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Gene: UBAP1 |
Gene summary for UBAP1 |
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Gene information | Species | Human | Gene symbol | UBAP1 | Gene ID | 51271 |
Gene name | ubiquitin associated protein 1 | |
Gene Alias | NAG20 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9NZ09 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51271 | UBAP1 | P130T-E | Human | Esophagus | ESCC | 6.33e-54 | 1.35e+00 | 0.1676 |
51271 | UBAP1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.31e-12 | 1.40e+00 | 0.3371 |
51271 | UBAP1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 2.19e-08 | 1.22e+00 | 0.343 |
51271 | UBAP1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 2.48e-10 | 1.23e+00 | 0.3385 |
51271 | UBAP1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.45e-09 | 1.18e+00 | 0.3329 |
51271 | UBAP1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 3.13e-03 | 4.17e-01 | 0.1859 |
51271 | UBAP1 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.39e-02 | 6.39e-01 | -0.0238 |
51271 | UBAP1 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 6.52e-03 | 5.86e-01 | -0.0296 |
51271 | UBAP1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 7.87e-12 | 4.41e-01 | -0.0166 |
51271 | UBAP1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.54e-14 | 4.66e-01 | -0.0132 |
51271 | UBAP1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 6.45e-15 | 4.21e-01 | -0.013 |
51271 | UBAP1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 6.43e-11 | 4.71e-01 | -0.0121 |
51271 | UBAP1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.36e-04 | 4.42e-01 | -0.0961 |
51271 | UBAP1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.04e-04 | 5.51e-01 | -0.0876 |
51271 | UBAP1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.53e-05 | 5.03e-01 | -0.0822 |
51271 | UBAP1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 4.47e-02 | 4.02e-01 | -0.0809 |
51271 | UBAP1 | C04 | Human | Oral cavity | OSCC | 1.33e-06 | 6.65e-01 | 0.2633 |
51271 | UBAP1 | C21 | Human | Oral cavity | OSCC | 4.04e-22 | 9.04e-01 | 0.2678 |
51271 | UBAP1 | C30 | Human | Oral cavity | OSCC | 1.13e-31 | 1.75e+00 | 0.3055 |
51271 | UBAP1 | C38 | Human | Oral cavity | OSCC | 4.63e-06 | 1.05e+00 | 0.172 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00431623 | Esophagus | ESCC | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00431622 | Oral cavity | OSCC | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 17/7305 | 23/18723 | 7.28e-04 | 3.98e-03 | 17 |
GO:004316211 | Oral cavity | LP | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 13/4623 | 23/18723 | 1.09e-03 | 9.03e-03 | 13 |
GO:00431624 | Skin | cSCC | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 14/4864 | 23/18723 | 4.32e-04 | 3.34e-03 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBAP1 | SNV | Missense_Mutation | novel | c.978T>A | p.Asn326Lys | p.N326K | Q9NZ09 | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBAP1 | SNV | Missense_Mutation | c.224N>T | p.Ser75Leu | p.S75L | Q9NZ09 | protein_coding | deleterious(0.02) | benign(0.349) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UBAP1 | SNV | Missense_Mutation | c.533N>T | p.Pro178Leu | p.P178L | Q9NZ09 | protein_coding | tolerated(0.05) | possibly_damaging(0.864) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
UBAP1 | insertion | In_Frame_Ins | novel | c.780_781insCAACCTGTTCATCATAATCTAATAGATAGTGGTTTAAGA | p.Leu260_Asp261insGlnProValHisHisAsnLeuIleAspSerGlyLeuArg | p.L260_D261insQPVHHNLIDSGLR | Q9NZ09 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
UBAP1 | insertion | Frame_Shift_Ins | novel | c.1097_1098insGATTAAGAAAATCGAAGAAGCCGAGCGGGAAGCAGAGTGCA | p.Lys367IlefsTer36 | p.K367Ifs*36 | Q9NZ09 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
UBAP1 | insertion | Frame_Shift_Ins | novel | c.1699_1700insCTAGAGACTTTGGGATAGAGTTAGCTCCAAAGTGG | p.Ter567SerfsTer50 | p.*567Sfs*50 | Q9NZ09 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
UBAP1 | insertion | Frame_Shift_Ins | novel | c.980_981insTGCGGAAGCAGAAGCTAAAGTGAATTCTAAGAGTGGCC | p.Lys328AlafsTer52 | p.K328Afs*52 | Q9NZ09 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
UBAP1 | insertion | Frame_Shift_Ins | novel | c.576_577insCTCAATTTCTTCATCTGTAAAGGGAGGATGAGGATGATTAGCTTTTA | p.Ile193LeufsTer16 | p.I193Lfs*16 | Q9NZ09 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
UBAP1 | insertion | Frame_Shift_Ins | novel | c.588_589insTCCC | p.Thr197SerfsTer7 | p.T197Sfs*7 | Q9NZ09 | protein_coding | TCGA-A8-A0AB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
UBAP1 | insertion | In_Frame_Ins | novel | c.590_591insACGCCTTAAATGCTGCCT | p.Arg198_Val199insLeuLysCysCysLeuArg | p.R198_V199insLKCCLR | Q9NZ09 | protein_coding | TCGA-A8-A0AB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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