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Gene: SRSF2 |
Gene summary for SRSF2 |
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Gene information | Species | Human | Gene symbol | SRSF2 | Gene ID | 6427 |
Gene name | serine and arginine rich splicing factor 2 | |
Gene Alias | PR264 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A024R8U5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6427 | SRSF2 | P12T-E | Human | Esophagus | ESCC | 3.54e-54 | 1.88e+00 | 0.1122 |
6427 | SRSF2 | P15T-E | Human | Esophagus | ESCC | 4.90e-48 | 1.70e+00 | 0.1149 |
6427 | SRSF2 | P16T-E | Human | Esophagus | ESCC | 1.62e-48 | 1.50e+00 | 0.1153 |
6427 | SRSF2 | P17T-E | Human | Esophagus | ESCC | 2.56e-13 | 1.30e+00 | 0.1278 |
6427 | SRSF2 | P19T-E | Human | Esophagus | ESCC | 4.88e-05 | 1.14e+00 | 0.1662 |
6427 | SRSF2 | P20T-E | Human | Esophagus | ESCC | 1.19e-68 | 3.17e+00 | 0.1124 |
6427 | SRSF2 | P21T-E | Human | Esophagus | ESCC | 6.92e-64 | 2.00e+00 | 0.1617 |
6427 | SRSF2 | P22T-E | Human | Esophagus | ESCC | 1.01e-40 | 1.21e+00 | 0.1236 |
6427 | SRSF2 | P23T-E | Human | Esophagus | ESCC | 2.16e-27 | 1.21e+00 | 0.108 |
6427 | SRSF2 | P24T-E | Human | Esophagus | ESCC | 7.27e-34 | 1.32e+00 | 0.1287 |
6427 | SRSF2 | P26T-E | Human | Esophagus | ESCC | 1.45e-55 | 1.94e+00 | 0.1276 |
6427 | SRSF2 | P27T-E | Human | Esophagus | ESCC | 4.83e-55 | 1.87e+00 | 0.1055 |
6427 | SRSF2 | P28T-E | Human | Esophagus | ESCC | 5.74e-62 | 2.03e+00 | 0.1149 |
6427 | SRSF2 | P30T-E | Human | Esophagus | ESCC | 2.01e-43 | 2.64e+00 | 0.137 |
6427 | SRSF2 | P31T-E | Human | Esophagus | ESCC | 1.24e-50 | 1.51e+00 | 0.1251 |
6427 | SRSF2 | P32T-E | Human | Esophagus | ESCC | 8.96e-63 | 2.07e+00 | 0.1666 |
6427 | SRSF2 | P36T-E | Human | Esophagus | ESCC | 3.56e-31 | 1.83e+00 | 0.1187 |
6427 | SRSF2 | P37T-E | Human | Esophagus | ESCC | 9.14e-23 | 1.09e+00 | 0.1371 |
6427 | SRSF2 | P39T-E | Human | Esophagus | ESCC | 2.56e-28 | 1.23e+00 | 0.0894 |
6427 | SRSF2 | P40T-E | Human | Esophagus | ESCC | 3.16e-15 | 1.20e+00 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00480249 | Breast | Precancer | regulation of mRNA splicing, via spliceosome | 22/1080 | 101/18723 | 5.29e-08 | 3.18e-06 | 22 |
GO:19033118 | Breast | Precancer | regulation of mRNA metabolic process | 38/1080 | 288/18723 | 1.63e-06 | 5.97e-05 | 38 |
GO:00506848 | Breast | Precancer | regulation of mRNA processing | 23/1080 | 137/18723 | 3.49e-06 | 1.13e-04 | 23 |
GO:00003808 | Breast | Precancer | alternative mRNA splicing, via spliceosome | 15/1080 | 77/18723 | 2.86e-05 | 6.37e-04 | 15 |
GO:00003818 | Breast | Precancer | regulation of alternative mRNA splicing, via spliceosome | 13/1080 | 60/18723 | 2.98e-05 | 6.58e-04 | 13 |
GO:00316679 | Breast | Precancer | response to nutrient levels | 47/1080 | 474/18723 | 2.09e-04 | 3.27e-03 | 47 |
GO:00075845 | Breast | Precancer | response to nutrient | 19/1080 | 174/18723 | 5.63e-03 | 4.08e-02 | 19 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:004802414 | Breast | IDC | regulation of mRNA splicing, via spliceosome | 23/1434 | 101/18723 | 1.74e-06 | 7.28e-05 | 23 |
GO:003166714 | Breast | IDC | response to nutrient levels | 62/1434 | 474/18723 | 2.33e-05 | 5.57e-04 | 62 |
GO:000758412 | Breast | IDC | response to nutrient | 29/1434 | 174/18723 | 5.69e-05 | 1.20e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRSF2 | SNV | Missense_Mutation | novel | c.156N>C | p.Lys52Asn | p.K52N | Q01130 | protein_coding | tolerated(0.06) | benign(0.243) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
SRSF2 | SNV | Missense_Mutation | c.407C>G | p.Ser136Cys | p.S136C | Q01130 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
SRSF2 | SNV | Missense_Mutation | c.205N>A | p.Glu69Lys | p.E69K | Q01130 | protein_coding | deleterious(0.05) | possibly_damaging(0.64) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
SRSF2 | SNV | Missense_Mutation | c.205G>A | p.Glu69Lys | p.E69K | Q01130 | protein_coding | deleterious(0.05) | possibly_damaging(0.64) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SRSF2 | SNV | Missense_Mutation | c.311G>A | p.Gly104Glu | p.G104E | Q01130 | protein_coding | tolerated(0.5) | benign(0.346) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SRSF2 | SNV | Missense_Mutation | c.143N>G | p.Asp48Gly | p.D48G | Q01130 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SRSF2 | SNV | Missense_Mutation | novel | c.560N>A | p.Ser187Tyr | p.S187Y | Q01130 | protein_coding | deleterious(0.02) | benign(0.166) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SRSF2 | SNV | Missense_Mutation | rs755334722 | c.425N>T | p.Ser142Phe | p.S142F | Q01130 | protein_coding | deleterious(0.03) | possibly_damaging(0.601) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SRSF2 | SNV | Missense_Mutation | novel | c.470N>A | p.Ser157Tyr | p.S157Y | Q01130 | protein_coding | deleterious(0) | benign(0.332) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SRSF2 | SNV | Missense_Mutation | novel | c.631A>G | p.Lys211Glu | p.K211E | Q01130 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6427 | SRSF2 | CLINICALLY ACTIONABLE | H3B-8800 | |||
6427 | SRSF2 | CLINICALLY ACTIONABLE | N/A | 26508027,26769228 |
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