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Gene: TMEM42 |
Gene summary for TMEM42 |
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Gene information | Species | Human | Gene symbol | TMEM42 | Gene ID | 131616 |
Gene name | transmembrane protein 42 | |
Gene Alias | TMEM42 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q69YG0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131616 | TMEM42 | LN46 | Human | Oral cavity | OSCC | 1.26e-05 | 3.95e-01 | 0.1666 |
131616 | TMEM42 | SYSMH1 | Human | Oral cavity | OSCC | 9.27e-07 | 1.52e-01 | 0.1127 |
131616 | TMEM42 | SYSMH2 | Human | Oral cavity | OSCC | 4.11e-06 | 1.39e-01 | 0.2326 |
131616 | TMEM42 | SYSMH3 | Human | Oral cavity | OSCC | 9.99e-05 | 2.13e-01 | 0.2442 |
131616 | TMEM42 | SYSMH4 | Human | Oral cavity | OSCC | 5.42e-03 | 6.63e-02 | 0.1226 |
131616 | TMEM42 | SYSMH6 | Human | Oral cavity | OSCC | 5.53e-07 | 1.50e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM42 | SNV | Missense_Mutation | novel | c.261N>A | p.Phe87Leu | p.F87L | Q69YG0 | protein_coding | tolerated(0.27) | possibly_damaging(0.775) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
TMEM42 | SNV | Missense_Mutation | novel | c.282N>A | p.Phe94Leu | p.F94L | Q69YG0 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM42 | SNV | Missense_Mutation | novel | c.313G>T | p.Val105Leu | p.V105L | Q69YG0 | protein_coding | tolerated(0.07) | benign(0.117) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM42 | SNV | Missense_Mutation | novel | c.282C>A | p.Phe94Leu | p.F94L | Q69YG0 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TMEM42 | SNV | Missense_Mutation | novel | c.301N>A | p.Ala101Thr | p.A101T | Q69YG0 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM42 | SNV | Missense_Mutation | rs139324350 | c.409C>A | p.Leu137Ile | p.L137I | Q69YG0 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM42 | SNV | Missense_Mutation | c.245C>A | p.Ser82Tyr | p.S82Y | Q69YG0 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM42 | SNV | Missense_Mutation | c.245C>A | p.Ser82Tyr | p.S82Y | Q69YG0 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM42 | SNV | Missense_Mutation | novel | c.296C>T | p.Ala99Val | p.A99V | Q69YG0 | protein_coding | tolerated(0.09) | possibly_damaging(0.539) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM42 | SNV | Missense_Mutation | c.402C>A | p.Phe134Leu | p.F134L | Q69YG0 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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