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Gene: SMARCA1 |
Gene summary for SMARCA1 |
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Gene information | Species | Human | Gene symbol | SMARCA1 | Gene ID | 6594 |
Gene name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | |
Gene Alias | ISWI | |
Cytomap | Xq25-q26.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B7ZLQ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6594 | SMARCA1 | PTC04 | Human | Thyroid | PTC | 1.61e-14 | 4.74e-01 | 0.1927 |
6594 | SMARCA1 | PTC05 | Human | Thyroid | PTC | 4.15e-18 | 7.16e-01 | 0.2065 |
6594 | SMARCA1 | PTC06 | Human | Thyroid | PTC | 3.87e-20 | 6.18e-01 | 0.2057 |
6594 | SMARCA1 | PTC07 | Human | Thyroid | PTC | 1.61e-34 | 6.19e-01 | 0.2044 |
6594 | SMARCA1 | ATC09 | Human | Thyroid | ATC | 3.36e-04 | 1.28e-01 | 0.2871 |
6594 | SMARCA1 | ATC12 | Human | Thyroid | ATC | 9.90e-15 | 5.25e-01 | 0.34 |
6594 | SMARCA1 | ATC13 | Human | Thyroid | ATC | 3.78e-44 | 1.00e+00 | 0.34 |
6594 | SMARCA1 | ATC1 | Human | Thyroid | ATC | 3.98e-05 | 1.86e-01 | 0.2878 |
6594 | SMARCA1 | ATC2 | Human | Thyroid | ATC | 3.38e-08 | 1.79e+00 | 0.34 |
6594 | SMARCA1 | ATC3 | Human | Thyroid | ATC | 3.75e-02 | 6.64e-01 | 0.338 |
6594 | SMARCA1 | ATC4 | Human | Thyroid | ATC | 1.67e-20 | 7.32e-01 | 0.34 |
6594 | SMARCA1 | ATC5 | Human | Thyroid | ATC | 1.54e-42 | 1.10e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:00063259 | Prostate | BPH | chromatin organization | 101/3107 | 409/18723 | 1.52e-05 | 1.94e-04 | 101 |
GO:00063382 | Prostate | BPH | chromatin remodeling | 62/3107 | 255/18723 | 9.47e-04 | 5.97e-03 | 62 |
GO:000632514 | Prostate | Tumor | chromatin organization | 104/3246 | 409/18723 | 2.02e-05 | 2.62e-04 | 104 |
GO:000633811 | Prostate | Tumor | chromatin remodeling | 63/3246 | 255/18723 | 1.73e-03 | 1.02e-02 | 63 |
GO:000632519 | Skin | cSCC | chromatin organization | 147/4864 | 409/18723 | 4.41e-06 | 6.52e-05 | 147 |
GO:000633812 | Skin | cSCC | chromatin remodeling | 94/4864 | 255/18723 | 7.58e-05 | 7.26e-04 | 94 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:000633813 | Thyroid | ATC | chromatin remodeling | 109/6293 | 255/18723 | 1.38e-03 | 7.15e-03 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
SMARCA1 | ISLET | Pancreas | PDAC | OCRL,SSX2IP,DMD, etc. | 1.24e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMARCA1 | SNV | Missense_Mutation | c.1384N>G | p.His462Asp | p.H462D | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-A2-A0SY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | ||
SMARCA1 | SNV | Missense_Mutation | c.1455N>A | p.Ser485Arg | p.S485R | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-A2-A1FX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | ||
SMARCA1 | SNV | Missense_Mutation | novel | c.2282N>A | p.Ala761Asp | p.A761D | protein_coding | tolerated(0.55) | possibly_damaging(0.716) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
SMARCA1 | SNV | Missense_Mutation | c.962N>A | p.Ser321Tyr | p.S321Y | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | ||
SMARCA1 | SNV | Missense_Mutation | c.2665G>T | p.Gly889Cys | p.G889C | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A7-A26H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD | ||
SMARCA1 | SNV | Missense_Mutation | novel | c.1572N>C | p.Trp524Cys | p.W524C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SMARCA1 | SNV | Missense_Mutation | c.213A>T | p.Lys71Asn | p.K71N | protein_coding | tolerated(0.44) | benign(0.187) | TCGA-BH-A0E9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | ||
SMARCA1 | SNV | Missense_Mutation | c.2542N>C | p.Glu848Gln | p.E848Q | protein_coding | tolerated(0.11) | benign(0.301) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SMARCA1 | SNV | Missense_Mutation | c.1319N>T | p.Ser440Phe | p.S440F | protein_coding | deleterious(0) | possibly_damaging(0.811) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | ||
SMARCA1 | SNV | Missense_Mutation | c.433N>T | p.Arg145Cys | p.R145C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1RB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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