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Gene: STRAP |
Gene summary for STRAP |
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Gene information | Species | Human | Gene symbol | STRAP | Gene ID | 11171 |
Gene name | serine/threonine kinase receptor associated protein | |
Gene Alias | MAWD | |
Cytomap | 12p12.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9Y3F4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11171 | STRAP | P84T-E | Human | Esophagus | ESCC | 4.28e-12 | 1.40e+00 | 0.0933 |
11171 | STRAP | P89T-E | Human | Esophagus | ESCC | 1.12e-18 | 2.33e+00 | 0.1752 |
11171 | STRAP | P91T-E | Human | Esophagus | ESCC | 5.94e-22 | 2.39e+00 | 0.1828 |
11171 | STRAP | P107T-E | Human | Esophagus | ESCC | 6.59e-53 | 2.03e+00 | 0.171 |
11171 | STRAP | P126T-E | Human | Esophagus | ESCC | 6.39e-04 | 1.11e+00 | 0.1125 |
11171 | STRAP | P127T-E | Human | Esophagus | ESCC | 9.27e-44 | 8.98e-01 | 0.0826 |
11171 | STRAP | P128T-E | Human | Esophagus | ESCC | 9.50e-33 | 1.52e+00 | 0.1241 |
11171 | STRAP | P130T-E | Human | Esophagus | ESCC | 9.28e-77 | 2.61e+00 | 0.1676 |
11171 | STRAP | S43 | Human | Liver | Cirrhotic | 1.37e-06 | -2.38e-01 | -0.0187 |
11171 | STRAP | HCC1_Meng | Human | Liver | HCC | 2.73e-63 | 1.02e-01 | 0.0246 |
11171 | STRAP | HCC2_Meng | Human | Liver | HCC | 4.08e-27 | 4.53e-02 | 0.0107 |
11171 | STRAP | cirrhotic2 | Human | Liver | Cirrhotic | 9.19e-09 | 1.54e-01 | 0.0201 |
11171 | STRAP | HCC1 | Human | Liver | HCC | 7.31e-06 | 3.56e+00 | 0.5336 |
11171 | STRAP | HCC2 | Human | Liver | HCC | 1.11e-07 | 2.78e+00 | 0.5341 |
11171 | STRAP | Pt13.b | Human | Liver | HCC | 6.89e-35 | 3.92e-01 | 0.0251 |
11171 | STRAP | Pt14.a | Human | Liver | HCC | 7.31e-06 | 2.01e-01 | 0.0169 |
11171 | STRAP | Pt14.b | Human | Liver | HCC | 8.97e-04 | 2.05e-01 | 0.018 |
11171 | STRAP | S014 | Human | Liver | HCC | 3.93e-43 | 1.67e+00 | 0.2254 |
11171 | STRAP | S015 | Human | Liver | HCC | 1.60e-36 | 1.93e+00 | 0.2375 |
11171 | STRAP | S016 | Human | Liver | HCC | 2.15e-40 | 1.81e+00 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0000380 | Colorectum | AD | alternative mRNA splicing, via spliceosome | 33/3918 | 77/18723 | 1.13e-05 | 2.55e-04 | 33 |
GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0071559 | Colorectum | AD | response to transforming growth factor beta | 74/3918 | 256/18723 | 1.45e-03 | 1.23e-02 | 74 |
GO:0071560 | Colorectum | AD | cellular response to transforming growth factor beta stimulus | 72/3918 | 250/18723 | 1.85e-03 | 1.52e-02 | 72 |
GO:0007179 | Colorectum | AD | transforming growth factor beta receptor signaling pathway | 59/3918 | 198/18723 | 1.94e-03 | 1.58e-02 | 59 |
GO:0030277 | Colorectum | AD | maintenance of gastrointestinal epithelium | 10/3918 | 22/18723 | 8.52e-03 | 4.97e-02 | 10 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00718262 | Colorectum | MSS | ribonucleoprotein complex subunit organization | 90/3467 | 227/18723 | 6.88e-14 | 1.78e-11 | 90 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STRAP | SNV | Missense_Mutation | c.996A>T | p.Glu332Asp | p.E332D | Q9Y3F4 | protein_coding | tolerated_low_confidence(0.35) | benign(0) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STRAP | insertion | Nonsense_Mutation | novel | c.821_822insATCAAATGAAGTCTGTGAGGGATATTAGAGATAAAGGAGAT | p.Ser274ArgfsTer10 | p.S274Rfs*10 | Q9Y3F4 | protein_coding | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
STRAP | SNV | Missense_Mutation | novel | c.397N>A | p.Glu133Lys | p.E133K | Q9Y3F4 | protein_coding | deleterious(0.04) | benign(0.164) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STRAP | SNV | Missense_Mutation | rs185224819 | c.724N>A | p.Gly242Ser | p.G242S | Q9Y3F4 | protein_coding | tolerated(0.06) | benign(0.397) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STRAP | SNV | Missense_Mutation | c.853N>C | p.Glu285Gln | p.E285Q | Q9Y3F4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
STRAP | SNV | Missense_Mutation | c.130N>T | p.Arg44Cys | p.R44C | Q9Y3F4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
STRAP | SNV | Missense_Mutation | c.49G>A | p.Val17Met | p.V17M | Q9Y3F4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STRAP | SNV | Missense_Mutation | novel | c.562N>C | p.Ser188Arg | p.S188R | Q9Y3F4 | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
STRAP | SNV | Missense_Mutation | novel | c.910N>G | p.Lys304Glu | p.K304E | Q9Y3F4 | protein_coding | deleterious(0.01) | possibly_damaging(0.51) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
STRAP | SNV | Missense_Mutation | rs752651730 | c.374G>A | p.Arg125His | p.R125H | Q9Y3F4 | protein_coding | deleterious(0.03) | benign(0.303) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11171 | STRAP | KINASE | ADJUVANT | 15720808 |
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