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Gene: SSBP2 |
Gene summary for SSBP2 |
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Gene information | Species | Human | Gene symbol | SSBP2 | Gene ID | 23635 |
Gene name | single stranded DNA binding protein 2 | |
Gene Alias | HSPC116 | |
Cytomap | 5q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087X159 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23635 | SSBP2 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 5.07e-04 | 6.88e-01 | -0.0961 |
23635 | SSBP2 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 5.03e-03 | 6.21e-01 | -0.0876 |
23635 | SSBP2 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 8.89e-03 | 6.15e-01 | -0.0822 |
23635 | SSBP2 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.47e-05 | 7.28e-01 | -0.0809 |
23635 | SSBP2 | C38 | Human | Oral cavity | OSCC | 4.98e-03 | 4.16e-01 | 0.172 |
23635 | SSBP2 | C43 | Human | Oral cavity | OSCC | 3.25e-19 | 4.52e-01 | 0.1704 |
23635 | SSBP2 | C46 | Human | Oral cavity | OSCC | 2.07e-13 | 4.57e-01 | 0.1673 |
23635 | SSBP2 | C08 | Human | Oral cavity | OSCC | 3.66e-08 | 3.03e-01 | 0.1919 |
23635 | SSBP2 | C09 | Human | Oral cavity | OSCC | 8.76e-31 | 1.16e+00 | 0.1431 |
23635 | SSBP2 | EOLP-1 | Human | Oral cavity | EOLP | 1.19e-19 | 6.38e-01 | -0.0202 |
23635 | SSBP2 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.63e-21 | 6.68e-01 | -0.0194 |
23635 | SSBP2 | NEOLP-2 | Human | Oral cavity | NEOLP | 2.43e-12 | 5.19e-01 | -0.0196 |
23635 | SSBP2 | NEOLP-3 | Human | Oral cavity | NEOLP | 2.80e-17 | 5.79e-01 | -0.0191 |
23635 | SSBP2 | SYSMH1 | Human | Oral cavity | OSCC | 2.20e-05 | -6.84e-02 | 0.1127 |
23635 | SSBP2 | SYSMH3 | Human | Oral cavity | OSCC | 2.50e-05 | -3.20e-01 | 0.2442 |
23635 | SSBP2 | SYSMH4 | Human | Oral cavity | OSCC | 5.21e-05 | -1.41e-01 | 0.1226 |
23635 | SSBP2 | SYSMH5 | Human | Oral cavity | OSCC | 5.35e-07 | -3.86e-01 | 0.0647 |
23635 | SSBP2 | HTA12-15-2 | Human | Pancreas | PDAC | 3.39e-13 | 8.49e-01 | 0.2315 |
23635 | SSBP2 | HTA12-23-1 | Human | Pancreas | PDAC | 1.72e-13 | 1.09e+00 | 0.3405 |
23635 | SSBP2 | HTA12-25-1 | Human | Pancreas | PDAC | 2.05e-13 | 8.84e-01 | 0.313 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSBP2 | SNV | Missense_Mutation | novel | c.1071N>C | p.Gln357His | p.Q357H | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.978) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
SSBP2 | SNV | Missense_Mutation | c.408N>C | p.Arg136Ser | p.R136S | protein_coding | deleterious(0.03) | benign(0.105) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | novel | c.866N>T | p.Arg289Ile | p.R289I | protein_coding | deleterious(0.01) | probably_damaging(0.929) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP2 | SNV | Missense_Mutation | novel | c.530N>T | p.Arg177Ile | p.R177I | protein_coding | deleterious(0.03) | probably_damaging(0.978) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP2 | SNV | Missense_Mutation | c.882N>T | p.Met294Ile | p.M294I | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
SSBP2 | deletion | Frame_Shift_Del | novel | c.626delN | p.Asn209MetfsTer3 | p.N209Mfs*3 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
SSBP2 | SNV | Missense_Mutation | c.890N>T | p.Gly297Val | p.G297V | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | c.752N>T | p.Pro251Leu | p.P251L | protein_coding | deleterious(0.03) | possibly_damaging(0.477) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | c.76N>A | p.Val26Ile | p.V26I | protein_coding | tolerated(0.05) | possibly_damaging(0.682) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SSBP2 | SNV | Missense_Mutation | c.984N>G | p.Asn328Lys | p.N328K | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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