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Gene: SLC22A23 |
Gene summary for SLC22A23 |
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Gene information | Species | Human | Gene symbol | SLC22A23 | Gene ID | 63027 |
Gene name | solute carrier family 22 member 23 | |
Gene Alias | C6orf85 | |
Cytomap | 6p25.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A1A5C7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63027 | SLC22A23 | P49T-E | Human | Esophagus | ESCC | 5.41e-08 | 6.48e-01 | 0.1768 |
63027 | SLC22A23 | P52T-E | Human | Esophagus | ESCC | 2.60e-05 | 3.31e-02 | 0.1555 |
63027 | SLC22A23 | P54T-E | Human | Esophagus | ESCC | 1.27e-08 | 1.33e-01 | 0.0975 |
63027 | SLC22A23 | P56T-E | Human | Esophagus | ESCC | 2.69e-02 | 3.58e-01 | 0.1613 |
63027 | SLC22A23 | P57T-E | Human | Esophagus | ESCC | 1.66e-13 | 5.60e-02 | 0.0926 |
63027 | SLC22A23 | P61T-E | Human | Esophagus | ESCC | 2.17e-07 | 7.03e-02 | 0.099 |
63027 | SLC22A23 | P62T-E | Human | Esophagus | ESCC | 1.71e-14 | 2.19e-01 | 0.1302 |
63027 | SLC22A23 | P65T-E | Human | Esophagus | ESCC | 2.00e-22 | 3.71e-01 | 0.0978 |
63027 | SLC22A23 | P74T-E | Human | Esophagus | ESCC | 9.78e-05 | 1.17e-02 | 0.1479 |
63027 | SLC22A23 | P75T-E | Human | Esophagus | ESCC | 5.89e-10 | 6.89e-04 | 0.1125 |
63027 | SLC22A23 | P76T-E | Human | Esophagus | ESCC | 2.73e-13 | 8.87e-03 | 0.1207 |
63027 | SLC22A23 | P79T-E | Human | Esophagus | ESCC | 1.59e-17 | 5.07e-02 | 0.1154 |
63027 | SLC22A23 | P80T-E | Human | Esophagus | ESCC | 3.53e-09 | 1.64e-01 | 0.155 |
63027 | SLC22A23 | P82T-E | Human | Esophagus | ESCC | 1.78e-06 | 2.03e-01 | 0.1072 |
63027 | SLC22A23 | P83T-E | Human | Esophagus | ESCC | 6.10e-14 | 2.88e-01 | 0.1738 |
63027 | SLC22A23 | P89T-E | Human | Esophagus | ESCC | 1.04e-05 | 3.41e-01 | 0.1752 |
63027 | SLC22A23 | P91T-E | Human | Esophagus | ESCC | 2.05e-06 | 7.40e-01 | 0.1828 |
63027 | SLC22A23 | P104T-E | Human | Esophagus | ESCC | 5.12e-03 | 3.73e-01 | 0.0931 |
63027 | SLC22A23 | P107T-E | Human | Esophagus | ESCC | 2.55e-07 | 7.31e-02 | 0.171 |
63027 | SLC22A23 | P127T-E | Human | Esophagus | ESCC | 2.55e-12 | 1.27e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC22A23 | SNV | Missense_Mutation | c.1091N>T | p.Pro364Leu | p.P364L | A1A5C7 | protein_coding | deleterious(0.04) | probably_damaging(0.984) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SLC22A23 | SNV | Missense_Mutation | rs757839112 | c.1102C>T | p.Arg368Trp | p.R368W | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC22A23 | SNV | Missense_Mutation | novel | c.823G>A | p.Ala275Thr | p.A275T | A1A5C7 | protein_coding | tolerated(0.11) | probably_damaging(0.994) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC22A23 | SNV | Missense_Mutation | rs781457847 | c.1649N>T | p.Ala550Val | p.A550V | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SLC22A23 | SNV | Missense_Mutation | c.1064N>C | p.Leu355Pro | p.L355P | A1A5C7 | protein_coding | deleterious(0) | possibly_damaging(0.802) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLC22A23 | SNV | Missense_Mutation | c.820N>A | p.Val274Met | p.V274M | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC22A23 | SNV | Missense_Mutation | rs778961106 | c.1327N>A | p.Gly443Arg | p.G443R | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC22A23 | SNV | Missense_Mutation | c.453N>G | p.Asn151Lys | p.N151K | A1A5C7 | protein_coding | tolerated(0.06) | benign(0.34) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC22A23 | deletion | Frame_Shift_Del | novel | c.1942delN | p.Glu648SerfsTer36 | p.E648Sfs*36 | A1A5C7 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC22A23 | SNV | Missense_Mutation | novel | c.1337N>T | p.His446Leu | p.H446L | A1A5C7 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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