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Gene: TNFRSF12A |
Gene summary for TNFRSF12A |
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Gene information | Species | Human | Gene symbol | TNFRSF12A | Gene ID | 51330 |
Gene name | TNF receptor superfamily member 12A | |
Gene Alias | CD266 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9NP84 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51330 | TNFRSF12A | P65T-E | Human | Esophagus | ESCC | 9.58e-08 | 8.76e-01 | 0.0978 |
51330 | TNFRSF12A | P74T-E | Human | Esophagus | ESCC | 1.40e-13 | 1.24e+00 | 0.1479 |
51330 | TNFRSF12A | P75T-E | Human | Esophagus | ESCC | 1.55e-60 | 2.90e+00 | 0.1125 |
51330 | TNFRSF12A | P76T-E | Human | Esophagus | ESCC | 1.50e-27 | 1.89e+00 | 0.1207 |
51330 | TNFRSF12A | P79T-E | Human | Esophagus | ESCC | 2.10e-26 | 1.67e+00 | 0.1154 |
51330 | TNFRSF12A | P80T-E | Human | Esophagus | ESCC | 2.90e-22 | 1.79e+00 | 0.155 |
51330 | TNFRSF12A | P82T-E | Human | Esophagus | ESCC | 3.66e-09 | 1.99e+00 | 0.1072 |
51330 | TNFRSF12A | P83T-E | Human | Esophagus | ESCC | 8.17e-29 | 2.72e+00 | 0.1738 |
51330 | TNFRSF12A | P89T-E | Human | Esophagus | ESCC | 1.88e-18 | 3.07e+00 | 0.1752 |
51330 | TNFRSF12A | P91T-E | Human | Esophagus | ESCC | 5.68e-26 | 3.36e+00 | 0.1828 |
51330 | TNFRSF12A | P107T-E | Human | Esophagus | ESCC | 1.42e-45 | 2.76e+00 | 0.171 |
51330 | TNFRSF12A | P126T-E | Human | Esophagus | ESCC | 5.13e-13 | 2.37e+00 | 0.1125 |
51330 | TNFRSF12A | P127T-E | Human | Esophagus | ESCC | 1.48e-05 | 6.74e-01 | 0.0826 |
51330 | TNFRSF12A | P128T-E | Human | Esophagus | ESCC | 9.06e-14 | 1.39e+00 | 0.1241 |
51330 | TNFRSF12A | P130T-E | Human | Esophagus | ESCC | 4.28e-42 | 1.90e+00 | 0.1676 |
51330 | TNFRSF12A | NAFLD1 | Human | Liver | NAFLD | 1.01e-02 | -1.15e+00 | -0.04 |
51330 | TNFRSF12A | S41 | Human | Liver | Cirrhotic | 2.92e-11 | -1.15e+00 | -0.0343 |
51330 | TNFRSF12A | S42 | Human | Liver | HCC | 1.50e-04 | -1.01e+00 | -0.0103 |
51330 | TNFRSF12A | S43 | Human | Liver | Cirrhotic | 4.45e-28 | -8.14e-01 | -0.0187 |
51330 | TNFRSF12A | S44 | Human | Liver | HCC | 2.28e-05 | -1.15e+00 | -0.0083 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012356 | Breast | Precancer | positive regulation of apoptotic signaling pathway | 24/1080 | 126/18723 | 1.98e-07 | 1.01e-05 | 24 |
GO:00420609 | Breast | Precancer | wound healing | 48/1080 | 422/18723 | 5.48e-06 | 1.63e-04 | 48 |
GO:20012369 | Breast | Precancer | regulation of extrinsic apoptotic signaling pathway | 24/1080 | 151/18723 | 5.78e-06 | 1.70e-04 | 24 |
GO:00971919 | Breast | Precancer | extrinsic apoptotic signaling pathway | 30/1080 | 219/18723 | 9.42e-06 | 2.50e-04 | 30 |
GO:19030348 | Breast | Precancer | regulation of response to wounding | 19/1080 | 167/18723 | 3.60e-03 | 2.98e-02 | 19 |
GO:200123314 | Breast | IDC | regulation of apoptotic signaling pathway | 82/1434 | 356/18723 | 6.27e-20 | 5.93e-17 | 82 |
GO:200123514 | Breast | IDC | positive regulation of apoptotic signaling pathway | 31/1434 | 126/18723 | 4.13e-09 | 3.35e-07 | 31 |
GO:009719114 | Breast | IDC | extrinsic apoptotic signaling pathway | 42/1434 | 219/18723 | 2.56e-08 | 1.73e-06 | 42 |
GO:200123614 | Breast | IDC | regulation of extrinsic apoptotic signaling pathway | 32/1434 | 151/18723 | 1.07e-07 | 6.26e-06 | 32 |
GO:004206014 | Breast | IDC | wound healing | 55/1434 | 422/18723 | 7.27e-05 | 1.45e-03 | 55 |
GO:20012385 | Breast | IDC | positive regulation of extrinsic apoptotic signaling pathway | 12/1434 | 48/18723 | 2.03e-04 | 3.32e-03 | 12 |
GO:190303413 | Breast | IDC | regulation of response to wounding | 24/1434 | 167/18723 | 2.07e-03 | 1.95e-02 | 24 |
GO:200123324 | Breast | DCIS | regulation of apoptotic signaling pathway | 81/1390 | 356/18723 | 3.51e-20 | 3.31e-17 | 81 |
GO:200123523 | Breast | DCIS | positive regulation of apoptotic signaling pathway | 31/1390 | 126/18723 | 1.96e-09 | 1.76e-07 | 31 |
GO:009719123 | Breast | DCIS | extrinsic apoptotic signaling pathway | 40/1390 | 219/18723 | 9.43e-08 | 5.28e-06 | 40 |
GO:200123623 | Breast | DCIS | regulation of extrinsic apoptotic signaling pathway | 31/1390 | 151/18723 | 1.79e-07 | 9.04e-06 | 31 |
GO:004206024 | Breast | DCIS | wound healing | 54/1390 | 422/18723 | 6.09e-05 | 1.22e-03 | 54 |
GO:200123812 | Breast | DCIS | positive regulation of extrinsic apoptotic signaling pathway | 12/1390 | 48/18723 | 1.51e-04 | 2.55e-03 | 12 |
GO:190303422 | Breast | DCIS | regulation of response to wounding | 24/1390 | 167/18723 | 1.37e-03 | 1.42e-02 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Breast | DCIS |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Breast | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Cervix | ADJ |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Cervix | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Cervix | Precancer |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Endometrium | AEH |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Endometrium | EEC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Endometrium | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Esophagus | ESCC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | ADJ |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | OSCC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | HNSCC | Precancer |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Liver | Healthy |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | AAH |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | IAC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | MIAC |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Lung | Precancer |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Prostate | BPH |
TNFSF12 | TNFRSF12A | TNFSF12_TNFRSF12A | TWEAK | Prostate | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF12A | deletion | Frame_Shift_Del | novel | c.226delC | p.Arg76GlyfsTer11 | p.R76Gfs*11 | Q9NP84 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TNFRSF12A | SNV | Missense_Mutation | rs201879993 | c.358N>A | p.Glu120Lys | p.E120K | Q9NP84 | protein_coding | tolerated(0.15) | benign(0.192) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF12A | SNV | Missense_Mutation | c.305G>A | p.Arg102Lys | p.R102K | Q9NP84 | protein_coding | tolerated(0.15) | probably_damaging(0.924) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TNFRSF12A | SNV | Missense_Mutation | c.244N>T | p.Leu82Phe | p.L82F | Q9NP84 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-38-4629-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TNFRSF12A | SNV | Missense_Mutation | novel | c.332C>G | p.Thr111Ser | p.T111S | Q9NP84 | protein_coding | tolerated(0.06) | probably_damaging(0.968) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
TNFRSF12A | SNV | Missense_Mutation | novel | c.46N>T | p.Gly16Trp | p.G16W | Q9NP84 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-77-7335-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TNFRSF12A | SNV | Missense_Mutation | novel | c.277N>A | p.Gly93Arg | p.G93R | Q9NP84 | protein_coding | deleterious(0.03) | possibly_damaging(0.588) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51330 | TNFRSF12A | DRUGGABLE GENOME | Enavatuzumab | ENAVATUZUMAB | ||
51330 | TNFRSF12A | DRUGGABLE GENOME | agonist | CHEMBL1743011 | ENAVATUZUMAB | |
51330 | TNFRSF12A | DRUGGABLE GENOME | 178101760 |
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