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Gene: TEAD3 |
Gene summary for TEAD3 |
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Gene information | Species | Human | Gene symbol | TEAD3 | Gene ID | 7005 |
Gene name | TEA domain transcription factor 3 | |
Gene Alias | DTEF-1 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q99594 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7005 | TEAD3 | ATC4 | Human | Thyroid | ATC | 8.10e-10 | 1.36e-01 | 0.34 |
7005 | TEAD3 | ATC5 | Human | Thyroid | ATC | 1.31e-33 | 6.36e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00353297 | Esophagus | ESCC | hippo signaling | 26/8552 | 40/18723 | 1.08e-02 | 3.66e-02 | 26 |
GO:0008356 | Esophagus | ESCC | asymmetric cell division | 14/8552 | 19/18723 | 1.27e-02 | 4.21e-02 | 14 |
GO:00075657 | Oral cavity | OSCC | female pregnancy | 98/7305 | 193/18723 | 5.66e-04 | 3.27e-03 | 98 |
GO:00447067 | Oral cavity | OSCC | multi-multicellular organism process | 105/7305 | 220/18723 | 5.05e-03 | 1.97e-02 | 105 |
GO:003532912 | Thyroid | PTC | hippo signaling | 24/5968 | 40/18723 | 2.27e-04 | 1.65e-03 | 24 |
GO:003532921 | Thyroid | ATC | hippo signaling | 24/6293 | 40/18723 | 5.54e-04 | 3.20e-03 | 24 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:000756517 | Thyroid | ATC | female pregnancy | 82/6293 | 193/18723 | 6.04e-03 | 2.42e-02 | 82 |
GO:00083561 | Thyroid | ATC | asymmetric cell division | 12/6293 | 19/18723 | 7.97e-03 | 3.08e-02 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEAD3 | SNV | Missense_Mutation | novel | c.430N>G | p.Phe144Val | p.F144V | Q99594 | protein_coding | tolerated(0.11) | benign(0) | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
TEAD3 | SNV | Missense_Mutation | rs773682085 | c.1297N>A | p.Val433Ile | p.V433I | Q99594 | protein_coding | tolerated(0.2) | benign(0) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEAD3 | SNV | Missense_Mutation | c.502C>G | p.Leu168Val | p.L168V | Q99594 | protein_coding | tolerated(0.31) | benign(0.017) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TEAD3 | insertion | Frame_Shift_Ins | novel | c.431_432insAGGGAAGAGGGAACCC | p.Phe144LeufsTer62 | p.F144Lfs*62 | Q99594 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TEAD3 | SNV | Missense_Mutation | c.332C>T | p.Ala111Val | p.A111V | Q99594 | protein_coding | tolerated(0.65) | possibly_damaging(0.787) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TEAD3 | SNV | Missense_Mutation | rs761773922 | c.1066N>A | p.Gly356Arg | p.G356R | Q99594 | protein_coding | deleterious(0) | possibly_damaging(0.836) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TEAD3 | SNV | Missense_Mutation | rs758902471 | c.1270N>A | p.Gly424Arg | p.G424R | Q99594 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TEAD3 | SNV | Missense_Mutation | c.478N>T | p.Arg160Trp | p.R160W | Q99594 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TEAD3 | SNV | Missense_Mutation | c.307N>T | p.Arg103Trp | p.R103W | Q99594 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TEAD3 | SNV | Missense_Mutation | c.134N>T | p.Glu45Val | p.E45V | Q99594 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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