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Gene: TCEB1 |
Gene summary for TCEB1 |
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Gene information | Species | Human | Gene symbol | TCEB1 | Gene ID | 6921 |
Gene name | elongin C | |
Gene Alias | SIII | |
Cytomap | 8q21.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R7Y5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6921 | TCEB1 | P91T-E | Human | Esophagus | ESCC | 1.81e-22 | 2.95e+00 | 0.1828 |
6921 | TCEB1 | P107T-E | Human | Esophagus | ESCC | 3.93e-65 | 2.23e+00 | 0.171 |
6921 | TCEB1 | P126T-E | Human | Esophagus | ESCC | 5.21e-15 | 1.89e+00 | 0.1125 |
6921 | TCEB1 | P127T-E | Human | Esophagus | ESCC | 1.51e-18 | 4.99e-01 | 0.0826 |
6921 | TCEB1 | P128T-E | Human | Esophagus | ESCC | 5.76e-54 | 2.69e+00 | 0.1241 |
6921 | TCEB1 | P130T-E | Human | Esophagus | ESCC | 1.10e-69 | 1.86e+00 | 0.1676 |
6921 | TCEB1 | S41 | Human | Liver | Cirrhotic | 2.87e-02 | -5.37e-01 | -0.0343 |
6921 | TCEB1 | S43 | Human | Liver | Cirrhotic | 8.58e-19 | -5.37e-01 | -0.0187 |
6921 | TCEB1 | HCC1_Meng | Human | Liver | HCC | 1.05e-61 | 6.95e-01 | 0.0246 |
6921 | TCEB1 | HCC2_Meng | Human | Liver | HCC | 1.05e-53 | 9.41e-02 | 0.0107 |
6921 | TCEB1 | cirrhotic1 | Human | Liver | Cirrhotic | 7.14e-26 | 1.50e-01 | 0.0202 |
6921 | TCEB1 | cirrhotic2 | Human | Liver | Cirrhotic | 1.43e-28 | 5.76e-02 | 0.0201 |
6921 | TCEB1 | cirrhotic3 | Human | Liver | Cirrhotic | 3.96e-21 | 1.47e-01 | 0.0215 |
6921 | TCEB1 | p6 | Human | Liver | Cyst | 2.87e-02 | -5.37e-01 | -0.0218 |
6921 | TCEB1 | HCC1 | Human | Liver | HCC | 1.19e-03 | -5.37e-01 | 0.5336 |
6921 | TCEB1 | HCC2 | Human | Liver | HCC | 1.00e-05 | -5.37e-01 | 0.5341 |
6921 | TCEB1 | HCC5 | Human | Liver | HCC | 8.37e-09 | -5.37e-01 | 0.4932 |
6921 | TCEB1 | Pt13.a | Human | Liver | HCC | 1.63e-14 | 4.62e-01 | 0.021 |
6921 | TCEB1 | Pt13.b | Human | Liver | HCC | 5.01e-49 | 5.88e-01 | 0.0251 |
6921 | TCEB1 | Pt14.a | Human | Liver | HCC | 9.46e-06 | 2.24e-01 | 0.0169 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0406616 | Breast | Precancer | HIF-1 signaling pathway | 23/684 | 109/8465 | 1.51e-05 | 1.59e-04 | 1.22e-04 | 23 |
hsa0406617 | Breast | Precancer | HIF-1 signaling pathway | 23/684 | 109/8465 | 1.51e-05 | 1.59e-04 | 1.22e-04 | 23 |
hsa0406623 | Breast | IDC | HIF-1 signaling pathway | 22/867 | 109/8465 | 1.36e-03 | 1.00e-02 | 7.50e-03 | 22 |
hsa052118 | Breast | IDC | Renal cell carcinoma | 14/867 | 69/8465 | 9.16e-03 | 4.37e-02 | 3.27e-02 | 14 |
hsa0517014 | Breast | IDC | Human immunodeficiency virus 1 infection | 33/867 | 212/8465 | 9.28e-03 | 4.37e-02 | 3.27e-02 | 33 |
hsa0406633 | Breast | IDC | HIF-1 signaling pathway | 22/867 | 109/8465 | 1.36e-03 | 1.00e-02 | 7.50e-03 | 22 |
hsa0521113 | Breast | IDC | Renal cell carcinoma | 14/867 | 69/8465 | 9.16e-03 | 4.37e-02 | 3.27e-02 | 14 |
hsa0517015 | Breast | IDC | Human immunodeficiency virus 1 infection | 33/867 | 212/8465 | 9.28e-03 | 4.37e-02 | 3.27e-02 | 33 |
hsa0406642 | Breast | DCIS | HIF-1 signaling pathway | 22/846 | 109/8465 | 9.83e-04 | 7.05e-03 | 5.20e-03 | 22 |
hsa0517024 | Breast | DCIS | Human immunodeficiency virus 1 infection | 33/846 | 212/8465 | 6.49e-03 | 3.22e-02 | 2.37e-02 | 33 |
hsa0521123 | Breast | DCIS | Renal cell carcinoma | 14/846 | 69/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 14 |
hsa0406652 | Breast | DCIS | HIF-1 signaling pathway | 22/846 | 109/8465 | 9.83e-04 | 7.05e-03 | 5.20e-03 | 22 |
hsa0517034 | Breast | DCIS | Human immunodeficiency virus 1 infection | 33/846 | 212/8465 | 6.49e-03 | 3.22e-02 | 2.37e-02 | 33 |
hsa0521133 | Breast | DCIS | Renal cell carcinoma | 14/846 | 69/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 14 |
hsa0412016 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa0406620 | Endometrium | AEH | HIF-1 signaling pathway | 29/1197 | 109/8465 | 4.23e-04 | 3.11e-03 | 2.27e-03 | 29 |
hsa0517018 | Endometrium | AEH | Human immunodeficiency virus 1 infection | 43/1197 | 212/8465 | 8.19e-03 | 4.22e-02 | 3.09e-02 | 43 |
hsa0412017 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa04066110 | Endometrium | AEH | HIF-1 signaling pathway | 29/1197 | 109/8465 | 4.23e-04 | 3.11e-03 | 2.27e-03 | 29 |
hsa0517019 | Endometrium | AEH | Human immunodeficiency virus 1 infection | 43/1197 | 212/8465 | 8.19e-03 | 4.22e-02 | 3.09e-02 | 43 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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