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Gene: WBP1 |
Gene summary for WBP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | WBP1 | Gene ID | 23559 |
| Gene name | WW domain binding protein 1 | |
| Gene Alias | WBP-1 | |
| Cytomap | 2p13.1 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96G27 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23559 | WBP1 | P52T-E | Human | Esophagus | ESCC | 7.96e-34 | 7.91e-01 | 0.1555 |
| 23559 | WBP1 | P54T-E | Human | Esophagus | ESCC | 2.89e-40 | 8.53e-01 | 0.0975 |
| 23559 | WBP1 | P56T-E | Human | Esophagus | ESCC | 3.40e-21 | 2.20e+00 | 0.1613 |
| 23559 | WBP1 | P57T-E | Human | Esophagus | ESCC | 1.94e-58 | 1.10e+00 | 0.0926 |
| 23559 | WBP1 | P61T-E | Human | Esophagus | ESCC | 3.05e-51 | 1.09e+00 | 0.099 |
| 23559 | WBP1 | P62T-E | Human | Esophagus | ESCC | 1.24e-63 | 1.03e+00 | 0.1302 |
| 23559 | WBP1 | P65T-E | Human | Esophagus | ESCC | 4.21e-41 | 7.48e-01 | 0.0978 |
| 23559 | WBP1 | P74T-E | Human | Esophagus | ESCC | 4.04e-53 | 1.20e+00 | 0.1479 |
| 23559 | WBP1 | P75T-E | Human | Esophagus | ESCC | 1.66e-81 | 1.31e+00 | 0.1125 |
| 23559 | WBP1 | P76T-E | Human | Esophagus | ESCC | 2.48e-48 | 8.86e-01 | 0.1207 |
| 23559 | WBP1 | P79T-E | Human | Esophagus | ESCC | 4.38e-73 | 1.19e+00 | 0.1154 |
| 23559 | WBP1 | P80T-E | Human | Esophagus | ESCC | 1.52e-54 | 1.38e+00 | 0.155 |
| 23559 | WBP1 | P82T-E | Human | Esophagus | ESCC | 7.38e-36 | 1.83e+00 | 0.1072 |
| 23559 | WBP1 | P83T-E | Human | Esophagus | ESCC | 4.70e-51 | 1.35e+00 | 0.1738 |
| 23559 | WBP1 | P84T-E | Human | Esophagus | ESCC | 2.03e-17 | 9.78e-01 | 0.0933 |
| 23559 | WBP1 | P89T-E | Human | Esophagus | ESCC | 4.96e-25 | 1.40e+00 | 0.1752 |
| 23559 | WBP1 | P91T-E | Human | Esophagus | ESCC | 5.78e-19 | 1.47e+00 | 0.1828 |
| 23559 | WBP1 | P104T-E | Human | Esophagus | ESCC | 3.40e-08 | 6.84e-01 | 0.0931 |
| 23559 | WBP1 | P107T-E | Human | Esophagus | ESCC | 3.54e-34 | 7.17e-01 | 0.171 |
| 23559 | WBP1 | P126T-E | Human | Esophagus | ESCC | 1.56e-10 | 6.74e-01 | 0.1125 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
| GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
| GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
| GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
| GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
| GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
| GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
| GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
| GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
| GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
| GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
| GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
| GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
| GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
| GO:00226133 | Colorectum | MSI-H | ribonucleoprotein complex biogenesis | 95/1319 | 463/18723 | 1.04e-21 | 8.32e-19 | 95 |
| GO:00083803 | Colorectum | MSI-H | RNA splicing | 82/1319 | 434/18723 | 1.22e-16 | 4.53e-14 | 82 |
| GO:00003753 | Colorectum | MSI-H | RNA splicing, via transesterification reactions | 67/1319 | 324/18723 | 7.99e-16 | 2.61e-13 | 67 |
| GO:00003773 | Colorectum | MSI-H | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
| GO:00003983 | Colorectum | MSI-H | mRNA splicing, via spliceosome | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
| GO:00422543 | Colorectum | MSI-H | ribosome biogenesis | 54/1319 | 299/18723 | 1.27e-10 | 2.07e-08 | 54 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| WBP1 | SNV | Missense_Mutation | novel | c.249N>T | p.Arg83Ser | p.R83S | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
| WBP1 | SNV | Missense_Mutation | novel | c.274N>C | p.Glu92Gln | p.E92Q | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| WBP1 | SNV | Missense_Mutation | c.31N>C | p.Glu11Gln | p.E11Q | Q96G27 | protein_coding | deleterious_low_confidence(0.01) | benign(0.171) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| WBP1 | insertion | Frame_Shift_Ins | rs547055147 | c.551dupC | p.His185SerfsTer5 | p.H185Sfs*5 | Q96G27 | protein_coding | TCGA-C5-A7CM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
| WBP1 | SNV | Missense_Mutation | c.458N>A | p.Ser153Asn | p.S153N | Q96G27 | protein_coding | deleterious(0.04) | benign(0) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| WBP1 | SNV | Missense_Mutation | novel | c.278N>A | p.Ile93Asn | p.I93N | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delN | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
| WBP1 | deletion | Frame_Shift_Del | c.545delN | p.Pro184LeufsTer11 | p.P184Lfs*11 | Q96G27 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
| WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delT | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delN | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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