frame_Shift_Ins | rs748110033 | c.1101_1102insT | p.Asn368Ter | p.N368* | Q9HAD4 | protein_coding | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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