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Gene: TMEM164 |
Gene summary for TMEM164 |
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Gene information | Species | Human | Gene symbol | TMEM164 | Gene ID | 84187 |
Gene name | transmembrane protein 164 | |
Gene Alias | bB360B22.3 | |
Cytomap | Xq23 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5U3C3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84187 | TMEM164 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 7.48e-07 | 6.74e-01 | -0.2119 |
84187 | TMEM164 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 8.45e-03 | 4.65e-01 | -0.0263 |
84187 | TMEM164 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 9.46e-05 | 1.93e-01 | -0.0166 |
84187 | TMEM164 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.75e-13 | 3.29e-01 | -0.0132 |
84187 | TMEM164 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.78e-15 | 3.42e-01 | -0.013 |
84187 | TMEM164 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 8.09e-10 | 3.82e-01 | -0.0121 |
84187 | TMEM164 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.39e-02 | 4.58e-01 | -0.0809 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM164 | SNV | Missense_Mutation | rs757945538 | c.694G>A | p.Glu232Lys | p.E232K | Q5U3C3 | protein_coding | tolerated(0.17) | benign(0.063) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM164 | SNV | Missense_Mutation | c.745N>A | p.Gly249Ser | p.G249S | Q5U3C3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD | |
TMEM164 | SNV | Missense_Mutation | c.276N>C | p.Lys92Asn | p.K92N | Q5U3C3 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
TMEM164 | SNV | Missense_Mutation | novel | c.358C>T | p.Leu120Phe | p.L120F | Q5U3C3 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-AA-3869-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
TMEM164 | SNV | Missense_Mutation | rs757945538 | c.694N>A | p.Glu232Lys | p.E232K | Q5U3C3 | protein_coding | tolerated(0.17) | benign(0.063) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM164 | SNV | Missense_Mutation | c.556N>A | p.Val186Met | p.V186M | Q5U3C3 | protein_coding | deleterious(0.04) | possibly_damaging(0.698) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD | |
TMEM164 | SNV | Missense_Mutation | c.76N>A | p.Gly26Ser | p.G26S | Q5U3C3 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM164 | SNV | Missense_Mutation | c.521T>C | p.Leu174Ser | p.L174S | Q5U3C3 | protein_coding | tolerated(0.73) | benign(0.053) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM164 | SNV | Missense_Mutation | c.540N>C | p.Gln180His | p.Q180H | Q5U3C3 | protein_coding | tolerated(0.07) | possibly_damaging(0.766) | TCGA-AF-2687-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD | |
TMEM164 | SNV | Missense_Mutation | c.735C>A | p.Asp245Glu | p.D245E | Q5U3C3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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