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Gene: UBTD1 |
Gene summary for UBTD1 |
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Gene information | Species | Human | Gene symbol | UBTD1 | Gene ID | 80019 |
Gene name | ubiquitin domain containing 1 | |
Gene Alias | UBTD1 | |
Cytomap | 10q24.1-q24.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9HAC8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80019 | UBTD1 | ATC1 | Human | Thyroid | ATC | 7.00e-12 | 4.51e-01 | 0.2878 |
80019 | UBTD1 | ATC2 | Human | Thyroid | ATC | 2.71e-04 | 3.90e-01 | 0.34 |
80019 | UBTD1 | ATC3 | Human | Thyroid | ATC | 3.97e-04 | 2.82e-01 | 0.338 |
80019 | UBTD1 | ATC4 | Human | Thyroid | ATC | 6.52e-36 | 7.31e-01 | 0.34 |
80019 | UBTD1 | ATC5 | Human | Thyroid | ATC | 3.47e-22 | 3.75e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBTD1 | SNV | Missense_Mutation | rs759421272 | c.514N>A | p.Gly172Arg | p.G172R | Q9HAC8 | protein_coding | tolerated(0.33) | benign(0.055) | TCGA-C5-A7CG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBTD1 | SNV | Missense_Mutation | rs559667337 | c.493G>A | p.Ala165Thr | p.A165T | Q9HAC8 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBTD1 | SNV | Missense_Mutation | novel | c.472G>C | p.Gly158Arg | p.G158R | Q9HAC8 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
UBTD1 | SNV | Missense_Mutation | c.463C>A | p.Leu155Met | p.L155M | Q9HAC8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
UBTD1 | SNV | Missense_Mutation | c.335N>A | p.Arg112His | p.R112H | Q9HAC8 | protein_coding | tolerated(0.15) | probably_damaging(0.97) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
UBTD1 | SNV | Missense_Mutation | c.335N>A | p.Arg112His | p.R112H | Q9HAC8 | protein_coding | tolerated(0.15) | probably_damaging(0.97) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBTD1 | SNV | Missense_Mutation | c.509N>T | p.Thr170Ile | p.T170I | Q9HAC8 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBTD1 | SNV | Missense_Mutation | rs146047099 | c.368C>T | p.Pro123Leu | p.P123L | Q9HAC8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DC-5337-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBTD1 | SNV | Missense_Mutation | novel | c.396N>T | p.Glu132Asp | p.E132D | Q9HAC8 | protein_coding | tolerated(0.68) | benign(0.003) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
UBTD1 | SNV | Missense_Mutation | c.335N>A | p.Arg112His | p.R112H | Q9HAC8 | protein_coding | tolerated(0.15) | probably_damaging(0.97) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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