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Gene: TRMT6 |
Gene summary for TRMT6 |
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Gene information | Species | Human | Gene symbol | TRMT6 | Gene ID | 51605 |
Gene name | tRNA methyltransferase 6 non-catalytic subunit | |
Gene Alias | CGI-09 | |
Cytomap | 20p12.3 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q9UJA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51605 | TRMT6 | LN22 | Human | Oral cavity | OSCC | 4.45e-02 | 4.45e-01 | 0.1733 |
51605 | TRMT6 | LN38 | Human | Oral cavity | OSCC | 1.70e-02 | 8.02e-01 | 0.168 |
51605 | TRMT6 | LN46 | Human | Oral cavity | OSCC | 4.41e-15 | 6.17e-01 | 0.1666 |
51605 | TRMT6 | SYSMH1 | Human | Oral cavity | OSCC | 2.05e-09 | 2.58e-01 | 0.1127 |
51605 | TRMT6 | SYSMH2 | Human | Oral cavity | OSCC | 1.42e-16 | 5.39e-01 | 0.2326 |
51605 | TRMT6 | SYSMH3 | Human | Oral cavity | OSCC | 2.74e-26 | 6.06e-01 | 0.2442 |
51605 | TRMT6 | SYSMH4 | Human | Oral cavity | OSCC | 4.03e-02 | 7.76e-02 | 0.1226 |
51605 | TRMT6 | SYSMH5 | Human | Oral cavity | OSCC | 6.73e-05 | 2.73e-01 | 0.0647 |
51605 | TRMT6 | P4_S8_cSCC | Human | Skin | cSCC | 6.27e-03 | 1.06e-01 | -0.3095 |
51605 | TRMT6 | P5_S10_cSCC | Human | Skin | cSCC | 1.89e-06 | 1.77e-01 | -0.299 |
51605 | TRMT6 | P1_cSCC | Human | Skin | cSCC | 1.63e-16 | 7.13e-01 | 0.0292 |
51605 | TRMT6 | P2_cSCC | Human | Skin | cSCC | 1.98e-08 | 4.15e-01 | -0.024 |
51605 | TRMT6 | P4_cSCC | Human | Skin | cSCC | 1.12e-30 | 8.20e-01 | -0.00290000000000005 |
51605 | TRMT6 | P10_cSCC | Human | Skin | cSCC | 2.56e-25 | 8.22e-01 | 0.1017 |
51605 | TRMT6 | cSCC_p9 | Human | Skin | cSCC | 1.57e-04 | 9.10e-02 | -0.1991 |
51605 | TRMT6 | male-WTA | Human | Thyroid | PTC | 4.74e-11 | 9.85e-02 | 0.1037 |
51605 | TRMT6 | PTC01 | Human | Thyroid | PTC | 7.79e-07 | 7.12e-02 | 0.1899 |
51605 | TRMT6 | PTC04 | Human | Thyroid | PTC | 9.29e-04 | 7.64e-02 | 0.1927 |
51605 | TRMT6 | PTC05 | Human | Thyroid | PTC | 2.74e-05 | 2.58e-01 | 0.2065 |
51605 | TRMT6 | PTC06 | Human | Thyroid | PTC | 4.87e-10 | 2.79e-01 | 0.2057 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
GO:00009631 | Esophagus | ESCC | mitochondrial RNA processing | 19/8552 | 20/18723 | 3.83e-06 | 4.14e-05 | 19 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00800092 | Esophagus | ESCC | mRNA methylation | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00165561 | Esophagus | ESCC | mRNA modification | 21/8552 | 27/18723 | 6.88e-04 | 3.61e-03 | 21 |
GO:0090646 | Esophagus | ESCC | mitochondrial tRNA processing | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRMT6 | SNV | Missense_Mutation | rs544190283 | c.712N>T | p.Arg238Trp | p.R238W | Q9UJA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRMT6 | SNV | Missense_Mutation | c.1439A>C | p.His480Pro | p.H480P | Q9UJA5 | protein_coding | tolerated_low_confidence(0.22) | benign(0) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TRMT6 | SNV | Missense_Mutation | novel | c.188G>C | p.Gly63Ala | p.G63A | Q9UJA5 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TRMT6 | deletion | Frame_Shift_Del | novel | c.607delN | p.Met203Ter | p.M203* | Q9UJA5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TRMT6 | deletion | Frame_Shift_Del | rs780358338 | c.458delA | p.Lys153AsnfsTer9 | p.K153Nfs*9 | Q9UJA5 | protein_coding | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
TRMT6 | SNV | Missense_Mutation | c.125G>A | p.Arg42Lys | p.R42K | Q9UJA5 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TRMT6 | SNV | Missense_Mutation | c.1255G>T | p.Gly419Trp | p.G419W | Q9UJA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
TRMT6 | SNV | Missense_Mutation | rs766405213 | c.578N>T | p.Thr193Met | p.T193M | Q9UJA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
TRMT6 | deletion | Frame_Shift_Del | c.147delN | p.Lys49AsnfsTer20 | p.K49Nfs*20 | Q9UJA5 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TRMT6 | deletion | Frame_Shift_Del | rs780358338 | c.458delA | p.Lys153AsnfsTer9 | p.K153Nfs*9 | Q9UJA5 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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