![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TDP2 |
Gene summary for TDP2 |
![]() |
Gene information | Species | Human | Gene symbol | TDP2 | Gene ID | 51567 |
Gene name | tyrosyl-DNA phosphodiesterase 2 | |
Gene Alias | AD022 | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O95551 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51567 | TDP2 | C57 | Human | Oral cavity | OSCC | 2.01e-06 | 2.44e-01 | 0.1679 |
51567 | TDP2 | C06 | Human | Oral cavity | OSCC | 1.54e-03 | 9.39e-01 | 0.2699 |
51567 | TDP2 | C07 | Human | Oral cavity | OSCC | 2.27e-04 | 9.04e-01 | 0.2491 |
51567 | TDP2 | C08 | Human | Oral cavity | OSCC | 6.29e-25 | 5.72e-01 | 0.1919 |
51567 | TDP2 | C09 | Human | Oral cavity | OSCC | 1.38e-03 | 1.78e-01 | 0.1431 |
51567 | TDP2 | LN22 | Human | Oral cavity | OSCC | 1.91e-10 | 1.26e+00 | 0.1733 |
51567 | TDP2 | LN46 | Human | Oral cavity | OSCC | 1.29e-15 | 5.01e-01 | 0.1666 |
51567 | TDP2 | LP15 | Human | Oral cavity | LP | 9.64e-07 | 8.32e-01 | 0.2174 |
51567 | TDP2 | SYSMH1 | Human | Oral cavity | OSCC | 4.96e-08 | 2.34e-01 | 0.1127 |
51567 | TDP2 | SYSMH2 | Human | Oral cavity | OSCC | 1.02e-07 | 2.58e-01 | 0.2326 |
51567 | TDP2 | SYSMH3 | Human | Oral cavity | OSCC | 6.36e-08 | 2.90e-01 | 0.2442 |
51567 | TDP2 | SYSMH6 | Human | Oral cavity | OSCC | 3.07e-06 | 2.74e-01 | 0.1275 |
51567 | TDP2 | P2_cSCC | Human | Skin | cSCC | 2.13e-03 | 2.58e-01 | -0.024 |
51567 | TDP2 | P4_cSCC | Human | Skin | cSCC | 2.35e-08 | 2.86e-01 | -0.00290000000000005 |
51567 | TDP2 | P10_cSCC | Human | Skin | cSCC | 5.06e-21 | 6.56e-01 | 0.1017 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00063023 | Oral cavity | OSCC | double-strand break repair | 132/7305 | 251/18723 | 7.93e-06 | 8.52e-05 | 132 |
GO:00903051 | Oral cavity | LP | nucleic acid phosphodiester bond hydrolysis | 92/4623 | 261/18723 | 8.07e-05 | 1.04e-03 | 92 |
GO:000630211 | Oral cavity | LP | double-strand break repair | 80/4623 | 251/18723 | 5.81e-03 | 3.46e-02 | 80 |
GO:00903054 | Skin | cSCC | nucleic acid phosphodiester bond hydrolysis | 97/4864 | 261/18723 | 4.08e-05 | 4.34e-04 | 97 |
GO:00063025 | Skin | cSCC | double-strand break repair | 89/4864 | 251/18723 | 5.23e-04 | 3.92e-03 | 89 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TDP2 | SNV | Missense_Mutation | c.655N>C | p.Glu219Gln | p.E219Q | O95551 | protein_coding | tolerated(0.05) | benign(0.439) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
TDP2 | SNV | Missense_Mutation | c.272A>C | p.Glu91Ala | p.E91A | O95551 | protein_coding | tolerated(0.55) | benign(0.007) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TDP2 | SNV | Missense_Mutation | c.710N>A | p.Arg237Gln | p.R237Q | O95551 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TDP2 | SNV | Missense_Mutation | novel | c.995G>A | p.Arg332Gln | p.R332Q | O95551 | protein_coding | tolerated(1) | benign(0.007) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TDP2 | SNV | Missense_Mutation | novel | c.491G>T | p.Arg164Ile | p.R164I | O95551 | protein_coding | deleterious(0.04) | benign(0.392) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TDP2 | SNV | Missense_Mutation | c.85T>A | p.Cys29Ser | p.C29S | O95551 | protein_coding | deleterious(0.02) | benign(0.197) | TCGA-G5-6641-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TDP2 | deletion | Frame_Shift_Del | c.71delN | p.Lys24SerfsTer35 | p.K24Sfs*35 | O95551 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
TDP2 | SNV | Missense_Mutation | c.710N>T | p.Arg237Leu | p.R237L | O95551 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TDP2 | SNV | Missense_Mutation | c.796A>G | p.Arg266Gly | p.R266G | O95551 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
TDP2 | SNV | Missense_Mutation | rs745911675 | c.940N>T | p.Arg314Cys | p.R314C | O95551 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51567 | TDP2 | ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | 9,10-PHENANTHRENEQUINONE | 9,10-PHENANTHRENEQUINONE | ||
51567 | TDP2 | ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | GNF-PF-4418 | CHEMBL604321 | ||
51567 | TDP2 | ENZYME, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | (-)-DICENTRINE | CHEMBL478754 |
Page: 1 |