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Gene: TSFM |
Gene summary for TSFM |
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Gene information | Species | Human | Gene symbol | TSFM | Gene ID | 10102 |
Gene name | Ts translation elongation factor, mitochondrial | |
Gene Alias | EFTS | |
Cytomap | 12q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P43897 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10102 | TSFM | S015 | Human | Liver | HCC | 2.72e-12 | 6.72e-01 | 0.2375 |
10102 | TSFM | S016 | Human | Liver | HCC | 7.22e-11 | 4.82e-01 | 0.2243 |
10102 | TSFM | S027 | Human | Liver | HCC | 6.94e-03 | 4.75e-01 | 0.2446 |
10102 | TSFM | S028 | Human | Liver | HCC | 6.41e-08 | 5.17e-01 | 0.2503 |
10102 | TSFM | S029 | Human | Liver | HCC | 8.45e-15 | 9.16e-01 | 0.2581 |
10102 | TSFM | C04 | Human | Oral cavity | OSCC | 5.29e-16 | 9.92e-01 | 0.2633 |
10102 | TSFM | C21 | Human | Oral cavity | OSCC | 1.53e-52 | 1.32e+00 | 0.2678 |
10102 | TSFM | C30 | Human | Oral cavity | OSCC | 2.24e-22 | 1.17e+00 | 0.3055 |
10102 | TSFM | C38 | Human | Oral cavity | OSCC | 1.13e-04 | 6.98e-01 | 0.172 |
10102 | TSFM | C43 | Human | Oral cavity | OSCC | 3.49e-26 | 5.12e-01 | 0.1704 |
10102 | TSFM | C46 | Human | Oral cavity | OSCC | 5.24e-18 | 4.69e-01 | 0.1673 |
10102 | TSFM | C51 | Human | Oral cavity | OSCC | 4.49e-08 | 5.50e-01 | 0.2674 |
10102 | TSFM | C57 | Human | Oral cavity | OSCC | 4.74e-08 | 4.70e-01 | 0.1679 |
10102 | TSFM | C06 | Human | Oral cavity | OSCC | 9.99e-04 | 9.77e-01 | 0.2699 |
10102 | TSFM | C07 | Human | Oral cavity | OSCC | 4.58e-05 | 1.25e+00 | 0.2491 |
10102 | TSFM | C08 | Human | Oral cavity | OSCC | 1.26e-20 | 4.84e-01 | 0.1919 |
10102 | TSFM | C09 | Human | Oral cavity | OSCC | 3.61e-03 | 1.66e-01 | 0.1431 |
10102 | TSFM | LN22 | Human | Oral cavity | OSCC | 1.96e-06 | 1.00e+00 | 0.1733 |
10102 | TSFM | LN38 | Human | Oral cavity | OSCC | 2.14e-03 | 7.06e-01 | 0.168 |
10102 | TSFM | LN46 | Human | Oral cavity | OSCC | 4.65e-05 | 3.54e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:0006414 | Colorectum | AD | translational elongation | 21/3918 | 55/18723 | 2.53e-03 | 1.93e-02 | 21 |
GO:00064171 | Colorectum | SER | regulation of translation | 100/2897 | 468/18723 | 3.76e-04 | 5.74e-03 | 100 |
GO:00064141 | Colorectum | SER | translational elongation | 17/2897 | 55/18723 | 3.00e-03 | 2.65e-02 | 17 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:00063541 | Colorectum | MSS | DNA-templated transcription, elongation | 29/3467 | 91/18723 | 1.52e-03 | 1.39e-02 | 29 |
GO:00064142 | Colorectum | MSS | translational elongation | 19/3467 | 55/18723 | 3.47e-03 | 2.59e-02 | 19 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:003278412 | Esophagus | ESCC | regulation of DNA-templated transcription, elongation | 45/8552 | 53/18723 | 3.64e-09 | 7.61e-08 | 45 |
GO:00701292 | Esophagus | ESCC | regulation of mitochondrial translation | 22/8552 | 24/18723 | 2.82e-06 | 3.21e-05 | 22 |
GO:000641419 | Esophagus | ESCC | translational elongation | 41/8552 | 55/18723 | 1.26e-05 | 1.16e-04 | 41 |
GO:00621252 | Esophagus | ESCC | regulation of mitochondrial gene expression | 24/8552 | 28/18723 | 1.37e-05 | 1.25e-04 | 24 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
GO:00063544 | Liver | Cirrhotic | DNA-templated transcription, elongation | 35/4634 | 91/18723 | 2.56e-03 | 1.53e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSFM | SNV | Missense_Mutation | novel | c.70N>A | p.Leu24Met | p.L24M | P43897 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.584) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSFM | SNV | Missense_Mutation | c.389N>T | p.Arg130Ile | p.R130I | P43897 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSFM | SNV | Missense_Mutation | c.145N>T | p.Leu49Phe | p.L49F | P43897 | protein_coding | tolerated(0.18) | probably_damaging(0.94) | TCGA-BH-A18H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
TSFM | SNV | Missense_Mutation | rs770248416 | c.67N>G | p.Leu23Val | p.L23V | P43897 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TSFM | SNV | Missense_Mutation | c.244C>T | p.Leu82Phe | p.L82F | P43897 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TSFM | SNV | Missense_Mutation | novel | c.209N>G | p.Thr70Ser | p.T70S | P43897 | protein_coding | tolerated(0.61) | benign(0.006) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TSFM | SNV | Missense_Mutation | c.362N>C | p.Val121Ala | p.V121A | P43897 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TSFM | SNV | Missense_Mutation | novel | c.685C>T | p.Pro229Ser | p.P229S | P43897 | protein_coding | deleterious(0.03) | possibly_damaging(0.661) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TSFM | SNV | Missense_Mutation | novel | c.287A>G | p.Lys96Arg | p.K96R | P43897 | protein_coding | deleterious(0.04) | possibly_damaging(0.799) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TSFM | SNV | Missense_Mutation | rs767624430 | c.827N>A | p.Arg276His | p.R276H | P43897 | protein_coding | tolerated(0.11) | benign(0.03) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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