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Gene: SLC25A26 |
Gene summary for SLC25A26 |
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Gene information | Species | Human | Gene symbol | SLC25A26 | Gene ID | 115286 |
Gene name | solute carrier family 25 member 26 | |
Gene Alias | COXPD28 | |
Cytomap | 3p14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q70HW3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115286 | SLC25A26 | C09 | Human | Oral cavity | OSCC | 2.68e-07 | 3.35e-01 | 0.1431 |
115286 | SLC25A26 | LN22 | Human | Oral cavity | OSCC | 6.17e-04 | 8.90e-01 | 0.1733 |
115286 | SLC25A26 | LN46 | Human | Oral cavity | OSCC | 9.36e-16 | 7.14e-01 | 0.1666 |
115286 | SLC25A26 | LP15 | Human | Oral cavity | LP | 7.88e-04 | 6.77e-01 | 0.2174 |
115286 | SLC25A26 | SYSMH2 | Human | Oral cavity | OSCC | 2.06e-06 | 2.68e-01 | 0.2326 |
115286 | SLC25A26 | SYSMH3 | Human | Oral cavity | OSCC | 1.41e-06 | 2.59e-01 | 0.2442 |
115286 | SLC25A26 | SYSMH4 | Human | Oral cavity | OSCC | 7.52e-03 | 8.39e-02 | 0.1226 |
115286 | SLC25A26 | P4_S8_cSCC | Human | Skin | cSCC | 4.63e-08 | 2.19e-01 | -0.3095 |
115286 | SLC25A26 | P1_cSCC | Human | Skin | cSCC | 1.29e-17 | 6.86e-01 | 0.0292 |
115286 | SLC25A26 | P2_cSCC | Human | Skin | cSCC | 1.29e-09 | 3.85e-01 | -0.024 |
115286 | SLC25A26 | P4_cSCC | Human | Skin | cSCC | 2.47e-11 | 4.05e-01 | -0.00290000000000005 |
115286 | SLC25A26 | P10_cSCC | Human | Skin | cSCC | 5.92e-11 | 4.85e-01 | 0.1017 |
115286 | SLC25A26 | cSCC_p8 | Human | Skin | cSCC | 1.55e-02 | 8.09e-02 | -0.1971 |
115286 | SLC25A26 | cSCC_p9 | Human | Skin | cSCC | 1.00e-04 | 1.43e-01 | -0.1991 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A26 | deletion | Frame_Shift_Del | novel | c.199delN | p.Phe68LeufsTer7 | p.F68Lfs*7 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
SLC25A26 | SNV | Missense_Mutation | c.494N>C | p.Leu165Ser | p.L165S | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
SLC25A26 | deletion | Frame_Shift_Del | novel | c.199delN | p.Phe68LeufsTer7 | p.F68Lfs*7 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SLC25A26 | deletion | Frame_Shift_Del | c.247_248delNN | p.Ser83PhefsTer27 | p.S83Ffs*27 | protein_coding | TCGA-AG-A01W-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||||
SLC25A26 | SNV | Missense_Mutation | novel | c.274N>G | p.Met92Val | p.M92V | protein_coding | deleterious(0.04) | possibly_damaging(0.614) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC25A26 | SNV | Missense_Mutation | novel | c.176N>T | p.Gly59Val | p.G59V | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC25A26 | SNV | Missense_Mutation | novel | c.403G>A | p.Glu135Lys | p.E135K | protein_coding | deleterious(0.01) | benign(0.17) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
SLC25A26 | SNV | Missense_Mutation | novel | c.269A>T | p.Lys90Ile | p.K90I | protein_coding | tolerated(0.13) | benign(0) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC25A26 | SNV | Missense_Mutation | novel | c.200N>C | p.Phe67Ser | p.F67S | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC25A26 | SNV | Missense_Mutation | novel | c.716N>T | p.Ala239Val | p.A239V | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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