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Gene: TMX2 |
Gene summary for TMX2 |
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Gene information | Species | Human | Gene symbol | TMX2 | Gene ID | 51075 |
Gene name | thioredoxin related transmembrane protein 2 | |
Gene Alias | CGI-31 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9Y320 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51075 | TMX2 | P75T-E | Human | Esophagus | ESCC | 1.51e-44 | 1.07e+00 | 0.1125 |
51075 | TMX2 | P76T-E | Human | Esophagus | ESCC | 1.81e-19 | 4.19e-01 | 0.1207 |
51075 | TMX2 | P79T-E | Human | Esophagus | ESCC | 2.02e-21 | 3.45e-01 | 0.1154 |
51075 | TMX2 | P80T-E | Human | Esophagus | ESCC | 4.33e-43 | 1.25e+00 | 0.155 |
51075 | TMX2 | P82T-E | Human | Esophagus | ESCC | 6.84e-14 | 1.06e+00 | 0.1072 |
51075 | TMX2 | P83T-E | Human | Esophagus | ESCC | 2.70e-36 | 1.15e+00 | 0.1738 |
51075 | TMX2 | P84T-E | Human | Esophagus | ESCC | 5.69e-14 | 6.61e-01 | 0.0933 |
51075 | TMX2 | P89T-E | Human | Esophagus | ESCC | 1.29e-16 | 1.48e+00 | 0.1752 |
51075 | TMX2 | P91T-E | Human | Esophagus | ESCC | 1.80e-23 | 2.53e+00 | 0.1828 |
51075 | TMX2 | P107T-E | Human | Esophagus | ESCC | 2.14e-35 | 1.09e+00 | 0.171 |
51075 | TMX2 | P126T-E | Human | Esophagus | ESCC | 4.70e-08 | 6.89e-01 | 0.1125 |
51075 | TMX2 | P127T-E | Human | Esophagus | ESCC | 7.42e-14 | 8.75e-02 | 0.0826 |
51075 | TMX2 | P128T-E | Human | Esophagus | ESCC | 2.70e-37 | 1.25e+00 | 0.1241 |
51075 | TMX2 | P130T-E | Human | Esophagus | ESCC | 3.53e-37 | 9.56e-01 | 0.1676 |
51075 | TMX2 | HCC1_Meng | Human | Liver | HCC | 2.46e-87 | 2.54e-01 | 0.0246 |
51075 | TMX2 | HCC2_Meng | Human | Liver | HCC | 7.35e-25 | 2.72e-02 | 0.0107 |
51075 | TMX2 | cirrhotic1 | Human | Liver | Cirrhotic | 2.24e-04 | 9.20e-02 | 0.0202 |
51075 | TMX2 | cirrhotic2 | Human | Liver | Cirrhotic | 8.35e-08 | 1.32e-01 | 0.0201 |
51075 | TMX2 | cirrhotic3 | Human | Liver | Cirrhotic | 2.10e-02 | 3.81e-02 | 0.0215 |
51075 | TMX2 | HCC1 | Human | Liver | HCC | 1.51e-12 | 4.41e+00 | 0.5336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMX2 | insertion | In_Frame_Ins | novel | c.184_185insCTTTGGTTGAATTCA | p.Asp62delinsAlaLeuValGluPheAsn | p.D62delinsALVEFN | Q9Y320 | protein_coding | TCGA-BH-A0HL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
TMX2 | SNV | Missense_Mutation | novel | c.85N>G | p.Ser29Ala | p.S29A | Q9Y320 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMX2 | SNV | Missense_Mutation | c.486N>A | p.Phe162Leu | p.F162L | Q9Y320 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TMX2 | SNV | Missense_Mutation | c.758N>A | p.Arg253Gln | p.R253Q | Q9Y320 | protein_coding | tolerated(0.18) | probably_damaging(0.974) | TCGA-DM-A282-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMX2 | SNV | Missense_Mutation | c.518N>G | p.Phe173Cys | p.F173C | Q9Y320 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMX2 | SNV | Missense_Mutation | novel | c.367N>A | p.Phe123Ile | p.F123I | Q9Y320 | protein_coding | tolerated(0.17) | benign(0.03) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMX2 | SNV | Missense_Mutation | rs778852347 | c.787N>T | p.Arg263Trp | p.R263W | Q9Y320 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMX2 | SNV | Missense_Mutation | novel | c.92N>C | p.Leu31Pro | p.L31P | Q9Y320 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
TMX2 | SNV | Missense_Mutation | c.148N>T | p.Pro50Ser | p.P50S | Q9Y320 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMX2 | SNV | Missense_Mutation | rs757544083 | c.593N>A | p.Arg198His | p.R198H | Q9Y320 | protein_coding | deleterious(0.02) | benign(0.219) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51075 | TMX2 | THIOREDOXIN, DRUGGABLE GENOME | ethanol | ALCOHOL | 32451486 |
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