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Gene: SRSF11 |
Gene summary for SRSF11 |
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Gene information | Species | Human | Gene symbol | SRSF11 | Gene ID | 9295 |
Gene name | serine and arginine rich splicing factor 11 | |
Gene Alias | NET2 | |
Cytomap | 1p31.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q05519 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9295 | SRSF11 | P23T-E | Human | Esophagus | ESCC | 1.25e-44 | 1.33e+00 | 0.108 |
9295 | SRSF11 | P24T-E | Human | Esophagus | ESCC | 4.26e-30 | 7.98e-01 | 0.1287 |
9295 | SRSF11 | P26T-E | Human | Esophagus | ESCC | 1.24e-43 | 9.84e-01 | 0.1276 |
9295 | SRSF11 | P27T-E | Human | Esophagus | ESCC | 5.63e-64 | 1.35e+00 | 0.1055 |
9295 | SRSF11 | P28T-E | Human | Esophagus | ESCC | 2.69e-48 | 1.18e+00 | 0.1149 |
9295 | SRSF11 | P30T-E | Human | Esophagus | ESCC | 1.66e-35 | 1.64e+00 | 0.137 |
9295 | SRSF11 | P31T-E | Human | Esophagus | ESCC | 3.27e-67 | 1.38e+00 | 0.1251 |
9295 | SRSF11 | P32T-E | Human | Esophagus | ESCC | 5.90e-51 | 1.22e+00 | 0.1666 |
9295 | SRSF11 | P36T-E | Human | Esophagus | ESCC | 1.21e-27 | 1.16e+00 | 0.1187 |
9295 | SRSF11 | P37T-E | Human | Esophagus | ESCC | 6.21e-39 | 1.04e+00 | 0.1371 |
9295 | SRSF11 | P39T-E | Human | Esophagus | ESCC | 2.79e-52 | 1.33e+00 | 0.0894 |
9295 | SRSF11 | P40T-E | Human | Esophagus | ESCC | 3.05e-14 | 6.09e-01 | 0.109 |
9295 | SRSF11 | P42T-E | Human | Esophagus | ESCC | 1.79e-34 | 1.19e+00 | 0.1175 |
9295 | SRSF11 | P44T-E | Human | Esophagus | ESCC | 1.22e-19 | 7.01e-01 | 0.1096 |
9295 | SRSF11 | P47T-E | Human | Esophagus | ESCC | 7.97e-22 | 5.37e-01 | 0.1067 |
9295 | SRSF11 | P48T-E | Human | Esophagus | ESCC | 1.16e-32 | 8.53e-01 | 0.0959 |
9295 | SRSF11 | P49T-E | Human | Esophagus | ESCC | 7.05e-16 | 2.08e+00 | 0.1768 |
9295 | SRSF11 | P52T-E | Human | Esophagus | ESCC | 3.26e-53 | 1.38e+00 | 0.1555 |
9295 | SRSF11 | P54T-E | Human | Esophagus | ESCC | 8.79e-40 | 1.17e+00 | 0.0975 |
9295 | SRSF11 | P56T-E | Human | Esophagus | ESCC | 6.90e-18 | 2.16e+00 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00083805 | Colorectum | CRC | RNA splicing | 90/2078 | 434/18723 | 2.80e-09 | 7.97e-07 | 90 |
GO:000838016 | Endometrium | AEH | RNA splicing | 111/2100 | 434/18723 | 2.42e-17 | 1.12e-14 | 111 |
GO:000838017 | Endometrium | EEC | RNA splicing | 111/2168 | 434/18723 | 2.45e-16 | 1.13e-13 | 111 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:00083808 | Lung | IAC | RNA splicing | 75/2061 | 434/18723 | 4.89e-05 | 1.12e-03 | 75 |
GO:000838013 | Lung | AIS | RNA splicing | 68/1849 | 434/18723 | 8.50e-05 | 2.11e-03 | 68 |
GO:000838023 | Lung | MIAC | RNA splicing | 44/967 | 434/18723 | 1.56e-05 | 1.07e-03 | 44 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:000838025 | Oral cavity | EOLP | RNA splicing | 115/2218 | 434/18723 | 2.24e-17 | 3.04e-14 | 115 |
GO:000838033 | Oral cavity | NEOLP | RNA splicing | 110/2005 | 434/18723 | 2.29e-18 | 2.72e-15 | 110 |
GO:000838018 | Prostate | BPH | RNA splicing | 147/3107 | 434/18723 | 5.17e-19 | 2.29e-16 | 147 |
GO:000838019 | Prostate | Tumor | RNA splicing | 153/3246 | 434/18723 | 9.15e-20 | 5.79e-17 | 153 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRSF11 | SNV | Missense_Mutation | c.1441N>A | p.Asp481Asn | p.D481N | Q05519 | protein_coding | deleterious_low_confidence(0) | benign(0.307) | TCGA-A2-A0SW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | PD | |
SRSF11 | SNV | Missense_Mutation | c.511N>C | p.Gly171Arg | p.G171R | Q05519 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-AR-A0TZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Doxorubicin | PD | |
SRSF11 | SNV | Missense_Mutation | c.275N>T | p.Ala92Val | p.A92V | Q05519 | protein_coding | deleterious(0) | possibly_damaging(0.687) | TCGA-BH-A0E9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
SRSF11 | SNV | Missense_Mutation | c.965N>C | p.Arg322Pro | p.R322P | Q05519 | protein_coding | deleterious(0.01) | possibly_damaging(0.769) | TCGA-D8-A1JF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SRSF11 | SNV | Missense_Mutation | c.553N>A | p.Asp185Asn | p.D185N | Q05519 | protein_coding | deleterious(0.04) | possibly_damaging(0.681) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
SRSF11 | insertion | Frame_Shift_Ins | novel | c.115_116insCTTTTGC | p.Asn39ThrfsTer9 | p.N39Tfs*9 | Q05519 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
SRSF11 | insertion | Nonsense_Mutation | novel | c.116_117insGGAGGATGAATGCTTTTTTTAAAAAAAAAGTTTATACG | p.Asn39LysfsTer8 | p.N39Kfs*8 | Q05519 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
SRSF11 | SNV | Missense_Mutation | novel | c.1342G>A | p.Gly448Ser | p.G448S | Q05519 | protein_coding | tolerated_low_confidence(0.7) | benign(0.023) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SRSF11 | SNV | Missense_Mutation | novel | c.1147N>A | p.Asp383Asn | p.D383N | Q05519 | protein_coding | deleterious(0.02) | benign(0.07) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SRSF11 | SNV | Missense_Mutation | c.823N>T | p.Arg275Trp | p.R275W | Q05519 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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