![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TM9SF1 |
Gene summary for TM9SF1 |
![]() |
Gene information | Species | Human | Gene symbol | TM9SF1 | Gene ID | 10548 |
Gene name | transmembrane 9 superfamily member 1 | |
Gene Alias | HMP70 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | O15321 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10548 | TM9SF1 | S029 | Human | Liver | HCC | 4.69e-02 | 2.62e-01 | 0.2581 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TM9SF1 | SNV | Missense_Mutation | c.208N>A | p.Glu70Lys | p.E70K | O15321 | protein_coding | tolerated(0.23) | benign(0.02) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TM9SF1 | SNV | Missense_Mutation | novel | c.22C>G | p.Arg8Gly | p.R8G | O15321 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TM9SF1 | SNV | Missense_Mutation | c.1807N>G | p.Leu603Val | p.L603V | O15321 | protein_coding | tolerated(0.41) | benign(0.011) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
TM9SF1 | insertion | In_Frame_Ins | novel | c.505_506insGGCTGGAAAATTATCCATACAGATGTCTTCCGCTTCCCCCCATAC | p.Phe169delinsTrpLeuGluAsnTyrProTyrArgCysLeuProLeuProProIleLeu | p.F169delinsWLENYPYRCLPLPPIL | O15321 | protein_coding | TCGA-A2-A04X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
TM9SF1 | insertion | Nonsense_Mutation | novel | c.828_829insATAACAAAAAATTAGCCGGGCATGGTGGTTCACATCTGTAA | p.Ala277IlefsTer5 | p.A277Ifs*5 | O15321 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TM9SF1 | SNV | Missense_Mutation | novel | c.282N>C | p.Glu94Asp | p.E94D | O15321 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TM9SF1 | SNV | Missense_Mutation | c.1408N>C | p.Gly470Arg | p.G470R | O15321 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
TM9SF1 | SNV | Missense_Mutation | novel | c.1789N>T | p.Arg597Trp | p.R597W | O15321 | protein_coding | deleterious(0) | benign(0.43) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TM9SF1 | SNV | Missense_Mutation | novel | c.1337G>A | p.Arg446His | p.R446H | O15321 | protein_coding | deleterious(0.04) | probably_damaging(0.946) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TM9SF1 | SNV | Missense_Mutation | c.1144N>G | p.Leu382Val | p.L382V | O15321 | protein_coding | deleterious(0.03) | benign(0.377) | TCGA-AA-3530-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |