![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM189 |
Gene summary for TMEM189 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM189 | Gene ID | 387521 |
Gene name | plasmanylethanolamine desaturase 1 | |
Gene Alias | CarF | |
Cytomap | 20q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A5PLL7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387521 | TMEM189 | C46 | Human | Oral cavity | OSCC | 4.11e-35 | 8.32e-01 | 0.1673 |
387521 | TMEM189 | C51 | Human | Oral cavity | OSCC | 7.39e-40 | 1.88e+00 | 0.2674 |
387521 | TMEM189 | C57 | Human | Oral cavity | OSCC | 4.12e-31 | 9.89e-01 | 0.1679 |
387521 | TMEM189 | C06 | Human | Oral cavity | OSCC | 1.32e-08 | 1.36e+00 | 0.2699 |
387521 | TMEM189 | C07 | Human | Oral cavity | OSCC | 3.45e-09 | 1.93e+00 | 0.2491 |
387521 | TMEM189 | C08 | Human | Oral cavity | OSCC | 1.89e-41 | 8.99e-01 | 0.1919 |
387521 | TMEM189 | C09 | Human | Oral cavity | OSCC | 1.31e-04 | 2.09e-01 | 0.1431 |
387521 | TMEM189 | LN22 | Human | Oral cavity | OSCC | 5.12e-04 | 1.11e+00 | 0.1733 |
387521 | TMEM189 | LN38 | Human | Oral cavity | OSCC | 1.56e-02 | 5.93e-01 | 0.168 |
387521 | TMEM189 | LN46 | Human | Oral cavity | OSCC | 2.96e-22 | 9.41e-01 | 0.1666 |
387521 | TMEM189 | LP15 | Human | Oral cavity | LP | 1.54e-10 | 1.83e+00 | 0.2174 |
387521 | TMEM189 | LP17 | Human | Oral cavity | LP | 5.63e-08 | 7.36e-01 | 0.2349 |
387521 | TMEM189 | SYSMH1 | Human | Oral cavity | OSCC | 2.49e-91 | 1.61e+00 | 0.1127 |
387521 | TMEM189 | SYSMH2 | Human | Oral cavity | OSCC | 7.55e-31 | 8.29e-01 | 0.2326 |
387521 | TMEM189 | SYSMH3 | Human | Oral cavity | OSCC | 1.05e-33 | 7.81e-01 | 0.2442 |
387521 | TMEM189 | SYSMH5 | Human | Oral cavity | OSCC | 8.11e-11 | 2.92e-01 | 0.0647 |
387521 | TMEM189 | SYSMH6 | Human | Oral cavity | OSCC | 1.32e-06 | 3.16e-01 | 0.1275 |
387521 | TMEM189 | P5_S10_cSCC | Human | Skin | cSCC | 1.32e-16 | 2.59e-01 | -0.299 |
387521 | TMEM189 | P1_cSCC | Human | Skin | cSCC | 1.88e-27 | 8.27e-01 | 0.0292 |
387521 | TMEM189 | P2_cSCC | Human | Skin | cSCC | 5.39e-14 | 4.06e-01 | -0.024 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM189 | SNV | Missense_Mutation | rs201575410 | c.761N>T | p.Thr254Met | p.T254M | A5PLL7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM189 | SNV | Missense_Mutation | novel | c.786N>G | p.Asp262Glu | p.D262E | A5PLL7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A01N-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | SD |
TMEM189 | insertion | Frame_Shift_Ins | novel | c.776_777insAATTT | p.Ala260IlefsTer6 | p.A260Ifs*6 | A5PLL7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |