Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: UBL4A

Gene summary for UBL4A

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UBL4A

Gene ID

8266

Gene nameubiquitin like 4A
Gene AliasDX254E
CytomapXq28
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

P11441


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8266UBL4AC57HumanOral cavityOSCC2.24e-084.13e-010.1679
8266UBL4AC06HumanOral cavityOSCC9.81e-049.62e-010.2699
8266UBL4AC07HumanOral cavityOSCC4.25e-025.38e-010.2491
8266UBL4AC08HumanOral cavityOSCC1.94e-175.19e-010.1919
8266UBL4AC09HumanOral cavityOSCC8.52e-042.31e-010.1431
8266UBL4ALN22HumanOral cavityOSCC3.23e-038.69e-010.1733
8266UBL4ALN46HumanOral cavityOSCC3.81e-074.19e-010.1666
8266UBL4ALP15HumanOral cavityLP6.62e-066.67e-010.2174
8266UBL4ALP17HumanOral cavityLP6.58e-058.81e-010.2349
8266UBL4ASYSMH1HumanOral cavityOSCC5.98e-072.63e-010.1127
8266UBL4ASYSMH2HumanOral cavityOSCC4.03e-105.23e-010.2326
8266UBL4ASYSMH3HumanOral cavityOSCC7.27e-155.25e-010.2442
8266UBL4AP1_cSCCHumanSkincSCC1.12e-226.61e-010.0292
8266UBL4AP2_cSCCHumanSkincSCC1.84e-154.42e-01-0.024
8266UBL4AP4_cSCCHumanSkincSCC2.10e-164.19e-01-0.00290000000000005
8266UBL4AP10_cSCCHumanSkincSCC1.24e-205.55e-010.1017
8266UBL4Amale-WTAHumanThyroidPTC6.39e-081.05e-010.1037
8266UBL4APTC04HumanThyroidPTC1.83e-049.16e-020.1927
8266UBL4APTC05HumanThyroidPTC1.23e-052.82e-010.2065
8266UBL4APTC06HumanThyroidPTC4.18e-152.84e-010.2057
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0090150110EsophagusESCCestablishment of protein localization to membrane182/8552260/187231.27e-158.19e-14182
GO:000702914EsophagusESCCendoplasmic reticulum organization65/855287/187233.28e-086.08e-0765
GO:005120515EsophagusESCCprotein insertion into membrane46/855257/187235.90e-081.04e-0646
GO:004504812EsophagusESCCprotein insertion into ER membrane21/855222/187238.75e-071.13e-0521
GO:007181611EsophagusESCCtail-anchored membrane protein insertion into ER membrane17/855217/187231.63e-061.95e-0517
GO:009015012LiverHCCestablishment of protein localization to membrane168/7958260/187234.07e-132.13e-11168
GO:000702911LiverHCCendoplasmic reticulum organization64/795887/187233.92e-091.04e-0764
GO:005120511LiverHCCprotein insertion into membrane41/795857/187236.42e-067.83e-0541
GO:0071816LiverHCCtail-anchored membrane protein insertion into ER membrane15/795817/187231.31e-041.07e-0315
GO:00450481LiverHCCprotein insertion into ER membrane18/795822/187231.91e-041.49e-0318
GO:009015018Oral cavityOSCCestablishment of protein localization to membrane163/7305260/187237.13e-154.47e-13163
GO:00070294Oral cavityOSCCendoplasmic reticulum organization58/730587/187231.59e-072.61e-0658
GO:00512056Oral cavityOSCCprotein insertion into membrane40/730557/187231.81e-062.34e-0540
GO:00450482Oral cavityOSCCprotein insertion into ER membrane17/730522/187232.99e-041.87e-0317
GO:00718162Oral cavityOSCCtail-anchored membrane protein insertion into ER membrane14/730517/187233.31e-042.04e-0314
GO:009015019Oral cavityLPestablishment of protein localization to membrane128/4623260/187237.19e-181.19e-15128
GO:005120514Oral cavityLPprotein insertion into membrane35/462357/187234.38e-091.86e-0735
GO:000702913Oral cavityLPendoplasmic reticulum organization41/462387/187234.49e-069.16e-0541
GO:004504811Oral cavityLPprotein insertion into ER membrane15/462322/187232.08e-053.44e-0415
GO:00718161Oral cavityLPtail-anchored membrane protein insertion into ER membrane12/462317/187238.70e-051.10e-0312
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UBL4AinsertionFrame_Shift_Insnovelc.385_386insCAATCATTTTGp.Arg129ProfsTer6p.R129Pfs*6P11441protein_codingTCGA-E9-A1NI-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinCR
UBL4ASNVMissense_Mutationrs141549549c.422N>Ap.Arg141Hisp.R141HP11441protein_codingtolerated(0.39)probably_damaging(0.991)TCGA-HM-A4S6-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
UBL4ASNVMissense_Mutationc.255N>Tp.Gln85Hisp.Q85HP11441protein_codingtolerated(0.39)benign(0)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
UBL4ASNVMissense_Mutationc.331N>Tp.Asp111Tyrp.D111YP11441protein_codingdeleterious(0)probably_damaging(0.997)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
UBL4ASNVMissense_Mutationrs782395991c.326N>Tp.Ala109Valp.A109VP11441protein_codingdeleterious(0.05)benign(0)TCGA-B5-A0K4-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinSD
UBL4ASNVMissense_Mutationrs782531758c.170N>Tp.Ser57Leup.S57LP11441protein_codingdeleterious(0)probably_damaging(0.994)TCGA-B5-A0K9-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
UBL4ASNVMissense_Mutationrs782283486c.265G>Ap.Asp89Asnp.D89NP11441protein_codingtolerated(0.35)benign(0.054)TCGA-BK-A0CC-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVChemotherapytaxolPD
UBL4ASNVMissense_Mutationc.362N>Tp.Arg121Metp.R121MP11441protein_codingdeleterious(0)possibly_damaging(0.781)TCGA-D1-A0ZO-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
UBL4ASNVMissense_Mutationc.282N>Tp.Gln94Hisp.Q94HP11441protein_codingtolerated(0.11)benign(0.001)TCGA-D1-A0ZO-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
UBL4ASNVMissense_Mutationnovelc.427N>Ap.Leu143Metp.L143MP11441protein_codingdeleterious(0)probably_damaging(0.996)TCGA-EY-A1GI-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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